Publications by authors named "Urs Hancox"

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Inhibiting PI3Kβ with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors.
James T Lynch, Urszula M Polanska, Oona Delpuech, Urs Hancox, Antonio G Trinidad

Clin Cancer Res· December 2017

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The use of 18F-Fluoro-deoxy-glucose positron emission tomography (18F-FDG PET) as a non-invasive pharmacodynamic biomarker to determine the minimally pharmacologically active dose of AZD8835, a novel PI3Kα inhibitor.
Juliana Maynard, Sally-Ann Emmas, Francois-Xavier Ble, Herve Barjat, Emily Lawrie, Urs Hancox

PLoS One· October 2017

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Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors.
Bernard Barlaam, Sabina Cosulich, Martina Fitzek, Hervé Germain, Stephen Green, Urs Hancox

Bioorg Med Chem Lett· July 2017

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Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours.
Bernard Barlaam, Sabina Cosulich, Sébastien Degorce, Rebecca Ellston, Martina Fitzek, Urs Hancox

Bioorg Med Chem Lett· May 2017

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The use of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) as a pathway-specific biomarker with AZD8186, a PI3Kβ/δ inhibitor.
Juliana Maynard, Sally-Ann Emmas, Francois-Xavier Blé, Hervé Barjat, Emily Lawrie, Urs Hancox

EJNMMI Res· December 2016

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Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for PIK3CA-Dependent Breast Cancers.
Kevin Hudson, Urs J Hancox, Cath Trigwell, Robert McEwen, Urszula M Polanska

Mol Cancer Ther· May 2016

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Discovery of a series of 8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours.
Bernard Barlaam, Sabina Cosulich, Sébastien Degorce, Martina Fitzek, Stephen Green, Urs Hancox

Bioorg Med Chem Lett· May 2016

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Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers.
Bernard Barlaam, Sabina Cosulich, Bénédicte Delouvrié, Rebecca Ellston, Martina Fitzek, Urs Hancox

Bioorg Med Chem Lett· November 2015

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Inhibition of PI3Kβ signaling with AZD8186 inhibits growth of PTEN-deficient breast and prostate tumors alone and in combination with docetaxel.
Urs Hancox, Sabina Cosulich, Lyndsey Hanson, Cath Trigwell, Carol Lenaghan

Mol Cancer Ther· January 2015

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Discovery of (R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): a potent and selective inhibitor of PI3Kβ and PI3Kδ for the treatment of PTEN-deficient cancers.
Bernard Barlaam, Sabina Cosulich, Sébastien Degorce, Martina Fitzek, Stephen Green, Urs Hancox

J Med Chem· January 2015

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Feedback suppression of PI3Kα signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kβ.
Sarit Schwartz, John Wongvipat, Cath B Trigwell, Urs Hancox, Brett S Carver

Cancer Cell· January 2015

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Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours.
Bernard Barlaam, Sabina Cosulich, Sébastien Degorce, Martina Fitzek, Fabrizio Giordanetto, Urs Hancox

Bioorg Med Chem Lett· August 2014

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Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer.
Robert H Bradbury, Neil J Hales, Alfred A Rabow, Graeme E Walker, David G Acton, Urs J Hancox

Bioorg Med Chem Lett· September 2011

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Synthesis and structure-activity relationships of thieno[2,3-b]pyrroles as antagonists of the GnRH receptor.
Jean Claude Arnould, Bénédicte Delouvrié, Pascal Boutron, Al G Dossetter, Kevin M Foote, Urs Hancox

Bioorg Med Chem Lett· December 2007

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