Publications by authors named "Tyler A Johnson"

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Form and function of actin impacts actin health and aging.
Maxim Averbukh, Hunter Nelson, Tiffany Wang, Caitlin M Lange, Athena Alcala, Tyler A Johnson

bioRxiv· November 2025

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Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging.
Naibedya Dutta, Joe A Gerke, Sofia F Odron, Joseph D Morris, Adam Hruby, Tyler A Johnson

Geroscience· December 2024

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Further Probing the Properties of a Unique Sponge-derived Alkaloid Through the Isolation of a New (-)-(5)-(8)-(14)-Mycothiazole Analogue.
Joe A Gerke, Sofia F Odron, Juri Kim, Naibedya Dutta, Jacqueline G Clarke, Tyler A Johnson

J Nat Prod· October 2024

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Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging.
Naibedya Dutta, Joe A Gerke, Sofia F Odron, Joseph D Morris, Adam Hruby, Tyler A Johnson

bioRxiv· November 2023

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In Vivo Evaluation of (-)-Zampanolide Demonstrates Potent and Persistent Antitumor Efficacy When Targeted to the Tumor Site.
Leila Takahashi-Ruiz, Joseph D Morris, Phillip Crews, Tyler A Johnson, April L Risinger

Molecules· July 2022

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Re-evaluation of the Fijianolide/Laulimalide Chemotype Suggests an Alternate Mechanism of Action for C-15/C-20 Analogs.
Joseph D Morris, Leila Takahashi-Ruiz, Lauren N Persi, Jonathan C Summers, Erin P McCauley, Tyler A Johnson

ACS Omega· March 2022

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Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8 Configuration.
Tyler A Johnson, Joseph D Morris, David A Coppage, Colon V Cook, Lauren N Persi

ACS Med Chem Lett· February 2020

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The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.
James B McAlpine, Shao-Nong Chen, Andrei Kutateladze, John B MacMillan, Giovanni Appendino, Tyler A Johnson

Nat Prod Rep· January 2019

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Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.
James B McAlpine, Shao-Nong Chen, Andrei Kutateladze, John B MacMillan, Giovanni Appendino, Tyler A Johnson

Nat Prod Rep· January 2019

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The potential of achiral sponge-derived and synthetic bromoindoles as selective cytotoxins against PANC-1 tumor cells.
Nicholas Lorig-Roach, Frances Hamkins-Indik, Tyler A Johnson, Karen Tenney, Frederick A Valeriote

Tetrahedron· January 2018

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Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the Endorphins.
Tyler A Johnson, Laura Milan-Lobo, Tao Che, Madeline Ferwerda, Eptisam Lambu

ACS Chem Neurosci· March 2017

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Another Look at Pyrroloiminoquinone Alkaloids-Perspectives on Their Therapeutic Potential from Known Structures and Semisynthetic Analogues.
Sheng Lin, Erin P McCauley, Nicholas Lorig-Roach, Karen Tenney, Cassandra N Naphen, Tyler A Johnson

Mar Drugs· March 2017

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Biosynthetic products from a nearshore-derived gram-negative bacterium enable reassessment of the kailuin depsipeptides.
Christine M Theodore, Nicholas Lorig-Roach, Patrick C Still, Tyler A Johnson, Marija Drašković

J Nat Prod· March 2015

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Scrutinizing the scaffolds of marine biosynthetics from different source organisms: Gram-negative cultured bacterial products enter center stage.
Patrick C Still, Tyler A Johnson, Christine M Theodore, Steven T Loveridge, Phillip Crews

J Nat Prod· March 2014

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(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
Tyler A Johnson, Johann Sohn, Aidan E Ward, Tanya L Cohen, Nicholas D Lorig-Roach

Bioorg Med Chem· July 2013

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Chemically diverse microtubule stabilizing agents initiate distinct mitotic defects and dysregulated expression of key mitotic kinases.
Cristina C Rohena, Jiangnan Peng, Tyler A Johnson, Phillip Crews, Susan L Mooberry

Biochem Pharmacol· April 2013

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Discovery and development of anticancer agents from marine sponges: perspectives based on a chemistry-experimental therapeutics collaborative program.
Frederick A Valeriote, Karen Tenney, Joseph Media, Halina Pietraszkiewicz, Matthew Edelstein, Tyler A Johnson

J Exp Ther Oncol· February 2013

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Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders.
Tyler A Johnson, Johann Sohn, Wayne D Inman, Leonard F Bjeldanes, Keith Rayburn

Phytomedicine· January 2013

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Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
Tyler A Johnson, Johann Sohn, Yvette M Vaske, Kimberly N White, Tanya L Cohen

Bioorg Med Chem· July 2012

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Natural product libraries to accelerate the high-throughput discovery of therapeutic leads.
Tyler A Johnson, Johann Sohn, Wayne D Inman, Samarkand A Estee, Steven T Loveridge

J Nat Prod· December 2011

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Azonazine, a novel dipeptide from a Hawaiian marine sediment-derived fungus, Aspergillus insulicola.
Quan-Xiang Wu, Mitchell S Crews, Marija Draskovic, Johann Sohn, Tyler A Johnson

Org Lett· October 2010

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The marine sponge metabolite mycothiazole: a novel prototype mitochondrial complex I inhibitor.
J Brian Morgan, Fakhri Mahdi, Yang Liu, Veena Coothankandaswamy, Mika B Jekabsons, Tyler A Johnson

Bioorg Med Chem· August 2010

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Assessing pressurized liquid extraction for the high-throughput extraction of marine-sponge-derived natural products.
Tyler A Johnson, Micaela V C Morgan, Natalie A Aratow, Samarkand A Estee, Koneni V Sashidhara

J Nat Prod· March 2010

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Development and validation of a rapid method for the detection of latrunculol A in plasma.
Jiajiu Shaw, Frederick A Valeriote, Joseph Media, Tyler A Johnson, Taro Amagata

Anal Bioanal Chem· March 2010

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The aignopsanes, a new class of sesquiterpenes from selected chemotypes of the sponge Cacospongia mycofijiensis.
Tyler A Johnson, Taro Amagata, Koneni V Sashidhara, Allen G Oliver, Karen Tenney

Org Lett· May 2009

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