Publications by authors named "Tom Skaria"

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Mechanistic insights into the cofactor binding dynamics and interaction between telmisartan and human thiopurine S-methyltransferase.
Archana Vakkayil, Deepthi Jose, Tom Skaria

J Pharm Sci· November 2025

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Novel Insights Into the Dynamic Conformational Transitions and Active Site Plasticity of Human Immunoregulatory Cathepsin S.
Durga Geetha, B A Aysha Hameeda, Deepthi Jose, Nishamol Kuriakose, Tom Skaria

Proteins· October 2025

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Cathepsin S: A key drug target and signalling hub in immune system diseases.
Durga Geetha, Tom Skaria

Int Immunopharmacol· May 2025

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Paracrine signaling mediators of vascular endothelial barrier dysfunction in sepsis: implications for therapeutic targeting.
Shahid Puthiyottil, Tom Skaria

Tissue Barriers· May 2025

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The developmental and inflammatory disease target protein ADAM17 is vulnerable to off-target interaction by the drug eltrombopag: Insights from molecular modeling.
Shahid Puthiyottil, Deepthi Jose, Nishamol Kuriakose, Tom Skaria

Comput Biol Med· March 2025

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Biomolecular interactions between the antibacterial ceftolozane and the human inflammatory disease target ADAM17: a drug repurposing study.
Ahsan Anjoom Sunil, Deepthi Jose, Sai Kumar Karri, Pukhraj Pukhraj, Jibin K Varughese, Tom Skaria

J Biomol Struct Dyn· November 2024

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Soluble vascular endothelial glycocalyx proteoglycans as potential therapeutic targets in inflammatory diseases.
Maneesha Kunnathattil, Pedapudi Rahul, Tom Skaria

Immunol Cell Biol· February 2024

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Improved method for surgical induction of chronic hypertension in mice.
Tom Skaria, Mostafa A Aboouf, Johannes Vogel

Biol Open· July 2022

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The Neuropeptide α-Calcitonin Gene-Related Peptide as the Mediator of Beneficial Effects of Exercise in the Cardiovascular System.
Tom Skaria, Johannes Vogel

Front Physiol· March 2022

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Novel regulators of airway epithelial barrier function during inflammation: potential targets for drug repurposing.
Ahsan Anjoom Sunil, Tom Skaria

Expert Opin Ther Targets· February 2022

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Transcriptional Regulation of Drug Metabolizing CYP Enzymes by Proinflammatory Wnt5A Signaling in Human Coronary Artery Endothelial Cells.
Tom Skaria, Esther Bachli, Gabriele Schoedon

Front Pharmacol· May 2021

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CGRP Receptor Antagonism in COVID-19: Potential Cardiopulmonary Adverse Effects.
Tom Skaria, Thomas Wälchli, Johannes Vogel

Trends Mol Med· January 2021

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Blood Pressure Normalization-Independent Cardioprotective Effects of Endogenous, Physical Activity-Induced αCGRP (α Calcitonin Gene-Related Peptide) in Chronically Hypertensive Mice.
Tom Skaria, Katharyn Jean Mitchell, Olga Vogel, Thomas Wälchli, Max Gassmann

Circ Res· December 2019

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Gene Ontology Analysis for Drug Targets of the Whole Genome Transcriptome of Human Vascular Endothelial Cells in Response to Proinflammatory IL-1.
Tom Skaria, Esther Bachli, Gabriele Schoedon

Front Pharmacol· April 2019

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RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1.
Tom Skaria, Esther Bachli, Gabriele Schoedon

Mol Med· August 2018

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Oxidative Phosphorylation System in Gastric Carcinomas and Gastritis.
René G Feichtinger, Daniel Neureiter, Tom Skaria, Silja Wessler, Timothy L Cover

Oxid Med Cell Longev· April 2018

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IL-4 Causes Hyperpermeability of Vascular Endothelial Cells through Wnt5A Signaling.
Tom Skaria, Julia Burgener, Esther Bachli, Gabriele Schoedon

PLoS One· July 2017

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Inflammatory Wnt5A signalling pathways affecting barrier function of human vascular endothelial cells.
Tom Skaria, Gabriele Schoedon

J Inflamm (Lond)· July 2017

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WIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells.
Tom Skaria, Esther Bachli, Gabriele Schoedon

J Inflamm (Lond)· May 2017

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Wnt5A/Ryk signaling critically affects barrier function in human vascular endothelial cells.
Tom Skaria, Esther Bachli, Gabriele Schoedon

Cell Adh Migr· January 2017

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