Publications by authors named "Tuomas Knowles"

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A Mathematical Model of Cellular Aggregation Predicts Patterns of Tau Accumulation in Neurodegenerative Disease.
Shih-Huan Huang, Annelies Quaegebeur, Tanrada Pansuwan, Timothy Rittman, Ruiyan Wang, Tuomas Pj Knowles

Adv Sci (Weinh)· January 2026

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The Liquid State of RIM1α and RBP Condensates is Maintained by Lipids.
Charlotte M Fischer, Zenon Toprakcioglu, Ella de Csilléry, Gabriele S Kaminski Schierle, Tuomas P J Knowles

ACS Nano· December 2025

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PhaseXplorer Creates High-Dimensional Phase Diagrams with Closed-Loop Active Learning.
Stef A H Jansen, Lasse S A Dreyer, Jule van Basten, Yihan Yao, Daniel E Otzen, Tuomas P J Knowles

ACS Nano· November 2025

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Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity.
Samuel J Resnick, Seema Qamar, Pushya Krishna, Vladislav Korobeynikov, Hannes Ausserwoger, Tuomas P J Knowles

Nat Commun· November 2025

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Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal.
Matthew W Cotton, Shriram Venkatesan, Joseph S Beckwith, Dorothea Böken, Catherine K Xu, Tuomas P J Knowles

bioRxiv· October 2025

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Optofluidic Waveguides for the Label-Free Study of Silk Protein Aggregates.
Jan R Heck, Zenon Toprakcioglu, Tobias E Naegele, Michael H Frosz, Tuomas P J Knowles

ACS Omega· October 2025

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Direct Observation of the Conformational Transitions in Tau and Their Correlation with Phase Behavior.
Jitao Wen, Yiming Tang, Tomas Sneideris, Hannes Ausserwöger, Liu Hong, Tuomas P J Knowles

JACS Au· September 2025

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Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates.
Alyssa Miller, Zenon Toprakcioglu, Seema Qamar, Peter St George-Hyslop, Francesco Simone Ruggeri, Tuomas P J Knowles

Commun Chem· September 2025

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On-Chip De Novo Production of mRNA Vaccine in Lipid Nanoparticles.
Shai Zilberzwige-Tal, Aviad Levin, Assaf Ezra, Uri Elia, Gal Finkelstein-Zuta, Tuomas Pj Knowles

Small· August 2025

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Diffusing protein binders to intrinsically disordered proteins.
Caixuan Liu, Kejia Wu, Hojun Choi, Hannah L Han, Xueli Zhang, Tuomas P J Knowles

Nature· August 2025

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A Charge-Driven Strategy for Covalent Modification and Modulation of Biomolecular Condensates.
Zhewei Chen, Lu Liu, Jerome Cattin, Tuomas P J Knowles, Gonçalo J L Bernardes

J Am Chem Soc· August 2025

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Quantifying collective interactions in biomolecular phase separation.
Hannes Ausserwöger, Ella de Csilléry, Daoyuan Qian, Georg Krainer, Timothy J Welsh, Tuomas P J Knowles

Nat Commun· August 2025

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Current practices in the study of biomolecular condensates: a community comment.
Simon Alberti, Paolo Arosio, Robert B Best, Steven Boeynaems, Danfeng Cai, Tuomas P J Knowles

Nat Commun· August 2025

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Global kinetic model of lipid-induced -synuclein aggregation and its inhibition by small molecules.
Alisdair Stevenson, Roxine Staats, Alexander J Dear, David Voderholzer, Jesper E Dreier, Tuomas P J Knowles

Proc Natl Acad Sci U S A· July 2025

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Kinetics of seeded protein aggregation: Theory and application.
Alexander J Dear, Georg Meisl, Jing Hu, Tuomas P J Knowles, Sara Linse

J Chem Phys· July 2025

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Using a stable protein scaffold to display peptides that bind to alpha-synuclein fibrils.
Samuel Bismut, Matthias M Schneider, Masashi Miyasaki, Yuqing Feng, Ellis J Wilde, Tuomas P J Knowles

Protein Sci· June 2025

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Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates.
Tin Long Chris Ng, Mateo P Hoare, M Julia Maristany, Ellis J Wilde, Tomas Sneideris, Tuomas P J Knowles

Chem Sci· June 2025

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Microfluidics for protein interaction studies: current methods, challenges, and future perspectives.
Matthias M Schneider, Tuomas P J Knowles, Sandro Keller, Georg Krainer

Eur Biophys J· June 2025

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A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro.
Natasha S Lewis, Silja Zedlitz, Hannes Ausserwöger, Patrick M McCall, Lars Hubatsch, Tuomas P J Knowles

Proc Natl Acad Sci U S A· May 2025

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High-throughput Screening of the Mechanical Properties of Peptide Assemblies.
Sarah K Yorke, Zhenze Yang, Aviad Levin, Alice Ray, Jeremy Owusu Boamah, Tuomas P J Knowles

ArXiv· May 2025

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Phosphorylation enables allosteric control of a viral condensate.
Julia Acker, Xinyu Wang, Daniel Desirò, Tanushree Agarwal, Alice Colyer, Tuomas P J Knowles

bioRxiv· May 2025

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Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates.
Nadia A Erkamp, Mina Farag, Yuanxin Qiu, Daoyuan Qian, Tomas Sneideris, Tuomas P J Knowles

Nat Commun· April 2025

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Aggregation of α-synuclein splice isoforms through a phase separation pathway.
Alexander Röntgen, Zenon Toprakcioglu, Samuel T Dada, Owen M Morris, Tuomas P J Knowles

Sci Adv· April 2025

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A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner.
Sourav Dasadhikari, Shamasree Ghosh, Sudip Pal, Tuomas P J Knowles, Kanchan Garai

Commun Chem· April 2025

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Learning the rules of peptide self-assembly through data mining with large language models.
Zhenze Yang, Sarah K Yorke, Tuomas P J Knowles, Markus J Buehler

Sci Adv· March 2025

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