Publications by authors named "Torsten Steinmetzer"

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TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells.
Dorothea Bestle, Miriam Ruth Heindl, Hannah Limburg, Thuy Van Lam van, Oliver Pilgram, Hong Moulton, David A Stein, Kornelia Hardes, Markus Eickmann, Olga Dolnik

Life Sci Alliance· September 2020

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Design, Synthesis, and Characterization of Dichlorobiphenyl-Derived Inhibitors of the Proprotein Convertase Furin.
Roman W Lange, Charlotte Boller, Michael Loresch, Konstantin Bloch, Eva Böttcher-Friebertshäuser, Torsten Steinmetzer

J Med Chem· December 2025

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Membrane disruption attenuates agonist potency in prostanoid receptors.
Uurtuya Hochban, Imke Wallenstein, Michaela Ulrich, Alwina Bittner, Lisa Spänig, Torsten Steinmetzer

Biochem J· October 2025

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Immunogenicity of NSDV GP38 and the role of furin in GP38 proteolytic processing.
Caroline Bost, Filipe Tomaz, Luna C Schmacke, Sven Reiche, Nabil G Seidah, Torsten Steinmetzer

J Virol· July 2025

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Repurposing of Furin Inhibitors to Reduce Pathogenic - and -Induced Cytotoxicity, Oxidative Stress and Inflammation in Mammalian Epithelial Cells.
Isabella Rumer, Lilla Tóth, Annelie Wohlert, András Adorján, Ákos Jerzsele, Torsten Steinmetzer

Antibiotics (Basel)· April 2025

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Macrocyclic Inhibitors Targeting the Prime Site of the Fibrinolytic Serine Protease Plasmin.
Simon J A Wiedemeyer, Guojie Wu, Heike Lang-Henkel, James C Whisstock, Ruby H P Law, Torsten Steinmetzer

ChemMedChem· December 2024

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Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells.
Marie Schwerdtner, Luna C Schmacke, Julia Nave, Hannah Limburg, Torsten Steinmetzer

Viruses· November 2024

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Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B-NS3 protease.
Simon Huber, Niklas J Braun, Luna C Schmacke, Robin Murra, Daniela Bender, Torsten Steinmetzer

Arch Pharm (Weinheim)· September 2024

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Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage.
Dorothea Bestle, Linda Bittel, Anke-Dorothee Werner, Lennart Kämper, Olga Dolnik, Torsten Steinmetzer

Virus Res· September 2024

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A molecular mechanism to diversify Ca signaling downstream of Gs protein-coupled receptors.
Julian Brands, Sergi Bravo, Lars Jürgenliemke, Lukas Grätz, Hannes Schihada, Torsten Steinmetzer

Nat Commun· September 2024

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In Vitro Evaluation of Antipseudomonal Activity and Safety Profile of Peptidomimetic Furin Inhibitors.
Sara Maluck, Rivka Bobrovsky, Miklós Poór, Roman W Lange, Torsten Steinmetzer

Biomedicines· September 2024

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PK/PD investigation of antiviral host matriptase/TMPRSS2 inhibitors in cell models.
Dávid Gamba, Nicholas van Eijk, Katalin Lányi, Katalin Monostory, Torsten Steinmetzer

Sci Rep· July 2024

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Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors.
Roman W Lange, Konstantin Bloch, Miriam Ruth Heindl, Jan Wollenhaupt, Manfred S Weiss, Torsten Steinmetzer

ChemMedChem· May 2024

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ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells.
Miriam Ruth Heindl, Anna-Lena Rupp, Marie Schwerdtner, Dorothea Bestle, Anne Harbig, Torsten Steinmetzer

J Virol· April 2024

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Antiviral Drug Candidate Repositioning for Infection in Non-Tumorigenic Cell Models.
Ashley Anzet van Niekerk, Sara Maluck, Patrik Mag, Csaba Kővágó, Ádám Kerek, Torsten Steinmetzer

Biomedicines· April 2024

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In vitro testing of host-targeting small molecule antiviral matriptase/TMPRSS2 inhibitors in 2D and 3D cell-based assays.
Nicholas van Eijk, Luna C Schmacke, Torsten Steinmetzer, Oliver Pilgram, Miklós Poór

Biomed Pharmacother· December 2023

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Thermodynamic characterization of a macrocyclic Zika virus NS2B/NS3 protease inhibitor and its acyclic analogs.
Stefan J Hammerschmidt, Simon Huber, Niklas J Braun, Marc Lander, Torsten Steinmetzer

Arch Pharm (Weinheim)· April 2023

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Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors.
Simon J A Wiedemeyer, Guojie Wu, T L Phuong Pham, Heike Lang-Henkel, Benjamin Perez Urzua, Torsten Steinmetzer

ChemMedChem· March 2023

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Boroleucine-Derived Covalent Inhibitors of the ZIKV Protease.
Niklas J Braun, Simon Huber, Luna C Schmacke, Andreas Heine, Torsten Steinmetzer

ChemMedChem· February 2023

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In Vitro Pharmacokinetic Behavior of Antiviral 3-Amidinophenylalanine Derivatives in Rat, Dog and Monkey Hepatocytes.
Katalin Lányi, Katalin Monostory, Torsten Steinmetzer, Ákos Jerzsele, Erzsébet Pászti-Gere

Biomedicines· February 2023

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Design, synthesis, and characterization of novel fluorogenic substrates of the proprotein convertases furin, PC1/3, PC2, PC5/6, and PC7.
Thuy Van Lam van, Teodora Ivanova, Iris Lindberg, Eva Böttcher-Friebertshäuser, Torsten Steinmetzer

Anal Biochem· October 2022

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Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors.
Oliver Pilgram, Aline Keils, Gerrit E Benary, Janis Müller, Stefan Merkl, Torsten Steinmetzer

Eur J Med Chem· August 2022

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In vitro characterization of the furin inhibitor MI-1851: Albumin binding, interaction with cytochrome P450 enzymes and cytotoxicity.
Erzsébet Pászti-Gere, Anna Szentkirályi-Tóth, Pál Szabó, Torsten Steinmetzer, Eszter Fliszár-Nyúl

Biomed Pharmacother· July 2022

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Transfer mechanism of cell-free synthesized membrane proteins into mammalian cells.
Simon Umbach, Roman Levin, Sebastian Neumann, Torsten Steinmetzer, Volker Dötsch

Front Bioeng Biotechnol· July 2022

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Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.
Simon Huber, Niklas J Braun, Luna C Schmacke, Jun Ping Quek, Robin Murra, Torsten Steinmetzer

J Med Chem· May 2022

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Interspecies Comparisons of the Effects of Potential Antiviral 3-Amidinophenylalanine Derivatives on Cytochrome P450 1A2 Isoenzyme.
Zsófia Fedor, Anna Szentkirályi-Tóth, Gábor Nagy, Zoltán Szimrók, Eszter Varga, Torsten Steinmetzer

Vet Sci· March 2022

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