Publications by authors named "Tzu-Fun Fu"

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Leveraging the enrichment analysis from a genome-wide association study against epilepsy-focusing on the role of tryptophan catabolites pathway in patients with drug-resistant epilepsy.
Alice Y W Chang, Chin-Wei Huang, Ping-Lin Tsai, Chun-An Liang, Wei Chen Liao, Tzu-Fun Fu

Front Nutr· September 2025

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Disturbed intracellular folate homeostasis impairs autophagic flux and increases hepatocytic lipid accumulation.
Wan-Yu Chi, Gang-Hui Lee, Ming-Jer Tang, Bing-Hung Chen, Wei-Ling Lin, Tzu-Fun Fu

BMC Biol· July 2024

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Correction: Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs.
Gang-Hui Lee, Shian-Ying Sung, Wen-Ni Chang, Tseng-Ting Kao, Hung-Chi Tu, Tzu-Fun Fu

Dis Model Mech· October 2023

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The cooperative interplay among inflammation, necroptosis and YAP pathway contributes to the folate deficiency-induced liver cells enlargement.
Wan-Yu Chi, Tsun-Hsien Hsiao, Gang-Hui Lee, I-Hsiu Su, Bing-Hung Chen, Tzu-Fun Fu

Cell Mol Life Sci· July 2022

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Association between the Serum Coenzyme Q10 Level and Seizure Control in Patients with Drug-Resistant Epilepsy.
Wei-Chen Liao, Chin-Wei Huang, Ya-Hsin Hsiao, Pi-Shan Sung, Tzu-Fun Fu

Healthcare (Basel)· August 2021

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The Incoherent Fluctuation of Folate Pools and Differential Regulation of Folate Enzymes Prioritize Nucleotide Supply in the Zebrafish Model Displaying Folate Deficiency-Induced Microphthalmia and Visual Defects.
Tsun-Hsien Hsiao, Gang-Hui Lee, Yi-Sheng Chang, Bing-Hung Chen, Tzu-Fun Fu

Front Cell Dev Biol· June 2021

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Increased leptin-b expression and metalloprotease expression contributed to the pyridoxine-associated toxicity in zebrafish larvae displaying seizure-like behavior.
Po-Yuan Chen, Yi-Wen Tsai, Alice Yw Chang, Hui-Hua Chang, Ya-Hsin Hsiao, Tzu-Fun Fu

Biochem Pharmacol· December 2020

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Edible additive effects on zebrafish cardiovascular functionality with hydrodynamic assessment.
Yu-Fang Wang, I-Wei Chen, Satishkumar Subendran, Chun-Wei Kang, Bivas Panigrahi, Tzu-Fun Fu

Sci Rep· October 2020

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An Open Pilot Study of the Effect and Tolerability of Add-On Multivitamin Therapy in Patients with Intractable Focal Epilepsy.
Hui Hua Chang, Pi-Shan Sung, Wei Chen Liao, Alice Y W Chang, Ya-Hsin Hsiao, Tzu-Fun Fu

Nutrients· August 2020

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The Effect of the Chorion on Size-Dependent Acute Toxicity and Underlying Mechanisms of Amine-Modified Silver Nanoparticles in Zebrafish Embryos.
Zi-Yu Chen, Nian-Jhen Li, Fong-Yu Cheng, Jian-Feng Hsueh, Chiao-Ching Huang, Fu-I Lu, Tzu-Fun Fu

Int J Mol Sci· April 2020

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Supplementation with 5-formyltetrahydrofolate alleviates ultraviolet B-inflicted oxidative damage in folate-deficient zebrafish.
Hung-Chi Tu, Meng-Yun Lin, Chia-Yang Lin, Tsun-Hsien Hsiao, Zhi-Hong Wen, Tzu-Fun Fu

Ecotoxicol Environ Saf· October 2019

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A novel zebrafish model to emulate lung injury by folate deficiency-induced swim bladder defectiveness and protease/antiprotease expression imbalance.
Gang-Hui Lee, Nai-Wei Cheng, Hsin-Hsuan Yu, Jen-Ning Tsai, Tsunglin Liu, Tzu-Fun Fu

Sci Rep· September 2019

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Pyridoxamine Supplementation Effectively Reverses the Abnormal Phenotypes of Zebrafish Larvae With PNPO Deficiency.
Po-Yuan Chen, Hung-Chi Tu, Verne Schirch, Martin K Safo, Tzu-Fun Fu

Front Pharmacol· September 2019

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A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish.
Gang-Hui Lee, Chia-Lin Chang, Wen-Tai Chiu, Tsun-Hsien Hsiao, Po-Yuan Chen, Tzu-Fun Fu

J Biomed Sci· August 2019

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Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells.
Pao-Lin Kuo, Jie-Yun Tseng, Hau-Inh Chen, Chia-Yun Wu, Hany A Omar, Tzu-Fun Fu

Biochimie· March 2019

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An automatic method to calculate heart rate from zebrafish larval cardiac videos.
Chia-Pin Kang, Hung-Chi Tu, Tzu-Fun Fu, Jhe-Ming Wu, Po-Hsun Chu

BMC Bioinformatics· May 2018

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One crisis, diverse impacts-Tissue-specificity of folate deficiency-induced circulation defects in zebrafish larvae.
Hung-Chi Tu, Gang-Hui Lee, Tsun-Hsien Hsiao, Tseng-Ting Kao, Tzu-Ya Wang, Tzu-Fun Fu

PLoS One· December 2017

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The Transgenic Zebrafish Display Fluorescence Reflecting the Expressional Dynamics of Dihydrofolate Reductase.
Wen-Ni Chang, Wan-Yu Chi, Tseng-Ting Kao, Jen-Ning Tsai, Wangta Liu, Tzu-Fun Fu

Zebrafish· June 2017

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BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model.
Chien-Chih Chiu, Han-Lin Chou, Bing-Hung Chen, Kuo-Feng Chang, Chih-Hua Tseng, Tzu-Fun Fu

BMC Cancer· December 2015

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Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition.
Chien-Chih Lin, Phimonphan Chuankhayan, Wen-Ni Chang, Tseng-Ting Kao, Hong-Hsiang Guan, Hoong-Kun Fun, Tzu-Fun Fu

Acta Crystallogr D Biol Crystallogr· April 2015

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Concentration effects of grape seed extracts in anti-oral cancer cells involving differential apoptosis, oxidative stress, and DNA damage.
Ching-Yu Yen, Ming-Feng Hou, Zhi-Wen Yang, Jen-Yang Tang, Kun-Tzu Li, Tzu-Fun Fu

BMC Complement Altern Med· March 2015

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Aspartic acid-based modified PLGA-PEG nanoparticles for bone targeting: in vitro and in vivo evaluation.
Yin-Chih Fu, Tzu-Fun Fu, Hung-Jen Wang, Che-Wei Lin, Gang-Hui Lee

Acta Biomater· November 2014

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Folate deficiency-induced oxidative stress contributes to neuropathy in young and aged zebrafish--implication in neural tube defects and Alzheimer's diseases.
Tseng-Ting Kao, Chia-Yi Chu, Gang-Hui Lee, Tsun-Hsien Hsiao, Nai-Wei Cheng, Tzu-Fun Fu

Neurobiol Dis· November 2014

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Knocking down 10-Formyltetrahydrofolate dehydrogenase increased oxidative stress and impeded zebrafish embryogenesis by obstructing morphogenetic movement.
Wen-Ni Chang, Gang-Hui Lee, Tseng-Ting Kao, Cha-Ying Lin, Tsun-Hsien Hsiao, Tzu-Fun Fu

Biochim Biophys Acta· July 2014

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Sp1-mediated microRNA-182 expression regulates lung cancer progression.
Wen-Bin Yang, Ping-Hsin Chen, Tsung Hsu, Tzu-Fun Fu, Wu-Chou Su

Oncotarget· February 2014

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