Publications by authors named "Torsten Hechler"

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Site-Specific Modification of Native IgGs with Flexible Drug-Load.
Jöri E Wehrmüller, Julia C Frei, Torsten Hechler, Michael Kulke, Andreas Pahl

Chembiochem· April 2025

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Novel Amanitin-Based Antibody-Drug Conjugates Targeting TROP2 for the Treatment of Pancreatic Cancer.
Eleni Papacharisi, Alexandra C Braun, Marija Vranic, Andreas M Pahl, Torsten Hechler

Mol Cancer Ther· April 2025

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ETx-22, a Novel Nectin-4-Directed Antibody-Drug Conjugate, Demonstrates Safety and Potent Antitumor Activity in Low-Nectin-4-Expressing Tumors.
Marc Lopez, Emerence Crompot, Emmanuelle Josselin, Anne Farina, Marion Rubis, Torsten Hechler

Cancer Res Commun· November 2024

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AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53.
Zhiheng Zhang, Hongzhen Li, Yibin Deng, Kathleen Schuck, Susanne Raulefs, Torsten Hechler

Gastroenterology· November 2021

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Iodine-Mediated Tryptathionine Formation Facilitates the Synthesis of Amanitins.
Guiyang Yao, Caroline H Knittel, Simone Kosol, Marius T Wenz, Bettina G Keller, Torsten Hechler

J Am Chem Soc· September 2021

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Design, Synthesis, and Biochemical Evaluation of Alpha-Amanitin Derivatives Containing Analogs of the trans-Hydroxyproline Residue for Potential Use in Antibody-Drug Conjugates.
Kaveh Matinkhoo, Antonio A W L Wong, Chido M Hambira, Brandon Kato, Charlie Wei, Torsten Hechler

Chemistry· July 2021

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Enhancing the Pharmacokinetics and Antitumor Activity of an α-Amanitin-Based Small-Molecule Drug Conjugate via Conjugation with an Fc Domain.
Francesca Gallo, Barbara Korsak, Christoph Müller, Torsten Hechler, Desislava Yanakieva

J Med Chem· April 2021

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HDP-101, an Anti-BCMA Antibody-Drug Conjugate, Safely Delivers Amanitin to Induce Cell Death in Proliferating and Resting Multiple Myeloma Cells.
Vianihuini Figueroa-Vazquez, Jonathan Ko, Christian Breunig, Anja Baumann, Nicola Giesen, Torsten Hechler

Mol Cancer Ther· February 2021

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Targeted immunotherapy for HER2-low breast cancer with 17p loss.
Yujing Li, Yifan Sun, Michael Kulke, Torsten Hechler, Kevin Van der Jeught

Sci Transl Med· February 2021

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CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma.
Poornima Ramkumar, Anthony B Abarientos, Ruilin Tian, Meghan Seyler, Jaime T Leong, Torsten Hechler

Blood Adv· July 2020

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β-Glucuronidase triggers extracellular MMAE release from an integrin-targeted conjugate.
Paula López Rivas, Christoph Müller, Christian Breunig, Torsten Hechler, Andreas Pahl

Org Biomol Chem· May 2019

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Amanitins and their development as a payload for antibody-drug conjugates.
Andreas Pahl, Christian Lutz, Torsten Hechler

Drug Discov Today Technol· December 2018

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Synthesis and biological evaluation of RGD and isoDGR peptidomimetic-α-amanitin conjugates for tumor-targeting.
Lizeth Bodero, Paula López Rivas, Barbara Korsak, Torsten Hechler, Andreas Pahl

Beilstein J Org Chem· February 2018

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In Vitro Evolution of Bovine Foamy Virus Variants with Enhanced Cell-Free Virus Titers and Transmission.
Qiuying Bao, Michaela Hipp, Annette Hugo, Janet Lei, Yang Liu, Torsten Hechler

Viruses· November 2015

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Antibody-drug conjugate payloads.
Jan Anderl, Heinz Faulstich, Torsten Hechler, Michael Kulke

Methods Mol Biol· February 2014

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Feline foamy virus-based vectors: advantages of an authentic animal model.
Weibin Liu, Janet Lei, Yang Liu, Dragana Slavkovic Lukic, Ann-Mareen Räthe, Torsten Hechler

Viruses· July 2013

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Similar patterns of infection with bovine foamy virus in experimentally inoculated calves and sheep.
Magdalena Materniak, Torsten Hechler, Martin Löchelt, Jacek Kuzmak

J Virol· March 2013

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Complete genome sequences of two novel European clade bovine foamy viruses from Germany and Poland.
Torsten Hechler, Magdalena Materniak, Timo Kehl, Jacek Kuzmak, Martin Löchelt

J Virol· October 2012

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Pattern of seroreactivity against feline foamy virus proteins in domestic cats from Germany.
Anne Bleiholder, Michael Mühle, Torsten Hechler, Sarah Bevins, Sue vandeWoude

Vet Immunol Immunopathol· October 2011

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Restriction of feline retroviruses: lessons from cat APOBEC3 cytidine deaminases and TRIM5alpha proteins.
Carsten Münk, Torsten Hechler, Sarah Chareza, Martin Löchelt

Vet Immunol Immunopathol· March 2010

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Anaerobiosis inhibits gas vesicle formation in halophilic Archaea.
Torsten Hechler, Felicitas Pfeifer

Mol Microbiol· January 2009

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Glucose inhibits the formation of gas vesicles in Haloferax volcanii transformants.
Torsten Hechler, Miriam Frech, Felicitas Pfeifer

Environ Microbiol· January 2008

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A Rieske ferredoxin typifying a subtype within Rieske proteins: spectroscopic, biochemical and stability studies.
Arnulf Kletzin, Ana S Ferreira, Torsten Hechler, Tiago M Bandeiras, Miguel Teixeira

FEBS Lett· February 2005

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