Publications by authors named "Tip W Loo"

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A short cross-linker activates human P-glycoprotein missing a catalytic carboxylate.
Tip W Loo, David M Clarke

Biochem Pharmacol· December 2017

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Corrector VX-809 promotes interactions between cytoplasmic loop one and the first nucleotide-binding domain of CFTR.
Tip W Loo, David M Clarke

Biochem Pharmacol· July 2017

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Thiol-reactive drug substrates of human P-glycoprotein label the same sites to activate ATPase activity in membranes or dodecyl maltoside detergent micelles.
Tip W Loo, David M Clarke

Biochem Biophys Res Commun· July 2017

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Attachment of a 'molecular spring' restores drug-stimulated ATPase activity to P-glycoprotein lacking both Q loop glutamines.
Tip W Loo, David M Clarke

Biochem Biophys Res Commun· January 2017

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Drugs Modulate Interactions between the First Nucleotide-Binding Domain and the Fourth Cytoplasmic Loop of Human P-Glycoprotein.
Tip W Loo, David M Clarke

Biochemistry· May 2016

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P-glycoprotein ATPase activity requires lipids to activate a switch at the first transmission interface.
Tip W Loo, David M Clarke

Biochem Biophys Res Commun· April 2016

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Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein.
Tip W Loo, David M Clarke

J Biol Chem· December 2015

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The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein.
Tip W Loo, David M Clarke

J Biol Chem· July 2015

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Tariquidar inhibits P-glycoprotein drug efflux but activates ATPase activity by blocking transition to an open conformation.
Tip W Loo, David M Clarke

Biochem Pharmacol· December 2014

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Cysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity.
Tip W Loo, David M Clarke

J Biol Chem· September 2014

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The cystic fibrosis V232D mutation inhibits CFTR maturation by disrupting a hydrophobic pocket rather than formation of aberrant interhelical hydrogen bonds.
Tip W Loo, David M Clarke

Biochem Pharmacol· March 2014

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Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch.
Tip W Loo, David M Clarke

J Biol Chem· March 2014

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Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein.
Tip W Loo, David M Clarke

J Biol Chem· January 2014

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Drug rescue distinguishes between different structural models of human P-glycoprotein.
Tip W Loo, David M Clarke

Biochemistry· October 2013

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Corrector VX-809 stabilizes the first transmembrane domain of CFTR.
Tip W Loo, M Claire Bartlett, David M Clarke

Biochem Pharmacol· September 2013

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Bithiazole correctors rescue CFTR mutants by two different mechanisms.
Tip W Loo, M Claire Bartlett, David M Clarke

Biochemistry· August 2013

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Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface.
Tip W Loo, M Claire Bartlett, David M Clarke

J Biol Chem· July 2013

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A salt bridge in intracellular loop 2 is essential for folding of human p-glycoprotein.
Tip W Loo, David M Clarke

Biochemistry· May 2013

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Niemann-Pick NPC1: sterols to the rescue and beyond.
Tip W Loo, David M Clarke

Chem Biol· March 2013

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The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely together.
Tip W Loo, M Claire Bartlett, Michael R Detty, David M Clarke

J Biol Chem· August 2012

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Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1).
Alexandra Orchard, Gregory A Schamerhorn, Brandon D Calitree, Geri A Sawada, Tip W Loo

Bioorg Med Chem· July 2012

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Chalcogenopyrylium compounds as modulators of the ATP-binding cassette transporters P-glycoprotein (P-gp/ABCB1) and multidrug resistance protein 1 (MRP1/ABCC1).
Sean P Ebert, Bryan Wetzel, Robert L Myette, Gwenaëlle Conseil, Susan P C Cole, Tip W Loo

J Med Chem· May 2012

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Predicting P-glycoprotein-mediated drug transport based on support vector machine and three-dimensional crystal structure of P-glycoprotein.
Zsolt Bikadi, Istvan Hazai, David Malik, Katalin Jemnitz, Zsuzsa Veres, Tip W Loo

PLoS One· February 2012

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Corrector-mediated rescue of misprocessed CFTR mutants can be reduced by the P-glycoprotein drug pump.
Tip W Loo, M Claire Bartlett, Li Shi, David M Clarke

Biochem Pharmacol· February 2012

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Repair of CFTR folding defects with correctors that function as pharmacological chaperones.
Tip W Loo, David M Clarke

Methods Mol Biol· September 2011

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