Publications by authors named "Tyler Hilsabeck"

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Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction.
Sudipta Bar, Kenneth A Wilson, Tyler A U Hilsabeck, Sydney Alderfer, Eric B Dammer

Nat Metab· July 2025

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Deep Learning of Cellular Metabolic Flux Distributions Predicts Lifespan.
Tyler A U Hilsabeck, Shane L Rea

bioRxiv· May 2025

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Systems biology approaches identify metabolic signatures of dietary lifespan and healthspan across species.
Tyler A U Hilsabeck, Vikram P Narayan, Kenneth A Wilson, Enrique M Carrera, Daniel Raftery

Nat Commun· October 2024

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OXR1 maintains the retromer to delay brain aging under dietary restriction.
Kenneth A Wilson, Sudipta Bar, Eric B Dammer, Enrique M Carrera, Brian A Hodge, Tyler A U Hilsabeck

Nat Commun· January 2024

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Systems biology and machine learning approaches identify metabolites that influence dietary lifespan and healthspan responses across flies and humans.
Tyler A U Hilsabeck, Vikram P Narayan, Kenneth A Wilson, Enrique Carrera, Daniel Raftery

bioRxiv· December 2023

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Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction.
Sudipta Bar, Kenneth A Wilson, Tyler A U Hilsabeck, Sydney Alderfer, Eric B Dammer

Res Sq· November 2023

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A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response.
Tyler A U Hilsabeck, Ru Liu-Bryan, Tracy Guo, Kenneth A Wilson, Neelanjan Bose

Geroscience· August 2022

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Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience.
Kenneth A Wilson, Manish Chamoli, Tyler A Hilsabeck, Manish Pandey, Sakshi Bansal

Cell Metab· November 2021

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S3QELs protect against diet-induced intestinal barrier dysfunction.
Mark A Watson, Blaine Pattavina, Tyler A U Hilsabeck, Jose Lopez-Dominguez, Pankaj Kapahi

Aging Cell· October 2021

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Mifepristone Increases Life Span of Virgin Female on Regular and High-fat Diet Without Reducing Food Intake.
Gary N Landis, Tyler A U Hilsabeck, Hans S Bell, Tal Ronnen-Oron, Lu Wang

Front Genet· September 2021

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GWAS for Lifespan and Decline in Climbing Ability in Flies upon Dietary Restriction Reveal decima as a Mediator of Insulin-like Peptide Production.
Kenneth A Wilson, Jennifer N Beck, Christopher S Nelson, Tyler A Hilsabeck, Daniel Promislow

Curr Biol· July 2020

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A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.
Sven Lang, Tyler A Hilsabeck, Kenneth A Wilson, Amit Sharma, Neelanjan Bose

PLoS Genet· August 2019

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Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster.
Kazutaka Akagi, Kenneth A Wilson, Subhash D Katewa, Mauricio Ortega, Jesse Simons, Tyler A Hilsabeck

PLoS Genet· November 2018

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The role of mitochondrial dysfunction in age-related diseases.
Rebecca K Lane, Tyler Hilsabeck, Shane L Rea

Biochim Biophys Acta· November 2015

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