Publications by authors named "Tomas Leek"

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Rapid and flexible analytical characterization of oligonucleotides in early drug discovery.
Kathrin Stavenhagen, Manasses Jora, Carina Leandersson, Rebecca Rae, Julien Bourquin, Tomas Leek

J Chromatogr A· January 2026

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The complexities of oligonucleotide therapeutics: analytical challenges and opportunities within early drug discovery.
Manasses Jora, Christian Manz, Linda Thunberg, Mikko Hölttä, Tomas Leek

Bioanalysis· December 2025

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Towards automatically verifying chemical structures: the powerful combination of H NMR and IR spectroscopy.
J Benji Rowlands, Lina Jonsson, Jonathan M Goodman, Peter W A Howe, Werngard Czechtizky, Tomas Leek

Chem Sci· November 2025

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Correction to "Closing the Design-Make-Test-Analyze Loop: Interplay between Experiments and Predictions Drives PROTACs Bioavailability".
Zulma Santisteban Valencia, Jennifer Kingston, Filip Miljković, Hannah Rowbottom, Nadia Mann, Tomas Leek

J Med Chem· July 2025

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A comparative study of ion exchange vs. ion pair chromatography for preparative separation of oligonucleotides.
Martin Enmark, Cecilia Unoson, Marek Leśko, Olof Stålberg, Kathrin Stavenhagen, Tomas Leek

J Chromatogr A· April 2025

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Closing the Design-Make-Test-Analyze Loop: Interplay between Experiments and Predictions Drives PROTACs Bioavailability.
Zulma Santisteban Valencia, Jennifer Kingston, Filip Miljković, Hannah Rowbottom, Nadia Mann, Tomas Leek

J Med Chem· November 2024

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Unravelling the Link between Oligonucleotide Structure and Diastereomer Separation in Hydrophilic Interaction Chromatography.
Honorine Lardeux, Kathrin Stavenhagen, Clément Paris, Rikke Dueholm, Camille Kurek, Tomas Leek

Anal Chem· June 2024

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Strategies for predictive modeling of overloaded oligonucleotide elution profiles in ion-pair chromatography.
Marek Leśko, Krzysztof Kaczmarski, Manasses Jora, Kathrin Stavenhagen, Tomas Leek

J Chromatogr A· November 2023

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Analyzing proteolytic stability and metabolic hotspots of therapeutic peptides in two rodent pulmonary fluids.
Frank Wesche, Leonardo De Maria, Tomas Leek, Frank Narjes, James Bird

J Pharm Biomed Anal· February 2023

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Automated high-throughput in vitro assays to identify metabolic hotspots and protease stability of structurally diverse, pharmacologically active peptides for inhalation.
Frank Wesche, Leonardo De Maria, Tomas Leek, Frank Narjes, James Bird

J Pharm Biomed Anal· March 2022

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How well does molecular simulation reproduce environment-specific conformations of the intrinsically disordered peptides PLP, TP2 and ONEG?
Lauren M Reid, Ileana Guzzetti, Tor Svensson, Anna-Carin Carlsson, Wu Su, Tomas Leek

Chem Sci· February 2022

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First inter-laboratory study of a Supercritical Fluid Chromatography method for the determination of pharmaceutical impurities.
Amandine Dispas, Roland Marini, Vincent Desfontaine, Jean-Luc Veuthey, Dorina Kotoni, Tomas Leek

J Pharm Biomed Anal· November 2018

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Investigation of robustness for supercritical fluid chromatography separation of peptides: Isocratic vs gradient mode.
Martin Enmark, Emelie Glenne, Marek Leśko, Annika Langborg Weinmann, Tomas Leek

J Chromatogr A· September 2018

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The importance of ion-pairing in peptide purification by reversed-phase liquid chromatography.
Dennis Åsberg, Annika Langborg Weinmann, Tomas Leek, Richard J Lewis, Magnus Klarqvist

J Chromatogr A· May 2017

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Estimation of Nonlinear Adsorption Isotherms in Gradient Elution RP-LC of Peptides in the Presence of an Adsorbing Additive.
Dennis Åsberg, Marek Leśko, Tomas Leek, Jörgen Samuelsson, Krzysztof Kaczmarski

Chromatographia· March 2017

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Mucin-based stationary phases as tool for the characterization of drug-mucus interaction.
Andrea F G Gargano, Michael Lämmerhofer, Hans Lönn, Peter J Schoenmakers, Tomas Leek

J Chromatogr A· July 2014

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Mixed-mode chromatography with zwitterionic phosphopeptidomimetic selectors from Ugi multicomponent reaction.
Andrea F G Gargano, Tomas Leek, Wolfgang Lindner, Michael Lämmerhofer

J Chromatogr A· November 2013

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