Publications by authors named "Unal Can"

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Results of health technology assessments of orphan drugs in Germany-lack of added benefit, evidence gaps, and persisting unmet medical needs.
Philip Kranz, Natalie McGauran, Can Ünal, Thomas Kaiser

Int J Technol Assess Health Care· December 2024

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[4.3.1]Bicyclic FKBP Ligands Inhibit Legionella Pneumophila Infection by LpMip-Dependent and LpMip-Independent Mechanisms.
Robin C E Deutscher, M Safa Karagöz, Patrick L Purder, Jürgen M Kolos, Christian Meyners, Can Ünal

Chembiochem· November 2023

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Reforming EU and national orphan drug regulations to improve outcomes for patients with rare diseases.
Philip Kranz, Natalie McGauran, Rita Banzi, Can Ünal, Fabian Lotz

BMJ· May 2023

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Legionella pneumophila PPIase Mip Interacts with the Bacterial Proteins SspB, Lpc2061, and FlaA and Promotes Flagellation.
Mustafa Safa Karagöz, Can Murat Ünal, Benjamin E Mayer, Mathias Müsken, José Manuel Borrero-de Acuña

Infect Immun· November 2022

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Zinc Metalloprotease ProA from Inhibits the Pro-Inflammatory Host Response by Degradation of Bacterial Flagellin.
Lina Scheithauer, Stefanie Thiem, Can M Ünal, Ansgar Dellmann, Michael Steinert

Biomolecules· April 2022

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Cellular adaptation of Clostridioides difficile to high salinity encompasses a compatible solute-responsive change in cell morphology.
Annika-Marisa Michel, José Manuel Borrero-de Acuña, Gabriella Molinari, Can Murat Ünal, Sabine Will

Environ Microbiol· March 2022

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Zinc metalloprotease ProA of Legionella pneumophila increases alveolar septal thickness in human lung tissue explants by collagen IV degradation.
Lina Scheithauer, Stefanie Thiem, Stefan Schmelz, Ansgar Dellmann, Konrad Büssow, Can M Ünal

Cell Microbiol· May 2021

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Evaluation of dynamic thiol-disulphide homeostasis in obstructive uropathy.
Emre Tokuc, Ahmet Urkmez, Unal Can, Rahime Orak, Gulistan Gumrukcu, Ozcan Erel

Int Urol Nephrol· May 2020

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Development of a Larval Zebrafish Infection Model for Clostridioides difficile.
Junkai Li, Can M Ünal, Kazuhiko Namikawa, Michael Steinert, Reinhard W Köster

J Vis Exp· February 2020

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Pleiotropic Cyclophilin PpiB Controls Cysteine-Tolerance, Toxin Production, the Central Metabolism and Multiple Stress Responses.
Can Murat Ünal, Mustafa Safa Karagöz, Mareike Berges, Christina Priebe, José Manuel Borrero de Acuña

Front Pharmacol· April 2019

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PrsA2 (CD630_35000) of Is an Active Parvulin-Type PPIase and a Virulence Modulator.
Can Murat Ünal, Mareike Berges, Nathiana Smit, Cordelia Schiene-Fischer, Christina Priebe

Front Microbiol· December 2018

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Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins.
Sebastian Pomplun, Claudia Sippel, Andreas Hähle, Donald Tay, Kensuke Shima, Can Murat Ünal

J Med Chem· April 2018

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PilY1 Promotes Infection of Human Lung Tissue Explants and Contributes to Bacterial Adhesion, Host Cell Invasion, and Twitching Motility.
Julia Hoppe, Can M Ünal, Stefanie Thiem, Louisa Grimpe, Torsten Goldmann

Front Cell Infect Microbiol· June 2017

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Novel therapeutic strategies for Clostridium difficile infections.
Can M Ünal, Michael Steinert

Expert Opin Ther Targets· September 2016

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Legionella-protozoa-nematode interactions in aquatic biofilms and influence of Mip on Caenorhabditis elegans colonization.
Janine Rasch, Stefanie Krüger, Dominique Fontvieille, Can M Ünal, Rolf Michel

Int J Med Microbiol· September 2016

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Intrathoracic toxic thyroid nodule causing hyperthyroidism with a multinodular normal functional cervical thyroid gland.
Burcu Dirlik Serim, Ulku Korkmaz, Unal Can, Gulay Durmus Altun

Indian J Nucl Med· July 2016

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Impact evaluation of Swiss Medical Board reports on routine care in Switzerland: a case study of PSA screening and treatment for rupture of anterior cruciate ligament.
Klaus Eichler, Sascha Hess, Marco Riguzzi, Ünal Can, Urs Brügger

Swiss Med Wkly· January 2016

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FKBPs in bacterial infections.
Can M Ünal, Michael Steinert

Biochim Biophys Acta· October 2015

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Detailed polymorphism study on cytomegalovirus DNA polymerase gene to reveal the most suitable genomic targets for quantitative Real-time PCR.
Onur Bilenoğlu, Mustafa Altındiş, Ersoy Öz, Yeliz Yücel-Öz, Öykü İrigül-Sönmez, Can Bora Ünal

Bosn J Basic Med Sci· June 2015

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Novel Cycloheximide Derivatives Targeting the Moonlighting Protein Mip Exhibit Specific Antimicrobial Activity Against Legionella pneumophila.
Janine Rasch, Martin Theuerkorn, Can Ünal, Natascha Heinsohn, Stefan Tran

Front Bioeng Biotechnol· April 2015

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The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions.
Qiuhong Xiong, Can Ünal, Jan Matthias, Michael Steinert, Ludwig Eichinger

Open Biol· April 2015

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Peptidylprolyl cis-trans isomerases of Legionella pneumophila: virulence, moonlighting and novel therapeutic targets.
Janine Rasch, Can M Ünal, Michael Steinert

Biochem Soc Trans· December 2014

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Polyketide synthase (PKS) reduces fusion of Legionella pneumophila-containing vacuoles with lysosomes and contributes to bacterial competitiveness during infection.
Olga Shevchuk, Dennis Pägelow, Janine Rasch, Simon Döhrmann, Gabriele Günther, Can Murat Ünal

Int J Med Microbiol· November 2014

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Microbial peptidyl-prolyl cis/trans isomerases (PPIases): virulence factors and potential alternative drug targets.
Can M Ünal, Michael Steinert

Microbiol Mol Biol Rev· September 2014

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QseC controls biofilm formation of non-typeable Haemophilus influenzae in addition to an AI-2-dependent mechanism.
Can M Unal, Birendra Singh, Christophe Fleury, Kalpana Singh, Luis Chávez de Paz

Int J Med Microbiol· November 2012

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