Publications by authors named "Tobias Obser"

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Medulloblastoma in children with Fanconi anemia: Association with FA-D1/FA-N, SHH type and poor survival independent of treatment strategies.
Marthe Sönksen, Denise Obrecht-Sturm, Pablo Hernáiz Driever, Axel Sauerbrey, Norbert Graf, Tobias Obser

Neuro Oncol· November 2024

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The search for the underlying mutations causing VWD in 13 Venezuelan families.
Rita Marchi, Tobias Obser, Florian Oyen, Arlette Ruiz-Sáez, Apsara Boadas

Thromb Res· March 2024

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A conformational transition of the D'D3 domain primes von Willebrand factor for multimerization.
Sophia Gruber, Achim Löf, Adina Hausch, Fabian Kutzki, Res Jöhr, Tobias Obser

Blood Adv· September 2022

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Heparan sulfate dependent binding of plasmatic von Willebrand factor to blood circulating melanoma cells attenuates metastasis.
Yuanyuan Wang, Xiaobo Liu, Tobias Obser, Alexander T Bauer, Martin Heyes

Matrix Biol· August 2022

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Gain-of-Function Variant p.Pro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics.
Volker Huck, Po-Chia Chen, Emma-Ruoqi Xu, Alexander Tischer, Ulrike Klemm, Tobias Obser

Thromb Haemost· February 2022

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The activity of the intrinsically water-soluble enzyme ADAMTS13 correlates with the membrane state when bound to a phospholipid bilayer.
Andrej Kamenac, Tobias Obser, Achim Wixforth, Matthias F Schneider, Christoph Westerhausen

Sci Rep· December 2021

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Platelet adhesion and aggregate formation controlled by immobilised and soluble VWF.
Matthias F Schneider, Mohammad A Fallah, Christian Mess, Tobias Obser, Reinhard Schneppenheim

BMC Mol Cell Biol· September 2020

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Upshaw-Schulman syndrome-associated ADAMTS13 variants possess proteolytic activity at the surface of endothelial cells and in simulated circulation.
Anton Letzer, Katja Lehmann, Christian Mess, Gesa König, Tobias Obser

PLoS One· August 2020

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Evidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease.
Alexander Tischer, Maria A Brehm, Venkata R Machha, Laurie Moon-Tasson, Linda M Benson, Tobias Obser

J Mol Biol· January 2020

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Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor.
Achim Löf, Philipp U Walker, Steffen M Sedlak, Sophia Gruber, Tobias Obser

Proc Natl Acad Sci U S A· September 2019

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Alteration in GPIIb/IIIa Binding of VWD-Associated von Willebrand Factor Variants with C-Terminal Missense Mutations.
Gesa König, Tobias Obser, Olivier Marggraf, Sonja Schneppenheim, Ulrich Budde

Thromb Haemost· July 2019

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Characterization of VWF gene conversions causing von Willebrand disease.
Firdos Ahmad, Meganathan Kannan, Tobias Obser, Ulrich Budde, Sonja Schneppenheim

Br J Haematol· March 2019

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Von Willebrand Factor Mediates Pneumococcal Aggregation and Adhesion in Blood Flow.
Hilger Jagau, Ina-Kristin Behrens, Karen Lahme, Georgina Lorz, Reinhard W Köster, Tobias Obser

Front Microbiol· March 2019

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Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor.
Emma-Ruoqi Xu, Sören von Bülow, Po-Chia Chen, Peter J Lenting, Katra Kolšek, Tobias Obser

Blood· January 2019

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The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction.
Reinhard Schneppenheim, Natalie Hellermann, Maria A Brehm, Ulrike Klemm, Tobias Obser

Blood· January 2019

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Cellular stress induces erythrocyte assembly on intravascular von Willebrand factor strings and promotes microangiopathy.
Jan P Nicolay, Verena Thorn, Christoph Daniel, Kerstin Amann, Balasaheb Siraskar, Tobias Obser

Sci Rep· July 2018

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Genetic and Functional Characterization of ADAMTS13 Variants in a Patient Cohort with Upshaw-Schulman Syndrome Investigated in Germany.
Wolf Achim Hassenpflug, Tobias Obser, Julia Bode, Florian Oyen, Ulrich Budde

Thromb Haemost· April 2018

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Interaction of von Willebrand factor domains with collagen investigated by single molecule force spectroscopy.
Sandra Posch, Tobias Obser, Gesa König, Reinhard Schneppenheim, Robert Tampé

J Chem Phys· March 2018

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Space and Time Resolved Detection of Platelet Activation and von Willebrand Factor Conformational Changes in Deep Suspensions.
Jacopo Biasetti, Kaushik Sampath, Angel Cortez, Alaleh Azhir, Assaf A Gilad, Tobias Obser

Int J Biomed Imaging· November 2017

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Enhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping.
Alexander Tischer, Venkata R Machha, Juan P Frontroth, Maria A Brehm, Tobias Obser

J Mol Biol· July 2017

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Mutual A domain interactions in the force sensing protein von Willebrand factor.
Sandra Posch, Camilo Aponte-Santamaría, Richard Schwarzl, Andreas Karner, Matthias Radtke, Tobias Obser

J Struct Biol· January 2017

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Mutation G1629E Increases von Willebrand Factor Cleavage via a Cooperative Destabilization Mechanism.
Camilo Aponte-Santamaría, Svenja Lippok, Judith J Mittag, Tobias Obser, Reinhard Schneppenheim

Biophys J· January 2017

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Single molecule force spectroscopy data and BD- and MD simulations on the blood protein von Willebrand factor.
Sandra Posch, Camilo Aponte-Santamaría, Richard Schwarzl, Andreas Karner, Matthias Radtke, Tobias Obser

Data Brief· September 2016

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pH-Dependent Interactions in Dimers Govern the Mechanics and Structure of von Willebrand Factor.
Jochen P Müller, Achim Löf, Salomé Mielke, Tobias Obser, Linda K Bruetzel

Biophys J· July 2016

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Shear-Induced Unfolding and Enzymatic Cleavage of Full-Length VWF Multimers.
Svenja Lippok, Matthias Radtke, Tobias Obser, Lars Kleemeier, Reinhard Schneppenheim

Biophys J· February 2016

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