Publications by authors named "Tyler Longmire"

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Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies.
Michael Wichroski, Si-Qi Liu, Lauren M Zasadil, Joseph L Benci, Patrick C Gedeon, Tyler A Longmire

Cancer Immunol Res· September 2025

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Correction: Phase I/Ib Clinical Trial of Sabatolimab, an Anti-TIM-3 Antibody, Alone and in Combination with Spartalizumab, an Anti-PD-1 Antibody, in Advanced Solid Tumors.
Giuseppe Curigliano, Hans Curigliano, Nicolas Mach, Toshihiko Doi, David Tai, Tyler A Longmire

Clin Cancer Res· September 2024

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DGKα/ζ inhibition lowers the TCR affinity threshold and potentiates antitumor immunity.
Rakeeb Kureshi, Elisa Bello, Courtney T S Kureshi, Michael J Walsh, Victoria Lippert, Tyler Longmire

Sci Adv· November 2023

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Characterization of sabatolimab, a novel immunotherapy with immuno-myeloid activity directed against TIM-3 receptor.
Stephanie Schwartz, Nidhi Patel, Tyler Longmire, Pushpa Jayaraman, Xiaomo Jiang

Immunother Adv· August 2022

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Phase I/II study of the LAG-3 inhibitor ieramilimab (LAG525) ± anti-PD-1 spartalizumab (PDR001) in patients with advanced malignancies.
Patrick Schöffski, Daniel S W Tan, Miguel Martín, María Ochoa-de-Olza, John Sarantopoulos, Tyler Longmire

J Immunother Cancer· February 2022

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Phase I/Ib Clinical Trial of Sabatolimab, an Anti-TIM-3 Antibody, Alone and in Combination with Spartalizumab, an Anti-PD-1 Antibody, in Advanced Solid Tumors.
Giuseppe Curigliano, Hans Gelderblom, Nicolas Mach, Toshihiko Doi, David Tai, Tyler A Longmire

Clin Cancer Res· July 2021

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Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment.
Hui Qin Wang, Iain J Mulford, Fiona Sharp, Jinsheng Liang, Sema Kurtulus, Tyler A Longmire

Cancer Res· June 2021

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Therapeutic Efficacy of Combined JAK1/2, Pan-PIM, and CDK4/6 Inhibition in Myeloproliferative Neoplasms.
Raajit K Rampal, Maria Pinzon-Ortiz, Amritha Varshini Hanasoge Somasundara, Benjamin Durham, Richard Koche, Tyler Longmire

Clin Cancer Res· June 2021

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Mouse ESC Differentiation to Nkx2.1+ Lung and Thyroid Progenitors.
Tyler A Longmire, Laertis Ikonomou, Darrell N Kotton

Bio Protoc· November 2012

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Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells.
Tyler A Longmire, Laertis Ikonomou, Finn Hawkins, Constantina Christodoulou, Yuxia Cao

Cell Stem Cell· April 2012

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Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes.
Constantina Christodoulou, Tyler A Longmire, Steven S Shen, Alice Bourdon, Cesar A Sommer

J Clin Invest· June 2011

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Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector.
Cesar A Sommer, Andreia Gianotti Sommer, Tyler A Longmire, Constantina Christodoulou, Dolly D Thomas

Stem Cells· January 2010

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