Publications by authors named "Tushar D Bhagat"

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Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: a phase 1b/2 clinical trial and correlative analyses.
Courtney D DiNardo, Divij Verma, Natalia Baran, Tushar D Bhagat, Anna Skwarska

Nat Cancer· October 2024

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Study of efficacy and longevity of immune response to third and fourth doses of COVID-19 vaccines in patients with cancer: A single arm clinical trial.
Astha Thakkar, Kith Pradhan, Benjamin Duva, Juan Manuel Carreno, Srabani Sahu, Tushar D Bhagat

Elife· March 2023

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PU.1-Dependent Enhancer Inhibition Separates Tet2-Deficient Hematopoiesis from Malignant Transformation.
Maria M Aivalioti, Boris A Bartholdy, Kith Pradhan, Tushar D Bhagat, Aliona Zintiridou

Blood Cancer Discov· September 2022

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Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations.
Gaurav S Choudhary, Andrea Pellagatti, Bogos Agianian, Molly A Smith, Tushar D Bhagat

Elife· August 2022

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Correction: Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer.
Yang Zhang, Xiaoyi Chen, Huamin Wang, Shanisha Gordon-Mitchell, Srabani Sahu, Tushar D Bhagat

J Hematol Oncol· July 2022

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Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer.
Yang Zhang, Xiaoyi Chen, Huamin Wang, Shanisha Gordon-Mitchell, Srabani Sahu, Tushar D Bhagat

J Hematol Oncol· May 2022

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High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster.
Sakshi Jasra, Orsi Giricz, Rachel Zeig-Owens, Kith Pradhan, David G Goldfarb, Tushar D Bhagat

Nat Med· March 2022

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Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer.
Lauren C Shapiro, Astha Thakkar, Sean T Campbell, Stefanie K Forest, Kith Pradhan, Tushar D Bhagat

Cancer Cell· January 2022

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ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine.
Nora E Rahmani, Nandini Ramachandra, Srabani Sahu, Nadege Gitego, Andrea Lopez, Tushar D Bhagat

Blood Cancer J· September 2021

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First-in-human study of inhaled Azacitidine in patients with advanced non-small cell lung cancer.
Haiying Cheng, Yiyu Zou, Chirag D Shah, Ni Fan, Tushar D Bhagat

Lung Cancer· April 2021

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Biological basis for efficacy of activin receptor ligand traps in myelodysplastic syndromes.
Amit Verma, Rajasekhar Nvs Suragani, Srinivas Aluri, Nishi Shah, Tushar D Bhagat

J Clin Invest· February 2020

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Misidentification of and other mutations in cancer due to highly homologous genomic regions.
Timothy G Bowler, Kith Pradhan, Yu Kong, Matthias Bartenstein, Kerry A Morrone, Tushar D Bhagat

Leuk Lymphoma· December 2019

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Phase II Study of the ALK5 Inhibitor Galunisertib in Very Low-, Low-, and Intermediate-Risk Myelodysplastic Syndromes.
Valeria Santini, David Valcárcel, Uwe Platzbecker, Rami S Komrokji, Ann L Cleverly, Tushar D Bhagat

Clin Cancer Res· December 2019

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Stem cell mutations can be detected in myeloma patients years before onset of secondary leukemias.
Ashwin Sridharan, Carolina D Schinke, George Georgiev, Mariana Da Silva Ferreira, Victor Thiruthuvanathan, Tushar D Bhagat, Chirag K Bhagat

Blood Adv· December 2019

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Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts.
Tushar D Bhagat, Dagny Von Ahrens, Meelad Dawlaty, Yiyu Zou, Joelle Baddour, Prafulla Bhagat

Elife· November 2019

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Loss of Function of DOCK4 in Myelodysplastic Syndromes Stem Cells is Restored by Inhibitors of DOCK4 Signaling Networks.
Sriram Sundaravel, Wen-Liang Kuo, Jong Jin Jeong, Gaurav S Choudhary, Shanisha Gordon-Mitchell, Tushar D Bhagat

Clin Cancer Res· September 2019

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Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis.
Jong Jin Jeong, Xiaorong Gu, Ji Nie, Sriram Sundaravel, Hui Liu, Tushar D Bhagat

Cancer Discov· June 2019

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U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies.
Molly A Smith, Gaurav S Choudhary, Andrea Pellagatti, Kwangmin Choi, Lyndsey C Bolanos, Tushar D Bhagat

Nat Cell Biol· May 2019

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Ascorbic acid-induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma.
Niraj Shenoy, Tushar D Bhagat, John Cheville, Christine Lohse, Sanchari Bhattacharyya

J Clin Invest· March 2019

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Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells.
Aditi Shastri, Gaurav Choudhary, Margarida Teixeira, Shanisha Gordon-Mitchell, Nandini Ramachandra, Tushar D Bhagat

J Clin Invest· December 2018

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North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies.
Urvi A Shah, Elaine Y Chung, Orsi Giricz, Kith Pradhan, Keisuke Kataoka, Tushar D Bhagat, Chirag Bhagat

Blood· October 2018

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The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma.
Orsi Giricz, Yongkai Mo, Kimberly B Dahlman, Xiomaris M Cotto-Rios, Chiara Vardabasso, Tushar D Bhagat

JCI Insight· July 2018

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Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways.
Sanchari Bhattacharyya, Kith Pradhan, Nathaniel Campbell, Jozef Mazdo, Aparna Vasantkumar, Tushar D Bhagat

Genome Res· November 2017

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Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation.
Tushar D Bhagat, Si Chen, Matthias Bartenstein, A Trevor Barlowe, Dagny Von Ahrens, Prafullla Bhagat

Cancer Res· September 2017

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The role of stromal cancer-associated fibroblasts in pancreatic cancer.
Dagny von Ahrens, Tushar D Bhagat, Deepak Nagrath, Anirban Maitra, Amit Verma

J Hematol Oncol· March 2017

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