Publications by authors named "Tricia Protack"

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The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.
Alicia Regueiro-Ren, Sing-Yuen Sit, Yan Chen, Jie Chen, Jacob J Swidorski, Tricia Protack

J Med Chem· September 2022

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GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile.
Ira Dicker, Jerry L Jeffrey, Tricia Protack, Zeyu Lin, Mark Cockett

Antimicrob Agents Chemother· January 2022

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Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.
Jacob J Swidorski, Susan Jenkins, Umesh Hanumegowda, Dawn D Parker, Brett R Beno, Tricia Protack

Bioorg Med Chem Lett· March 2021

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Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors.
Manoj Patel, B Narasimhulu Naidu, Ira Dicker, Helen Higley, Zeyu Lin, Tricia Protack

Bioorg Med Chem· July 2020

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Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.
Guo Li, Nicholas A Meanwell, Mark R Krystal, David R Langley, B Narasimhulu Naidu, Tricia Protack

J Med Chem· March 2020

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Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.
Kevin M Peese, B Narasimhulu Naidu, Manoj Patel, Chen Li, David R Langley, Tricia Protack

Bioorg Med Chem Lett· February 2020

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Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176).
Alicia Regueiro-Ren, Jacob J Swidorski, Zheng Liu, Yan Chen, Ny Sin, Tricia Protack

J Med Chem· August 2018

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The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.
Yan Chen, Sing-Yuen Sit, Jie Chen, Jacob J Swidorski, Zheng Liu, Tricia Protack

Bioorg Med Chem Lett· May 2018

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The Second-Generation Maturation Inhibitor GSK3532795 Maintains Potent Activity Toward HIV Protease Inhibitor-Resistant Clinical Isolates.
Neelanjana Ray, Tianbo Li, Zeyu Lin, Tricia Protack, Petronella Maria van Ham

J Acquir Immune Defic Syndr· May 2017

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Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors.
Zeyu Lin, Joseph Cantone, Hao Lu, Beata Nowicka-Sans, Tricia Protack

PLoS Pathog· November 2016

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Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.
Beata Nowicka-Sans, Tricia Protack, Zeyu Lin, Zhufang Li, Sharon Zhang

Antimicrob Agents Chemother· July 2016

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Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.
Alicia Regueiro-Ren, Zheng Liu, Yan Chen, Ny Sin, Sing-Yuen Sit, Tricia Protack

ACS Med Chem Lett· June 2016

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C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.
Zheng Liu, Jacob J Swidorski, Beata Nowicka-Sans, Brian Terry, Tricia Protack

Bioorg Med Chem· April 2016

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Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.
Jacob J Swidorski, Zheng Liu, Sing-Yuen Sit, Jie Chen, Yan Chen, Tricia Protack

Bioorg Med Chem Lett· April 2016

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In vitro cross-resistance profile of nucleoside reverse transcriptase inhibitor (NRTI) BMS-986001 against known NRTI resistance mutations.
Zhufang Li, Brian Terry, William Olds, Tricia Protack, Carol Deminie

Antimicrob Agents Chemother· November 2013

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CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells.
Fraser J Sim, Crystal R McClain, Steven J Schanz, Tricia L Protack, Martha S Windrem

Nat Biotechnol· September 2011

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Mammalian enabled (Mena) is a critical regulator of cardiac function.
Frédérick Aguilar, Stephen L Belmonte, Rashmi Ram, Sami F Noujaim, Olga Dunaevsky, Tricia L Protack

Am J Physiol Heart Circ Physiol· May 2011

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Identification of Nogo as a novel indicator of heart failure.
Tara A Bullard, Tricia L Protack, Frédérick Aguilar, Suveer Bagwe, H Todd Massey

Physiol Genomics· January 2008

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