Publications by authors named "Tyrell Towle"

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The C7-aminomethylpyrrolidine group rescues the activity of a thio-fluoroquinolone.
Sarah R C Lentz, Pratik R Chheda, Lisa M Oppegard, Tyrell R Towle, Robert J Kerns

Biochimie· May 2019

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Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity.
Lisa M Oppegard, Justine L Delgado, Chaitanya A Kulkarni, Tyrell R Towle, Delaney E Hart

Invest New Drugs· April 2019

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Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase.
Tyrell R Towle, Chaitanya A Kulkarni, Lisa M Oppegard, Bridget P Williams, Taylor A Picha

Bioorg Med Chem Lett· June 2018

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Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site.
Lisa M Oppegard, Heidi A Schwanz, Tyrell R Towle, Robert J Kerns, Hiroshi Hiasa

Biochim Biophys Acta· March 2016

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Bypassing fluoroquinolone resistance with quinazolinediones: studies of drug-gyrase-DNA complexes having implications for drug design.
Karl Drlica, Arkady Mustaev, Tyrell R Towle, Gan Luan, Robert J Kerns

ACS Chem Biol· December 2014

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Chemical probes of a trisubstituted pyrrole to identify its protein target(s) in Plasmodium sporozoites.
Tyrell Towle, Isabell Chang, Robert J Kerns, Purnima Bhanot

Bioorg Med Chem Lett· March 2013

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Hidden histidine radical rearrangements upon electron transfer to gas-phase peptide ions. Experimental evidence and theoretical analysis.
Frantisek Turecek, Jace W Jones, Tyrell Towle, Subhasis Panja, Steen Brøndsted Nielsen

J Am Chem Soc· November 2008

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