Publications by authors named "Trinayan Kashyap"

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SINE compounds activate exportin 1 degradation through an allosteric mechanism.
Casey E Wing, Ho Yee Joyce Fung, Bert Kwanten, Tolga Cagatay, Ashley B Niesman, Trinayan Kashyap

Nat Chem Biol· December 2025

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SINE compounds activate exportin-1 degradation via an allosteric mechanism.
Casey Elizabeth Wing, Ho Yee Joyce Fung, Bert Kwanten, Tolga Cagatay, Ashley B Niesman, Trinayan Kashyap

bioRxiv· June 2025

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Focusing on Selinexor for Holding and Bridging Prior to CAR-T in Relapsed/Refractory Multiple Myeloma.
Jack Khouri, Douglas Sborov, Adriana Rossi, Thomas Martin, Trinayan Kashyap

J Clin Med· June 2025

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Modulation of anti-tumour immunity by XPO1 inhibitors.
Jack G Fisher, Laura G Bartlett, Trinayan Kashyap, Christopher J Walker, Salim I Khakoo

Explor Target Antitumor Ther· April 2025

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HAPLN1 confers multiple myeloma cell resistance to several classes of therapeutic drugs.
Mailee Huynh, Hae Yeun Chang, Dominique N Lisiero, Irene M Ong, Trinayan Kashyap

PLoS One· December 2022

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Small Molecule Inhibitors of Nuclear Export and the Amelioration of Lupus by Modulation of Plasma Cell Generation and Survival.
Javier Rangel-Moreno, Maria de la Luz Garcia-Hernandez, Teresa Owen, Jennifer Barnard, Enrique Becerril-Villanueva, Trinayan Kashyap

Arthritis Rheumatol· August 2022

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Selinexor inhibits growth of patient derived chordomas as a single agent and in combination with abemaciclib through diverse mechanisms.
Christopher J Walker, Hua Chang, Leah Henegar, Trinayan Kashyap, Sharon Shacham

Front Oncol· August 2022

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A Case Report of a 58-Year-Old Woman with a Diagnosis of High-Risk Myeloma Refractory to Multiple Line of Therapy and Treated with Selinexor, Bortezomib, and Dexamethasone Prior to Allogeneic Stem Cell Transplantation.
Michael Cass, Andrew B McDonald, Osnat Ben-Shahar, Yosef Landesman, Trinayan Kashyap

Am J Case Rep· April 2022

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Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo.
Trinayan Kashyap, Jackelyn Murray, Christopher J Walker, Hua Chang, Sharon Tamir

Antiviral Res· August 2021

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Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells.
Md Hafiz Uddin, Yiwei Li, Husain Yar Khan, Irfana Muqbil, Amro Aboukameel, Trinayan Kashyap

Int J Mol Sci· June 2021

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Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma.
John A DeSisto, Patrick Flannery, Rakeb Lemma, Amrita Pathak, Shelby Mestnik, Trinayan Kashyap

Mol Cancer Ther· February 2020

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Venetoclax response is enhanced by selective inhibitor of nuclear export compounds in hematologic malignancies.
Melissa A Fischer, Sharon Y Friedlander, Maria P Arrate, Hua Chang, Agnieszka E Gorska, Trinayan Kashyap

Blood Adv· February 2020

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Down-regulation of AR splice variants through XPO1 suppression contributes to the inhibition of prostate cancer progression.
Amro Aboukameel, Irfana Muqbil, Erkan Baloglu, William Senapedis, Yosef Landesman, Trinayan Kashyap

Oncotarget· October 2018

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Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents.
Trinayan Kashyap, Christian Argueta, Thaddeus Unger, Boris Klebanov, Sophia Debler

Oncotarget· July 2018

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Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas.
Natalia Saenz-Ponce, Rachael Pillay, Lilia Merida de Long, Trinayan Kashyap, Christian Argueta

Sci Transl Med· June 2018

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Selinexor synergizes with dexamethasone to repress mTORC1 signaling and induce multiple myeloma cell death.
Christian Argueta, Trinayan Kashyap, Boris Klebanov, Thaddeus J Unger, Cathy Guo

Oncotarget· May 2018

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Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis.
Kellie R Machlus, Stephen K Wu, Prakrith Vijey, Thomas S Soussou, Zhi-Jian Liu, Trinayan Kashyap

Blood· August 2017

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Selective Inhibitors of Nuclear Export (SINE) compounds block proliferation and migration of triple negative breast cancer cells by restoring expression of ARRDC3.
Young Hwa Soung, Trinayan Kashyap, Thalia Nguyen, Garima Yadav, Hua Chang

Oncotarget· August 2017

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A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia.
Ramiro Garzon, Michael Savona, Rachid Baz, Michael Andreeff, Nashat Gabrail, Trinayan Kashyap

Blood· June 2017

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Clinical Dosing Regimen of Selinexor Maintains Normal Immune Homeostasis and T-cell Effector Function in Mice: Implications for Combination with Immunotherapy.
Paul M Tyler, Mariah M Servos, Romy C de Vries, Boris Klebanov, Trinayan Kashyap

Mol Cancer Ther· March 2017

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The Exportin-1 Inhibitor Selinexor Exerts Superior Antitumor Activity when Combined with T-Cell Checkpoint Inhibitors.
Matthew R Farren, Rebecca C Hennessey, Reena Shakya, Omar Elnaggar, Gregory Young, Trinayan Kashyap

Mol Cancer Ther· March 2017

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XPO1 Inhibition using Selinexor Synergizes with Chemotherapy in Acute Myeloid Leukemia by Targeting DNA Repair and Restoring Topoisomerase IIα to the Nucleus.
Parvathi Ranganathan, Trinayan Kashyap, Xueyan Yu, Xiaomei Meng, Tzung-Huei Lai

Clin Cancer Res· December 2016

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Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death.
Trinayan Kashyap, Christian Argueta, Amro Aboukameel, Thaddeus John Unger, Boris Klebanov

Oncotarget· November 2016

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XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myeloma.
Joel G Turner, Trinayan Kashyap, Jana L Dawson, Juan Gomez, Alexis A Bauer

Oncotarget· November 2016

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Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds.
Marsha Crochiere, Trinayan Kashyap, Ori Kalid, Sharon Shechter, Boris Klebanov

BMC Cancer· November 2015

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