Publications by authors named "Tyrell Simkins"

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Low incidence of atrial fibrillation in patients with obstructive hypertrophic cardiomyopathy treated with aficamten: An analysis from the REDWOOD-HCM, SEQUOIA-HCM, and FOREST-HCM trials.
Ethan J Rowin, Martin S Maron, Iacopo Olivotto, Caroline J Coats, Theodore P Abraham, Tyrell Simkins

Heart Rhythm· January 2026

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Efficacy and Safety of Aficamten in Children and Adolescents With Obstructive Hypertrophic Cardiomyopathy: Study Design and Rationale of CEDAR-HCM.
Juan Pablo Kaski, Paul F Kantor, Stephanie J Nakano, Iacopo Olivotto, Mark W Russell, Tyrell Simkins

Circ Heart Fail· December 2025

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Hospitalizations as an outcome measure in COURAGE-ALS.
Stacy A Rudnicki, Ammar Al-Chalabi, Jinsy A Andrews, Adriano Chio, Philippe Corcia, Tyrell J Simkins

Amyotroph Lateral Scler Frontotemporal Degener· November 2025

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Participant, site personnel and sponsor perspectives on decentralized trial features in COURAGE-ALS: a randomized clinical trial.
Stacy A Rudnicki, Paulos Gebrehiwet, Stuart Kupfer, Fady I Malik, Lisa Meng, Tyrell Simkins

Amyotroph Lateral Scler Frontotemporal Degener· November 2025

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Safety and Efficacy of Aficamten in Patients With Nonobstructive Hypertrophic Cardiomyopathy: A 96-Week Analysis From FOREST-HCM.
Ahmad Masri, Mark V Sherrid, Lubna Choudhury, Pablo Garcia-Pavia, Christopher M Kramer, Tyrell Simkins

J Card Fail· September 2025

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FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult central nervous system.
Hannah Y Collins, Ryan A Doan, Jiaxing Li, Jason E Early, Megan E Madden, Tyrell Simkins

Nat Commun· August 2025

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Reldesemtiv in Amyotrophic Lateral Sclerosis: Results From the COURAGE-ALS Randomized Clinical Trial.
Jeremy M Shefner, Merit E Cudkowicz, Angela Genge, Orla Hardiman, Ammar Al-Chalabi, Tyrell J Simkins

JAMA Neurol· May 2025

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Clinical Evaluation of the Effect of Aficamten on QT/QTc Interval in Healthy Participants.
Neha Maharao, Donghong Xu, Tyrell J Simkins, Owen Bowles, Genzhou Liu

Clin Transl Sci· April 2025

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Plasma neurofilament analysis in VITALITY-ALS.
Tyrell J Simkins, Stuart Kupfer, Fady I Malik, Lisa Meng, Stacy A Rudnicki

Amyotroph Lateral Scler Frontotemporal Degener· February 2025

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FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult CNS.
Hannah Y Collins, Ryan A Doan, Jiaxing Li, Jason E Early, Megan E Madden, Tyrell Simkins

bioRxiv· October 2024

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COURAGE-ALS: a randomized, double-blind phase 3 study designed to improve participant experience and increase the probability of success.
Jeremy M Shefner, Ammar Al-Chalabi, Jinsy A Andrews, Adriano Chio, Mamede De Carvalho, Tyrell J Simkins

Amyotroph Lateral Scler Frontotemporal Degener· August 2023

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Autoimmune disease of head and neck, imaging, and clinical review.
Alireza Paydar, Zachary B Jenner, Tyrell J Simkins, Yu-Ming Chang, Lotfi Hacein-Bey

Neuroradiol J· October 2022

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Autoimmune diseases of the brain, imaging and clinical review.
Ghazal Shadmani, Tyrell J Simkins, Reza Assadsangabi, Michelle Apperson, Lotfi Hacein-Bey

Neuroradiol J· April 2022

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A clinical decision rule predicting outcomes of emergency department patients with altered mental status.
Tyrell J Simkins, David Bissig, Gabriel Moreno, Nimar Pal K Kahlon, Fredric Gorin

J Am Coll Emerg Physicians Open· October 2021

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Chronic Demyelination and Axonal Degeneration in Multiple Sclerosis: Pathogenesis and Therapeutic Implications.
Tyrell J Simkins, Greg J Duncan, Dennis Bourdette

Curr Neurol Neurosci Rep· April 2021

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Neuron-Oligodendrocyte Interactions in the Structure and Integrity of Axons.
Greg J Duncan, Tyrell J Simkins, Ben Emery

Front Cell Dev Biol· March 2021

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Reduced Noradrenergic Signaling in the Spleen Capsule in the Absence of CB and CB Cannabinoid Receptors.
Tyrell J Simkins, David Fried, Kevin Parikh, James J Galligan, John L Goudreau

J Neuroimmune Pharmacol· December 2016

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Enhanced humoral immunity in mice lacking CB1 and CB2 receptors (Cnr1-/-/Cnr2-/- mice) is not due to increased splenic noradrenergic neuronal activity.
Tyrell Simkins, Robert B Crawford, John L Goudreau, Keith J Lookingland, Barbara L F Kaplan

J Neuroimmune Pharmacol· September 2014

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Comparison of the D2 receptor regulation and neurotoxicant susceptibility of nigrostriatal dopamine neurons in wild-type and CB1/CB2 receptor knockout mice.
Tyrell J Simkins, Kelly L Janis, Alison K McClure, Bahareh Behrouz, Samuel S Pappas

J Neuroimmune Pharmacol· September 2012

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Liquid chromatographic-electrospray mass spectrometric determination of 1-methyl-4-phenylpyridine (MPP+) in discrete regions of murine brain.
Andreas Lehner, Margaret Johnson, Tyrell Simkins, Kelly Janis, Keith Lookingland

Toxicol Mech Methods· March 2011

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