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The overall discussions show strong agreement with the article, highlighting the essential roles of TMPRSS2 and furin in viral activation, with posts praising the research, discussing inhibition methods, and emphasizing potential treatments. The tone ranges from supportive acknowledgment to detailed insights into the virus's activation pathways, underscoring both scientific consensus and the perceived importance of the findings for future therapies.
Most posts clearly express strong support and acknowledgment of the importance of TMPRSS2 and furin in SARS-CoV-2 activation, reflecting consensus.
Posts demonstrate high engagement with the topic, discussing molecular mechanisms and potential therapeutic implications.
While many discuss the study's findings in detail, some are more confirmatory or supportive rather than deeply analytical.
The discussion emphasizes the significance of these proteases as therapeutic targets, indicating a recognition of high potential impact for COVID-19 treatment strategies.
Otro ejercicio visual. Os recuerdo que son artículos científicos. https://t.co/B7UOKpTOUe El hueco “añadido” aquí no alinea consensus RRxRR, saltándose el doble procesamiento proteolítico propio de coronavirus (RR,LL) Alinean consensus mínimo RxxR es que si no no encaja SC2.
Very nice article by Eva Böttcher-Friebertshäuser from Marburg on the two proteases required for SARS-CoV-2 activation https://t.co/fFkTOqtNn0
@MJnanostretch @Ayjchan @Rossana38510044 @EtaitLife @harishseshadri2 Polybasic clusters are easy to spot and they had already identified what they seemed to have thought was the nearby S2' cleavage site KPSKR https://t.co/4bbXrWntTI https://t.co/SQCvPlTZLW
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells https://t.co/wZ5CbGQmh8
SARS-CoV-2 replication strongly inhibited in Calu-3 cells in presence of furin inhibitor MI-1851 https://t.co/msFRrFq7n6
TMPRSS2とfurinは共にヒト気道細胞におけるSARS-CoV-2のタンパク質分解活性化に必須 TMPRSS2阻害剤とフーリン阻害剤との組み合わせは、ヒト気道細胞において高い抗ウイルス活性を示し、各阻害剤単独での治療と比較して低用量でのウイルス増殖の強力な減少を示した。 https://t.co/cSbF8Q05Kh
This video discusses how we learn about SARS-CoV-2 entry into human cells through its spike protein binding to the ACE2 receptor. It highlights the unique attributes of the virus and its implications for understanding…
This video explains the mechanisms of viral attachment and entry, particularly focusing on how SARS-CoV-2 enters human cells by binding to the ACE2 receptor. We explore the significance of the spike protein and its…
SARS-CoV-2 enters human airway cells by using host proteases, specifically furin and TMPRSS2, to activate its spike protein by cleaving it at two key sites. Inhibiting these proteases can block virus activation and…
Otro ejercicio visual. Os recuerdo que son artículos científicos. https://t.co/B7UOKpTOUe El hueco “añadido” aquí no alinea consensus RRxRR, saltándose el doble procesamiento proteolítico propio de coronavirus (RR,LL) Alinean consensus mínimo RxxR es que si no no encaja SC2.
@ikearobin @redheadlass1402 @HealeyErika https://t.co/bQJMMIRxvJ
@MJnanostretch @Ayjchan @Rossana38510044 @EtaitLife @harishseshadri2 Polybasic clusters are easy to spot and they had already identified what they seemed to have thought was the nearby S2' cleavage site KPSKR https://t.co/4bbXrWntTI https://t.co/SQCvPlTZLW
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells https://t.co/YBmFTjjX55
RT @ClaasPotthoff: SARS-CoV-2 replication strongly inhibited in Calu-3 cells in presence of furin inhibitor MI-1851 https://t.co/msFRrFq7n6
RT @ClaasPotthoff: SARS-CoV-2 replication strongly inhibited in Calu-3 cells in presence of furin inhibitor MI-1851 https://t.co/msFRrFq7n6
RT @ClaasPotthoff: SARS-CoV-2 replication strongly inhibited in Calu-3 cells in presence of furin inhibitor MI-1851 https://t.co/msFRrFq7n6
SARS-CoV-2 replication strongly inhibited in Calu-3 cells in presence of furin inhibitor MI-1851 https://t.co/msFRrFq7n6
RT @ckpfaller: Great work! Congrats @evafrieb TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway…
RT @jonmoulton: TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells. https://t.co/WrZjQMZMc…
14.2/x https://t.co/NpZ0Edx4Lj https://t.co/51dAurHdfv
@maja4185 Und die Anwesenheit von TMPRSS2, einer Protease, die in der Zellmembran sitzt, scheint die Verschmelzung des Spikeproteins mit der Zelle durch Spaltung des Spikes an einer anderen Stelle (S2') auch noch effizienter zu gestalten: https://t.co/oTfsTM2XFb
https://t.co/iJgUQLqj2S
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells https://t.co/JEywGz7gtx
Also this source as general understanding: https://t.co/BuBxqyIDWr
@florian_krammer @BenBCDE @NateSilver538 @DouthatNYT @sailorrooscout whether the polybasic cleavage site is retained or gradually lost from viral spike clearly depends on MOI, the composition of the host proteases and which entry pathway is used by the respective cell line (compare Vero, 293T, Calu3, Caco2…). https://t.co/rKoFVcmVwK
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells https://t.co/6ySOYVgCcD https://t.co/0er0BjkDTy https://t.co/MVRbjT1NZK
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells https://t.co/6ySOYVgCcD https://t.co/0er0BjkDTy https://t.co/LWYEKcN7NH
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells https://t.co/6ySOYVgCcD https://t.co/0er0BjkDTy
RT @Friedemann1: Very nice article by Eva Böttcher-Friebertshäuser from Marburg on the two proteases required for SARS-CoV-2 activation ht…
Very nice article by Eva Böttcher-Friebertshäuser from Marburg on the two proteases required for SARS-CoV-2 activation https://t.co/fFkTOqtNn0
Sars Human from the bottom up https://t.co/672cnZf5c7
@Krolli5 This is was done and dusted back in May in a really good piece of research from Germany, then preprint now published. Here is the published papers via @TheSeeker268 https://t.co/ZcvLqI6vuM
RT @Alzhacker: TMPRSS2とfurinは共にヒト気道細胞におけるSARS-CoV-2のタンパク質分解活性化に必須 TMPRSS2阻害剤とフーリン阻害剤との組み合わせは、ヒト気道細胞において高い抗ウイルス活性を示し、各阻害剤単独での治療と比較して低用量でのウイ…
RT @TheSeeker268: TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells https://t.co/wZ5CbGQ…
RT @Alzhacker: TMPRSS2とfurinは共にヒト気道細胞におけるSARS-CoV-2のタンパク質分解活性化に必須 TMPRSS2阻害剤とフーリン阻害剤との組み合わせは、ヒト気道細胞において高い抗ウイルス活性を示し、各阻害剤単独での治療と比較して低用量でのウイ…
RT @Alzhacker: TMPRSS2とfurinは共にヒト気道細胞におけるSARS-CoV-2のタンパク質分解活性化に必須 TMPRSS2阻害剤とフーリン阻害剤との組み合わせは、ヒト気道細胞において高い抗ウイルス活性を示し、各阻害剤単独での治療と比較して低用量でのウイ…
RT @Alzhacker: TMPRSS2とfurinは共にヒト気道細胞におけるSARS-CoV-2のタンパク質分解活性化に必須 TMPRSS2阻害剤とフーリン阻害剤との組み合わせは、ヒト気道細胞において高い抗ウイルス活性を示し、各阻害剤単独での治療と比較して低用量でのウイ…
TMPRSS2とfurinは共にヒト気道細胞におけるSARS-CoV-2のタンパク質分解活性化に必須 TMPRSS2阻害剤とフーリン阻害剤との組み合わせは、ヒト気道細胞において高い抗ウイルス活性を示し、各阻害剤単独での治療と比較して低用量でのウイルス増殖の強力な減少を示した。 https://t.co/cSbF8Q05Kh
RT @TheSeeker268: TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells https://t.co/wZ5CbGQ…
RT @TheSeeker268: TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells https://t.co/wZ5CbGQ…
@monarchdiaries @__ice9 @Valueinvestor41 @gstanchev @halvorz @liljurist @lewistlc @pathdoc3 @88549439 @csentropy @AndyBiotech @julienpotet @Crashcart @Hongma123 @YinPD @assur153 @macroliter @VirusWhisperer Another paper published 23 July Not about cell-cell fusion. Using Calu-3 cell. "Inhibition of either TMPRSS2 or furin activity suppresses multicycle replication of SARS-CoV-2 in human airway epithelial cells" https://t.co/7JnpGWIbwK Cathepsin was not so important in this setup https://t.co/R9rQvKwVik
RT @TheSeeker268: TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells https://t.co/wZ5CbGQ…
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells https://t.co/wZ5CbGQmh8
Great work! Congrats @evafrieb TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells https://t.co/by1eGF2LGl
RT @jonmoulton: TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells. https://t.co/WrZjQMZMc…
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells. https://t.co/WrZjQMZMcY #Morpholino
TMPRSS2 & furin proteases activate #SARS-CoV-2 spike protein S. Inhibition of either protease blocks S protein mediated virus entry > promising approach for #COVID-19 treatment. @Uni_MR @SBeckerLab https://t.co/SH2DZkf756 https://t.co/RbAoayfuzX