Publications by authors named "Tuomas P Knowles"

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A Mathematical Model of Cellular Aggregation Predicts Patterns of Tau Accumulation in Neurodegenerative Disease.
Shih-Huan Huang, Annelies Quaegebeur, Tanrada Pansuwan, Timothy Rittman, Ruiyan Wang, Tuomas Pj Knowles

Adv Sci (Weinh)· October 2025

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On-Chip De Novo Production of mRNA Vaccine in Lipid Nanoparticles.
Shai Zilberzwige-Tal, Aviad Levin, Assaf Ezra, Uri Elia, Gal Finkelstein-Zuta, Tuomas Pj Knowles

Small· August 2025

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Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma.
Matthias M Schneider, Marc Emmenegger, Catherine K Xu, Itzel Condado Morales, Georg Meisl, Tuomas Pj Knowles

Life Sci Alliance· February 2022

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Liquid-liquid phase separation underpins the formation of replication factories in rotaviruses.
Florian Geiger, Julia Acker, Guido Papa, Xinyu Wang, William E Arter, Tuomas Pj Knowles

EMBO J· November 2021

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The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.
Georg Meisl, Tuomas Pj Knowles, David Klenerman

Curr Opin Neurobiol· April 2020

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Physical principles of filamentous protein self-assembly kinetics.
Thomas C T Michaels, Lucie X Liu, Georg Meisl, Tuomas P J Knowles

J Phys Condens Matter· April 2017

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Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers.
Patrick Varilly, Adam P Willard, Julius B Kirkegaard, Tuomas P J Knowles, David Chandler

J Chem Phys· April 2017

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Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.
Francesco A Aprile, Paolo Arosio, Giuliana Fusco, Serene W Chen, Janet R Kumita, Tuomas P J Knowles

Biochemistry· March 2017

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A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.
Michele Perni, Céline Galvagnion, Alexander Maltsev, Georg Meisl, Martin B D Müller, Tuomas P J Knowles

Proc Natl Acad Sci U S A· February 2017

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Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease.
Johnny Habchi, Sean Chia, Ryan Limbocker, Benedetta Mannini, Minkoo Ahn, Tuomas P J Knowles

Proc Natl Acad Sci U S A· January 2017

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Microfluidic devices fabricated using fast wafer-scale LED-lithography patterning.
Pavan K Challa, Tadas Kartanas, Jérôme Charmet, Tuomas P J Knowles

Biomicrofluidics· January 2017

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β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.
James W P Brown, Alexander K Buell, Thomas C T Michaels, Georg Meisl, Jacqueline Carozza, Tuomas P J Knowles

Sci Rep· November 2016

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Dynamics of heteromolecular filament formation.
Alexander J Dear, Thomas C T Michaels, Tuomas P J Knowles

J Chem Phys· November 2016

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Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces.
Yang Song, Ulyana Shimanovich, Thomas C T Michaels, Qingming Ma, Jingmei Li, Tuomas P J Knowles

Nat Commun· October 2016

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Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation.
Yingbo Zhang, Alexander K Buell, Thomas Müller, Erwin De Genst, Justin Benesch, Tuomas P J Knowles

Chembiochem· October 2016

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Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.
Patrick Flagmeier, Georg Meisl, Michele Vendruscolo, Tuomas P J Knowles, Christopher M Dobson

Proc Natl Acad Sci U S A· September 2016

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Amyloid Fibrils as Building Blocks for Natural and Artificial Functional Materials.
Tuomas P J Knowles, Raffaele Mezzenga

Adv Mater· August 2016

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Controlling the Physical Dimensions of Peptide Nanotubes by Supramolecular Polymer Coassembly.
Lihi Adler-Abramovich, Pini Marco, Zohar A Arnon, Rhiannon C G Creasey, Thomas C T Michaels, Tuomas P J Knowles

ACS Nano· August 2016

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Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform.
Thomas O Mason, Thomas C T Michaels, Aviad Levin, Ehud Gazit, Christopher M Dobson, Tuomas P J Knowles

J Am Chem Soc· August 2016

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Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation.
Paolo Arosio, Tommy Cedervall, Tuomas P J Knowles, Sara Linse

Anal Biochem· July 2016

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Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms.
Marija Iljina, Gonzalo A Garcia, Alexander J Dear, Jennie Flint, Priyanka Narayan, Tuomas P J Knowles

Sci Rep· June 2016

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Fluctuations in the Kinetics of Linear Protein Self-Assembly.
Thomas C T Michaels, Alexander J Dear, Julius B Kirkegaard, Kadi L Saar, David A Weitz, Tuomas P J Knowles

Phys Rev Lett· June 2016

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Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism.
Chi L L Pham, Anthony Rey, Victor Lo, Margaux Soulès, Qin Ren, Tuomas P J Knowles

Sci Rep· May 2016

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A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions.
Therese W Herling, David J O'Connell, Mikael C Bauer, Jonas Persson, Ulrich Weininger, Tuomas P J Knowles

Biophys J· May 2016

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Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones.
Jonathan D Taylor, William J Hawthorne, Joanne Lo, Alexander Dear, Neha Jain, Tuomas P J Knowles

Sci Rep· April 2016

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