Publications by authors named "Tuna Mutis"

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A T-cell-based metric of immune age predicts outcomes in older patients with myeloma receiving daratumumab-based therapy.
Wassilis S C Bruins, Febe Smits, Carolien Duetz, Kaz Groen, Charlotte L B M Korst, Tuna Mutis

Blood· November 2025

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Emerging strategies in CAR-T cell therapy for acute myeloid leukemia: overcoming heterogeneity and improving safety through dual-antigen targeting.
Ángeles Ocaña-Cara, Tuna Mutis, Jort J van der Schans

Exp Hematol Oncol· November 2025

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Cytoskeletal dynamics and mitochondrial rearrangements drive cell fate upon antibody-induced complement activation in DLBCL.
Hilma J van der Horst, Tamás Csikós, Marjolein Quik, Jort J van der Schans, Klaas de Lint, Tuna Mutis

Blood Cancer J· October 2025

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Immune signatures in older patients with newly diagnosed multiple myeloma are associated with survival outcomes of first-line therapy irrespective of frailty levels.
Wassilis S C Bruins, Febe Smits, Carolien Duetz, Kazem Nasserinejad, Kazimierz Groen, Tuna Mutis

Hemasphere· October 2025

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Surface downmodulation of TIM3 safeguards healthy cells but not acute myeloid leukemia from CAR T-cell therapy.
Jort J van der Schans, Paresh Vishwasrao, Renée Poels, Morgan Antti, Ziyu Wang, Tuna Mutis

Hemasphere· July 2025

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The bone marrow NK-cell profile predicts MRD negativity in patients with multiple myeloma treated with daratumumab-based therapy.
Charlotte L B M Korst, Sabrin Tahri, Carolien Duetz, Wassilis S C Bruins, A Vera de Jonge, Tuna Mutis

Blood· June 2025

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Lymphoma-on-chip model reveals that lymph node stromal cells promote diffuse large B-cell lymphoma survival and migration.
Mohammad Jouybar, Aleksandra M Mikula, Nanouk Zuidmeer, Tanja Konijn, A Vera de Jonge, Tuna Mutis

Mater Today Bio· April 2025

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A convenient viral transduction based method for advanced multi-engineering of primary human (CAR) T-cells.
Jort J van der Schans, Afroditi Katsarou, George Kladis, Citlali Bar, Max Medina Ramirez, Tuna Mutis

J Genet Eng Biotechnol· December 2024

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Response to DA-EPOCH-R is associated with activation of 'fitter' cytotoxic T cells in patients with newly diagnosed double and triple hit high-grade B-cell lymphoma.
A Vera De Jonge, Wassilis S C Bruins, Carolien Duetz, Charlotte L B M Korst, Rosa Rentenaar, Tuna Mutis

Haematologica· November 2024

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Enhancing Fc-mediated effector functions of monoclonal antibodies: The example of HexaBodies.
Hilma J van der Horst, Tuna Mutis

Immunol Rev· November 2024

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Preclinical evaluation of the CD38-targeting engineered toxin body MT-0169 against multiple myeloma.
Wassilis S C Bruins, Rosa Rentenaar, John Newcomb, Wenrou Zheng, Ruud W J Ruiter, Tuna Mutis

Hemasphere· November 2024

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Delineating MYC-Mediated Escape Mechanisms from Conventional and T Cell-Redirecting Therapeutic Antibodies.
Anna Vera de Jonge, Tamás Csikós, Merve Eken, Elianne P Bulthuis, Pino J Poddighe, Tuna Mutis

Int J Mol Sci· November 2024

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T-Cell Characteristics Impact Response and Resistance to T-Cell-Redirecting Bispecific Antibodies in Multiple Myeloma.
Christie P M Verkleij, Chloe A O'Neill, Marloes E C Broekmans, Kristine A Frerichs, Wassilis S C Bruins, Tuna Mutis

Clin Cancer Res· July 2024

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Preclinical activity of allogeneic SLAMF7-specific CAR T-cells (UCARTCS1) in multiple myeloma.
Charlotte L B M Korst, Chloe O'Neill, Wassilis S C Bruins, Meliha Cosovic, Inoka Twickler, Tuna Mutis

J Immunother Cancer· July 2024

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Distinct peripheral T-cell and NK-cell profiles in HGBL-MYC/BCL2 vs patients with DLBCL NOS.
A Vera de Jonge, Carolien Duetz, Wassilis S C Bruins, Charlotte L B M Korst, Rosa Rentenaar, Tuna Mutis

Blood Adv· March 2024

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Specific Targeting of Multiple Myeloma by Dual Split-signaling Chimeric Antigen Receptor T cells Directed against CD38 and CD138.
Jort J van der Schans, Ziyu Wang, Jennemiek van Arkel, Thijs van Schaik, Afroditi Katsarou, Tuna Mutis

Clin Cancer Res· October 2023

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Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity.
Ida H Hiemstra, Kim C M Santegoets, Maarten L Janmaat, Bart E C G De Goeij, Wessel Ten Hagen, Tuna Mutis

EBioMedicine· July 2023

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NK Cell Phenotype Is Associated With Response and Resistance to Daratumumab in Relapsed/Refractory Multiple Myeloma.
Christie P M Verkleij, Kristine A Frerichs, Marloes E C Broekmans, Carolien Duetz, Chloe A O'Neill, Tuna Mutis

Hemasphere· May 2023

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Efficacy and safety of daratumumab combined with all-trans retinoic acid in relapsed/refractory multiple myeloma.
Kristine A Frerichs, Monique C Minnema, Mark-David Levin, Annemiek Broijl, Gerard M J Bos, Tuna Mutis

Blood Adv· December 2021

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Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence.
Afroditi Katsarou, Maria Sjöstrand, Jyoti Naik, Jorge Mansilla-Soto, Dionysia Kefala, Tuna Mutis

Sci Transl Med· December 2021

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Current State of the Art and Prospects of T Cell-Redirecting Bispecific Antibodies in Multiple Myeloma.
Mashhour Hosny, Christie P M Verkleij, Jort van der Schans, Kristine A Frerichs, Tuna Mutis

J Clin Med· October 2021

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CD38-specific Chimeric Antigen Receptor Expressing Natural Killer KHYG-1 Cells: A Proof of Concept for an "Off the Shelf" Therapy for Multiple Myeloma.
Arwen Stikvoort, Jort van der Schans, Subhashis Sarkar, Renée Poels, Ruud Ruiter, Tuna Mutis

Hemasphere· July 2021

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Bone Marrow Mesenchymal Stromal Cell-mediated Resistance in Multiple Myeloma Against NK Cells can be Overcome by Introduction of CD38-CAR or TRAIL-variant.
Lisa C Holthof, Arwen Stikvoort, Hilma J van der Horst, Anne T Gelderloos, Renée Poels, Tuna Mutis

Hemasphere· May 2021

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Efficacy and Safety of Durvalumab Combined with Daratumumab in Daratumumab-Refractory Multiple Myeloma Patients.
Kristine A Frerichs, Christie P M Verkleij, Meletios A Dimopoulos, Jhon A Marin Soto, Sonja Zweegman, Tuna Mutis

Cancers (Basel)· May 2021

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