Publications by authors named "Todd Brusko"

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Human stem cell-derived β cells expressing an optimized CD155 reduce cytotoxic immune cell function for application in type 1 diabetes.
Matthew E Brown, Jessie M Barra, Marcus R Pina, James Proia, Todd M Brusko

Sci Adv· November 2025

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Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices.
Matthew W Becker, Matthew Brown, Katherine Wiseman, Ana Laura Chiodetti, Mollie K Huber, Todd M Brusko

bioRxiv· October 2025

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Protocol for processing and analyzing multiplexed images improves lymphatic cell identification and spatial architecture in human tissue.
Justin A Smith, Drew T Bloss, MacKenzie D Williams, Amanda L Posgai, Todd M Brusko, Maigan A Brusko

STAR Protoc· September 2025

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Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites.
Nora Lam, J Carlos Angel, Bruce A Buchholz, YoonSeung Lee, Stuart P Weisberg, Maigan Brusko, Todd M Brusko

Immunity· September 2025

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BayesCNet: Bayesian inference for cell type-specific regulatory networks leveraging cell type hierarchy in single-cell data.
Fengdi Zhao, Arkaprava Roy, Weijia Jin, Leeana Peters, Todd Brusko

bioRxiv· September 2025

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Challenges and Opportunities for Understanding the Pathogenesis of Type 1 Diabetes: An Endocrine Society Scientific Statement.
Aaron W Michels, Todd M Brusko, Carmella Evans-Molina, Dirk Homann, Sarah J Richardson

J Clin Endocrinol Metab· August 2025

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Autoimmune origin for immune checkpoint inhibitor-diabetes revealed by deep immune phenotyping of the pancreas.
Zoe Quandt, Arabella Young, Graham Larson Barlow, Jennifer A Smith, Irina Kusmartseva, Todd M Brusko

J Immunother Cancer· August 2025

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Human Stem Cell-Derived β-cells Expressing An Optimized CD155 Reduce Cytotoxic Immune Cell Function for Application in Type 1 Diabetes.
Matthew E Brown, Jessie M Barra, Marcus R Pina, James Proia, Todd M Brusko

bioRxiv· August 2025

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Epithelial-Mesenchymal Transition Activates YAP to Drive Malignant Progression and Immune Evasion.
Xi Huang, Mingyan Zhang, Alexander D Pearce, Matthew D Gibbons, Dan Jin, Todd M Brusko

Cancers (Basel)· August 2025

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TCR2HLA: calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes.
Koshlan Mayer-Blackwell, Anastasia Minervina, Mikhail Pogorelyy, Puneet Rawat, Melanie R Shapiro, Todd M Brusko

bioRxiv· July 2025

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Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset.
Gregory J Golden, Vincent H Wu, Jacob T Hamilton, Kevin R Amses, Melanie R Shapiro, Todd M Brusko

Nat Commun· May 2025

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Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes.
Miguel A Medina-Serpas, Maigan Brusko, Gregory J Golden, Martha Campbell-Thompson, Trevor Rogers, Todd M Brusko

bioRxiv· May 2025

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Characteristics of autoantibody-positive individuals without high-risk HLA-DR4-DQ8 or HLA-DR3-DQ2 haplotypes.
Maria J Redondo, David Cuthbertson, Andrea K Steck, Kevan C Herold, Richard Oram, Todd M Brusko

Diabetologia· March 2025

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Leveraging artificial intelligence and machine learning to accelerate discovery of disease-modifying therapies in type 1 diabetes.
Melanie R Shapiro, Erin M Tallon, Matthew E Brown, Amanda L Posgai, Mark A Clements, Todd M Brusko

Diabetologia· March 2025

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Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function.
Matthew E Brown, Puchong Thirawatananond, Leeana D Peters, Elizabeth J Kern, Sonali Vijay, Maigan A Brusko, Todd M Brusko

Diabetologia· February 2025

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Transcriptional control of T cell tissue adaptation and effector function in infants and adults.
Peter A Szabo, Hanna M Levitin, Thomas J Connors, David Chen, Jenny Jin, Maigan Brusko, Todd M Brusko

bioRxiv· February 2025

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The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium.
Stephanie J Hanna, Rachel H Bonami, Brian Corrie, Monica Westley, Amanda L Posgai, Todd M Brusko

Diabetologia· January 2025

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Characterizing cell-type spatial relationships across length scales in spatially resolved omics data.
Rafael Dos Santos Peixoto, Brendan F Miller, Maigan A Brusko, Gohta Aihara, Lyla Atta, Todd M Brusko

Nat Commun· January 2025

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Serological markers of exocrine pancreatic function are differentially informative for distinguishing individuals progressing to type 1 diabetes.
MacKenzie D Williams, Catherine Ramsey Grace, Amanda L Posgai, Kieran M McGrail, Maigan A Brusko, Todd M Brusko

BMJ Open Diabetes Res Care· January 2025

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Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illness.
Evan L Barrios, Leandro Balzano-Nogueira, Valerie E Polcz, Christine Rodhouse, Jack R Leary, Todd M Brusko, Maigan A Brusko

Front Immunol· December 2024

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Characterizing cell-type spatial relationships across length scales in spatially resolved omics data.
Rafael Dos Santos Peixoto, Brendan F Miller, Maigan A Brusko, Gohta Aihara, Lyla Atta, Todd M Brusko

bioRxiv· September 2024

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Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset.
Gregory J Golden, Vincent H Wu, Jacob T Hamilton, Kevin R Amses, Melanie R Shapiro, Todd M Brusko

bioRxiv· September 2024

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Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function.
Matthew E Brown, Puchong Thirawatananond, Leeana D Peters, Elizabeth J Kern, Sonali Vijay, Maigan A Brusko, Todd M Brusko

bioRxiv· July 2024

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Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span.
Joshua I Gray, Daniel P Caron, Steven B Wells, Rebecca Guyer, Peter Szabo, Maigan Brusko, Todd M Brusko

Sci Immunol· June 2024

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A global view of T cell metabolism in systemic lupus erythematosus.
Andrew Goetz, Joy Cagmat, Maigan Brusko, Todd M Brusko, Anna Rushin

Front Immunol· May 2024

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