Publications by authors named "Tomohiko Taguchi"

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Membrane-domain compartmentalization of active GPCRs by β-arrestins through PtdIns(4,5)P binding.
Ritsuki Kuramoto, Tatsuya Ikuta, Carlo Marion C Carino, Kouki Kawakami, Miisha Kushiro, Tomohiko Taguchi

Nat Chem Biol· December 2025

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Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism.
Akiko Ogawa, Satoshi Watanabe, Iuliia Ozerova, Allen Yi-Lun Tsai, Yoshihiko Kuchitsu, Tomohiko Taguchi

Cell· October 2025

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Reelin Increases the Sphingomyelin Content of the Plasma Membrane and Affects the Surface Expression of GPI-Anchored Proteins in Hippocampal Neurons.
Yuto Takekoshi, Hugo Ando, Takao Kohno, Hiroshi Takase, Tomohiko Taguchi

J Neurochem· September 2025

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Microautophagy: definition, classification, and the complexity of the underlying mechanisms.
Yasuyoshi Sakai, Christian Behrends, Ana Maria Cuervo, Jayanta Debnath, Masanori Izumi, Tomohiko Taguchi

Autophagy· September 2025

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Single-molecule imaging quantifies oncogenic KRAS dynamics for enhanced accuracy of therapeutic efficacy assessment.
Ryoma Yokoi, Toshiki Mori, Koichiro M Hirosawa, Ryojiro Kondo, Tomohiko Taguchi

iScience· September 2025

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Innate immune signals triggered on organelle membranes.
Yoshihiko Kuchitsu, Tomohiko Taguchi

J Biochem· July 2025

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Cell biological insights into human STING variants.
Shogo Koide, Eisuke Yumoto, Jun Nakayama, Shigeki Higashiyama, Yoshihiko Kuchitsu, Tomohiko Taguchi

Cell Struct Funct· June 2025

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A quantitative method to monitor STING degradation with dual-luciferase reporters.
Tsumugi Shoji, Kanako Sato, Ayumi Shinojima, Shogo Koide, Ruri Shindo, Tomohiko Taguchi

Cell Struct Funct· May 2025

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The common HAQ STING allele prevents clinical penetrance of COPA syndrome.
Noa Simchoni, Shogo Koide, Maryel Likhite, Yoshihiko Kuchitsu, Senkottuvelan Kadirvel, Tomohiko Taguchi

J Exp Med· April 2025

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Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic degradation of GPX4 by targeting mitochondria.
Yusuke Hirata, Yuto Yamada, Soma Taguchi, Ryota Kojima, Haruka Masumoto, Tomohiko Taguchi

Cell Death Dis· December 2024

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Lysosomal microautophagy: an emerging dimension in mammalian autophagy.
Yoshihiko Kuchitsu, Tomohiko Taguchi

Trends Cell Biol· July 2024

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A non-toxic equinatoxin-II reveals the dynamics and distribution of sphingomyelin in the cytosolic leaflet of the plasma membrane.
Toshiki Mori, Takahiro Niki, Yasunori Uchida, Kojiro Mukai, Yoshihiko Kuchitsu, Tomohiko Taguchi

Sci Rep· July 2024

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Collaboration between a cis-interacting natural killer cell receptor and membrane sphingolipid is critical for the phagocyte function.
Hitomi Karyu, Takahiro Niki, Yuriko Sorimachi, Shoji Hata, Shiho Shimabukuro-Demoto, Tomohiko Taguchi

Front Immunol· May 2024

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STINGing organelle surface with acid.
Yoshihiko Kuchitsu, Tomohiko Taguchi

EMBO Rep· April 2024

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Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol.
Haruka Kemmoku, Kanoko Takahashi, Kojiro Mukai, Toshiki Mori, Koichiro M Hirosawa, Tomohiko Taguchi

Nat Commun· January 2024

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Mentoring the next generation of cell biologists.
Derek A Applewhite, Needhi Bhalla, Nina Cabezas-Wallscheid, Neta Erez, Mengfeng Li, Tomohiko Taguchi

Nat Cell Biol· January 2024

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Membrane traffic governs the STING inflammatory signalling.
Tomohiko Taguchi

J Biochem· November 2023

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PPP1R12A is a recycling endosomal phosphatase that facilitates YAP activation.
Chiaki Inoue, Kojiro Mukai, Tatsuyuki Matsudaira, Jun Nakayama, Nozomu Kono, Tomohiko Taguchi

Sci Rep· November 2023

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TLR7/8 stress response drives histiocytosis in SLC29A3 disorders.
Takuma Shibata, Ryota Sato, Masato Taoka, Shin-Ichiroh Saitoh, Mayumi Komine, Tomohiko Taguchi

J Exp Med· September 2023

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FilGAP, a GAP for Rac1, down-regulates invadopodia formation in breast cancer cells.
Koji Saito, Sakino Ozawa, Yosuke Chiba, Ruri Takahashi, Ryoya Ogomori, Tomohiko Taguchi

Cell Struct Funct· September 2023

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Class B1 GPCR activation by an intracellular agonist.
Kazuhiro Kobayashi, Kouki Kawakami, Tsukasa Kusakizako, Atsuhiro Tomita, Michihiro Nishimura, Tomohiko Taguchi

Nature· June 2023

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STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes.
Yoshihiko Kuchitsu, Kojiro Mukai, Rei Uematsu, Yuki Takaada, Ayumi Shinojima, Tomohiko Taguchi

Nat Cell Biol· March 2023

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A non-nucleotide agonist that binds covalently to cysteine residues of STING.
Kentaro Matsumoto, Shenwei Ni, Hiroyuki Arai, Takashi Toyama, Yoshiro Saito, Tomohiko Taguchi

Cell Struct Funct· February 2023

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The activity of disease-causative STING variants can be suppressed by wild-type STING through heterocomplex formation.
Ruri Shindo, Yoshihiko Kuchitsu, Kojiro Mukai, Tomohiko Taguchi

Front Cell Dev Biol· November 2022

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Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation.
Masahiko Nishitani-Isa, Kojiro Mukai, Yoshitaka Honda, Hiroshi Nihira, Takayuki Tanaka, Tomohiko Taguchi

J Exp Med· June 2022

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