Publications by authors named "Tiow Suan Sim"

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Oral streptococci subvert the host innate immune response through hydrogen peroxide.
Yi Ling Tang, Tiow Suan Sim, Kai Soo Tan

Sci Rep· January 2022

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Co-chaperones of Hsp90 in Plasmodium falciparum and their concerted roles in cellular regulation.
Chun-Song Chua, Huiyu Low, Tiow-Suan Sim

Parasitology· August 2014

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Plasmodium falciparum possesses a unique dual-specificity serine/threonine and tyrosine kinase, Pfnek3.
Huiyu Low, Chun Song Chua, Tiow-Suan Sim

Cell Mol Life Sci· May 2012

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Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90.
Stefan H Millson, Chun-Song Chua, S Mark Roe, Sigrun Polier, Svetlana Solovieva, Tiow-Suan Sim

FASEB J· November 2011

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Designing new β-lactams: implications from their targets, resistance factors and synthesizing enzymes.
Kian-Sim Goo, Tiow-Suan Sim

Curr Comput Aided Drug Des· March 2011

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Atypical caseinolytic protease homolog from Plasmodium falciparum possesses unusual substrate preference and a functional nuclear localization signal.
Wenjie Lin, Maurice Chan, Tiow-Suan Sim

Parasitol Res· November 2009

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Regulation of Plasmodium falciparum Pfnek3 relies on phosphorylation at its activation loop and at threonine 82.
Huiyu Low, Chun Song Chua, Tiow-Suan Sim

Cell Mol Life Sci· September 2009

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Directed evolution and rational approaches to improving Streptomyces clavuligerus deacetoxycephalosporin C synthase for cephalosporin production.
Kian-Sim Goo, Chun-Song Chua, Tiow-Suan Sim

J Ind Microbiol Biotechnol· May 2009

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Structural basis of the radicicol resistance displayed by a fungal hsp90.
Chrisostomos Prodromou, James M Nuttall, Stefan H Millson, S Mark Roe, Tiow-Suan Sim

ACS Chem Biol· April 2009

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A complete library of amino acid alterations at R306 in Streptomyces clavuligerus deacetoxycephalosporin C synthase demonstrates its structural role in the ring-expansion activity.
Kian Sim Goo, Chun Song Chua, Tiow-Suan Sim

Proteins· February 2008

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Relevant double mutations in bioengineered Streptomyces clavuligerus deacetoxycephalosporin C synthase result in higher binding specificities which improve penicillin bioconversion.
Kian Sim Goo, Chun Song Chua, Tiow-Suan Sim

Appl Environ Microbiol· February 2008

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Elucidation of active site residues of Arabidopsis thaliana flavonol synthase provides a molecular platform for engineering flavonols.
Chun Song Chua, Daniela Biermann, Kian Sim Goo, Tiow-Suan Sim

Phytochemistry· January 2008

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Pfnek3 functions as an atypical MAPKK in Plasmodium falciparum.
Huiyu Low, Yu Min Lye, Tiow-Suan Sim

Biochem Biophys Res Commun· September 2007

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Molecular basis for thermal properties of Streptomyces thermovulgaris fumarase C hinge at hydrophilic amino acids R163, E170 and S347.
Wenjie Lin, Maurice Chan, Liuh-Ling Goh, Tiow-Suan Sim

Appl Microbiol Biotechnol· May 2007

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Pfnek3: an atypical activator of a MAP kinase in Plasmodium falciparum.
Yu Min Lye, Maurice Chan, Tiow-Suan Sim

FEBS Lett· November 2006

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A relevant in vitro eukaryotic live-cell system for the evaluation of plasmodial protein localization.
Maurice Chan, Doreen S H Tan, Siew-Heng Wong, Tiow-Suan Sim

Biochimie· October 2006

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Characterization of amino acid variation at strategic positions in parasite and human proteases for selective inhibition of falcipains in Plasmodium falciparum.
Liuh Ling Goh, Tiow Suan Sim

Biochem Biophys Res Commun· September 2005

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Differences in biochemical properties of the Plasmodial falcipain-2 and berghepain-2 orthologues: implications for in vivo screens of inhibitors.
Cheryl Chan, Liuh Ling Goh, Tiow-Suan Sim

FEMS Microbiol Lett· August 2005

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Molecular cloning and functional characterization of fumarases C in Neisseria species.
Liuh Ling Goh, Timothy Barkham, Tiow Suan Sim

Antonie Van Leeuwenhoek· April 2005

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Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from Plasmodium falciparum.
Maurice Chan, Tiow-Suan Sim

Biochem Biophys Res Commun· January 2005

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Homology modeling and mutagenesis analyses of Plasmodium falciparum falcipain 2A: implications for rational drug design.
Liuh Ling Goh, Tiow Suan Sim

Biochem Biophys Res Commun· October 2004

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Soluble expression of a functionally active Plasmodium falciparum falcipain-2 fused to maltose-binding protein in Escherichia coli.
Liuh Ling Goh, Paxton Loke, Mulkit Singh, Tiow Suan Sim

Protein Expr Purif· December 2003

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Deacetoxycephalosporin C synthase isozymes exhibit diverse catalytic activity and substrate specificity.
Hong Soon Chin, Janet Sim, Keng Ing Seah, Tiow Suan Sim

FEMS Microbiol Lett· January 2003

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Molecular cloning and functional characterisation of VanX, a D-alanyl-D-alanine dipeptidase from Streptomyces coelicolor A3(2).
Ai Lin Tan, Paxton Loke, Tiow-Suan Sim

Res Microbiol· August 2002

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Malate synthase from Streptomyces clavuligerus NRRL3585: cloning, molecular characterization and its control by acetate.
Maurice Chan, Tiow-Suan Sim

Microbiology (Reading)· November 1998

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