Publications by authors named "Travis B Lear"

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NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β-TrCP1/FBXO5 Axis.
Yao Tong, Travis B Lear, Ferhan Tuncer, John J Villandre, Áine N Boudreau

Adv Sci (Weinh)· September 2025

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Inhibition of virally induced TFEB proteasomal degradation as a host-centric therapeutic approach for coronaviral infection.
Travis B Lear, Mads B Larsen, Bo Lin, Benjamin R Treat, Qing Cao

Sci Adv· June 2025

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E3 ubiquitin ligase ZBTB25 suppresses beta coronavirus infection through ubiquitination of the main viral protease MPro.
Travis B Lear, Áine N Boudreau, Karina C Lockwood, Elise Chu, Daniel P Camarco

J Biol Chem· December 2023

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KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation.
Karina C Lockwood, Travis B Lear, Shristi Rajbhandari, Alison C McKelvey, Sarah R Dunn

FEBS J· August 2023

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Senolytic vaccination: a new mandate for cardiovascular health?
Travis B Lear, Toren Finkel

J Cardiovasc Aging· April 2022

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A Repurposed Drug Screen for Compounds Regulating Aquaporin 5 Stability in Lung Epithelial Cells.
John Villandre, Virginia White, Travis B Lear, Yanwen Chen, Ferhan Tuncer

Front Pharmacol· January 2022

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A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry.
Yanwen Chen, Travis B Lear, John W Evankovich, Mads B Larsen, Bo Lin

Nat Commun· June 2021

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A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance.
Yuan Liu, Michael J Jurczak, Travis B Lear, Bo Lin, Mads B Larsen

Nat Chem Biol· March 2021

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A high throughput screen for TMPRSS2 expression identifies FDA-approved and clinically advanced compounds that can limit SARS-CoV-2 entry.
Yanwen Chen, Travis B Lear, John W Evankovich, Mads B Larsen, Bo Lin

Res Sq· August 2020

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Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1.
Yuan Liu, Travis B Lear, Manish Verma, Kent Zq Wang, P Anthony Otero

JCI Insight· June 2020

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A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis.
Yanwen Chen, John W Evankovich, Travis B Lear, Ferhan Tuncer, Jason R Kennerdell

Redox Biol· May 2020

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Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis.
Travis B Lear, Karina C Lockwood, Mads Larsen, Ferhan Tuncer, Jason R Kennerdell

J Biol Chem· March 2020

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The RNFT2/IL-3Rα axis regulates IL-3 signaling and innate immunity.
Yao Tong, Travis B Lear, John Evankovich, Yanwen Chen, James D Londino

JCI Insight· February 2020

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The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing.
Travis B Lear, Karina C Lockwood, Yurong Ouyang, John W Evankovich, Mads B Larsen

J Biol Chem· November 2019

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KIAA0317 regulates pulmonary inflammation through SOCS2 degradation.
Travis B Lear, Alison C McKelvey, John W Evankovich, Shristi Rajbhandari, Tiffany A Coon

JCI Insight· October 2019

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Post-translational modification of the interferon-gamma receptor alters its stability and signaling.
James D Londino, Dexter L Gulick, Travis B Lear, Tomeka L Suber, Nathaniel M Weathington

Biochem J· October 2017

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RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity.
Alison C McKelvey, Travis B Lear, Sarah R Dunn, John Evankovich, James D Londino

Elife· November 2016

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Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase.
SeungHye Han, Travis B Lear, Jacob A Jerome, Shristi Rajbhandari, Courtney A Snavely

J Biol Chem· July 2015

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