Publications by authors named "Torin Huzil"

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Novel Colchicine Derivatives and their Anti-cancer Activity.
Lorelei Johnson, Ing Swie Goping, Aja Rieger, Jonathan Y Mane, Torin Huzil

Curr Top Med Chem· August 2017

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Drug delivery through the skin: molecular simulations of barrier lipids to design more effective noninvasive dermal and transdermal delivery systems for small molecules, biologics, and cosmetics.
J Torin Huzil, Siv Sivaloganathan, Mohammad Kohandel, Marianna Foldvari

Wiley Interdiscip Rev Nanomed Nanobiotechnol· June 2015

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Preclinical development and ocular biodistribution of gemini-DNA nanoparticles after intravitreal and topical administration: towards non-invasive glaucoma gene therapy.
Samih Alqawlaq, Jeremy M Sivak, J Torin Huzil, Marina V Ivanova, John G Flanagan

Nanomedicine· November 2014

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A computational model for overcoming drug resistance using selective dual-inhibitors for aurora kinase A and its T217D variant.
Khaled H Barakat, J Torin Huzil, Kirk E Jordan, Constantinos Evangelinos, Michael Houghton

Mol Pharm· December 2013

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Effect of chemical permeation enhancers on stratum corneum barrier lipid organizational structure and interferon alpha permeability.
Shadi H Moghadam, Evi Saliaj, Shawn D Wettig, Chilbert Dong, Marina V Ivanova, J Torin Huzil

Mol Pharm· June 2013

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Pharmaceutical characterization of solid and dispersed carbon nanotubes as nanoexcipients.
Marina V Ivanova, Constanze Lamprecht, M Jimena Loureiro, J Torin Huzil, Marianna Foldvari

Int J Nanomedicine· September 2012

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Challenges in neuroprotective nanomedicine development: progress towards noninvasive gene therapy of glaucoma.
Samih Alqawlaq, J Torin Huzil, Marina V Ivanova, Marianna Foldvari

Nanomedicine (Lond)· July 2012

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Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping.
Melissa J Bennett, Khaled Barakat, J Torin Huzil, Jack Tuszynski, David C Schriemer

Chem Biol· July 2010

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Computational design and biological testing of highly cytotoxic colchicine ring A modifications.
John Torin Huzil, Philip Winter, Lorelei Johnson, Alexander L Weis, Tamas Bakos

Chem Biol Drug Des· June 2010

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Computer assisted design of second-generation colchicine derivatives.
J Torin Huzil, Jonathan Mane, Jack A Tuszynski

Interdiscip Sci· June 2010

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Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives.
Chih-Yuan Tseng, Jonathan Y Mane, Philip Winter, Lorelei Johnson, Torin Huzil

Mol Cancer· May 2010

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Characterization of an inhibitory dynamic pharmacophore for the ERCC1-XPA interaction using a combined molecular dynamics and virtual screening approach.
Khaled H Barakat, J Torin Huzil, Tyler Luchko, Lars Jordheim, Charles Dumontet

J Mol Graph Model· September 2009

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Identification and characterization of an intermediate taxol binding site within microtubule nanopores and a mechanism for tubulin isotype binding selectivity.
Holly Freedman, J Torin Huzil, Tyler Luchko, Richard F Ludueña, Jack A Tuszynski

J Chem Inf Model· February 2009

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Identification of tubulin drug binding sites and prediction of relative differences in binding affinities to tubulin isotypes using digital signal processing.
Ke Chen, J Torin Huzil, Holly Freedman, Parameswaran Ramachandran, Andreas Antoniou

J Mol Graph Model· November 2008

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Free energy calculations on the binding of colchicine and its derivatives with the alpha/beta-tubulin isoforms.
Jonathan Y Mane, Mariusz Klobukowski, J Torin Huzil, Jack Tuszynski

J Chem Inf Model· September 2008

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Microtubule assembly of isotypically purified tubulin and its mixtures.
Vahid Rezania, Olga Azarenko, Mary Ann Jordan, Hannes Bolterauer, Richard F Ludueña, J Torin Huzil

Biophys J· August 2008

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A unique mode of microtubule stabilization induced by peloruside A.
J Torin Huzil, John K Chik, Gordon W Slysz, Holly Freedman, Jack Tuszynski

J Mol Biol· May 2008

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Conformational analysis of the carboxy-terminal tails of human beta-tubulin isotypes.
Tyler Luchko, J Torin Huzil, Maria Stepanova, Jack Tuszynski

Biophys J· March 2008

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Direct catalysis of lysine 48-linked polyubiquitin chains by the ubiquitin-activating enzyme.
J Torin Huzil, Rajeet Pannu, Christopher Ptak, Grace Garen, Michael J Ellison

J Biol Chem· December 2007

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The roles of beta-tubulin mutations and isotype expression in acquired drug resistance.
J Torin Huzil, Ke Chen, Lukasz Kurgan, Jack A Tuszynski

Cancer Inform· April 2007

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Homology modeling of tubulin: influence predictions for microtubule's biophysical properties.
Eric J Carpenter, J Torin Huzil, Richard F Ludueña, Jack A Tuszynski

Eur Biophys J· December 2006

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Probabilistic analysis of the frequencies of amino acid pairs within characterized protein sequences.
Shiyi Shen, Bo Kai, Jishou Ruan, J Torin Huzil, Eric Carpenter

Physica A· October 2006

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Comparative modelling of human β tubulin isotypes and implications for drug binding.
J Torin Huzil, Richard F Ludueña, Jack Tuszynski

Nanotechnology· February 2006

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