Publications by authors named "Todd Butler"

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Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.
Martin Pettersson, Douglas S Johnson, John M Humphrey, Christopher W Am Ende, Todd W Butler

J Med Chem· June 2024

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Sulfur(VI) fluorides as tools in biomolecular and medicinal chemistry.
Sabrina N Carneiro, Samuel R Khasnavis, Jisun Lee, Todd W Butler, Jaimeen D Majmudar

Org Biomol Chem· February 2023

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Fluorophosphonates on-Demand: A General and Simplified Approach toward Fluorophosphonate Synthesis.
Jason K Dutra, Timothy L Foley, Zhen Huang, Ethan L Fisher, Erik A Lachapelle, Todd W Butler

Chembiochem· May 2021

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Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE.
Uthpala Seneviratne, Zhen Huang, Christopher W Am Ende, Todd W Butler, Leah Cleary

Cell Chem Biol· February 2021

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SuFEx Activation with Ca(NTf): A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides.
Subham Mahapatra, Cristian P Woroch, Todd W Butler, Sabrina N Carneiro, Sabrina C Kwan

Org Lett· June 2020

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Safety, Pharmacokinetics, and Pharmacodynamics of ME-401, an Oral, Potent, and Selective Inhibitor of Phosphatidylinositol 3-Kinase P110δ, Following Single Ascending Dose Administration to Healthy Volunteers.
Ofir Moreno, Todd Butler, Vanessa Zann, Ashley Willson, Pui Leung

Clin Ther· November 2018

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Introduction of a Crystalline, Shelf-Stable Reagent for the Synthesis of Sulfur(VI) Fluorides.
Hua Zhou, Paramita Mukherjee, Rongqiang Liu, Edelweiss Evrard, Dianpeng Wang, Todd W Butler

Org Lett· February 2018

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Identification and Profiling of a Selective and Brain Penetrant Radioligand for in Vivo Target Occupancy Measurement of Casein Kinase 1 (CK1) Inhibitors.
Travis T Wager, Paul Galatsis, Ramalakshmi Y Chandrasekaran, Todd W Butler, Jianke Li

ACS Chem Neurosci· September 2017

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Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.
Martin Pettersson, Douglas S Johnson, Danica A Rankic, Gregory W Kauffman, Christopher W Am Ende, Todd W Butler

Medchemcomm· April 2017

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Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.
Martin Pettersson, Douglas S Johnson, John M Humphrey, Todd W Butler, Christopher W Am Ende

ACS Med Chem Lett· May 2015

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Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior.
Travis T Wager, Ramalakshmi Y Chandrasekaran, Jenifer Bradley, David Rubitski, Helen Berke, Todd Butler

ACS Chem Neurosci· December 2014

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Ligand-protein interactions of selective casein kinase 1δ inhibitors.
Scot Mente, Eric Arnold, Todd Butler, Subramanyam Chakrapani, Ramalakshmi Chandrasekaran

J Med Chem· September 2013

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Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764).
Travis T Wager, Betty A Pettersen, Anne W Schmidt, Douglas K Spracklin, Scot Mente, Todd W Butler

J Med Chem· November 2011

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Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period.
Kevin M Walton, Katherine Fisher, David Rubitski, Michael Marconi, Qing-Jun Meng, Todd Butler

J Pharmacol Exp Ther· August 2009

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Metabolism, distribution and excretion of a selective N-methyl-D-aspartate receptor antagonist, traxoprodil, in rats and dogs.
Chandra Prakash, Donghui Cui, Michael J Potchoiba, Todd Butler

Drug Metab Dispos· August 2007

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Effect of once- or twice-daily MMX mesalamine (SPD476) for the induction of remission of mild to moderately active ulcerative colitis.
Gary R Lichtenstein, Michael A Kamm, Prabhakar Boddu, Natalya Gubergrits, Andrew Lyne, Todd Butler

Clin Gastroenterol Hepatol· January 2007

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Once-daily, high-concentration MMX mesalamine in active ulcerative colitis.
Michael A Kamm, William J Sandborn, Miguel Gassull, Stefan Schreiber, Lechoslaw Jackowski, Todd Butler

Gastroenterology· January 2007

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Plasma levels of B-lymphocyte stimulator increase with HIV disease progression.
Benigno Rodriguez, Hernan Valdez, William Freimuth, Todd Butler, Robert Asaad

AIDS· September 2003

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