Publications by authors named "Uwe Reusch"

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The bispecific innate cell engager AFM28 eliminates CD123 leukemic stem and progenitor cells in AML and MDS.
Nanni Schmitt, Jana-Julia Siegler, Alexandra Beck, Thomas Müller, Izabela Kozlowska, Uwe Reusch

Nat Commun· August 2025

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A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma.
Satoko Kakiuchi-Kiyota, Thorsten Ross, Heidi Ackerly Wallweber, James R Kiefer, Melissa M Schutten, Uwe Reusch

Leukemia· April 2022

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Cryopreservation of Natural Killer Cells Pre-Complexed with Innate Cell Engagers.
Uwe Reusch, Kristina Ellwanger, Ivica Fucek, Thomas Müller, Ute Schniegler-Mattox

Antibodies (Basel)· February 2022

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Preclinical evaluation of AFM24, a novel CD16A-specific innate immune cell engager targeting EGFR-positive tumors.
Susanne Wingert, Uwe Reusch, Stefan Knackmuss, Michael Kluge, Michael Damrat

MAbs· January 2022

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Redirected optimized cell killing (ROCK®): A highly versatile multispecific fit-for-purpose antibody platform for engaging innate immunity.
Kristina Ellwanger, Uwe Reusch, Ivica Fucek, Susanne Wingert, Thorsten Ross

MAbs· July 2019

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Functionally Defective T Cells After Chemotherapy of B-Cell Malignancies Can Be Activated by the Tetravalent Bispecific CD19/CD3 Antibody AFM11.
Johannes Duell, Dragana S Lukic, Margarete Karg, Uwe Reusch, Joachim Koch

J Immunother· June 2019

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CD16A Activation of NK Cells Promotes NK Cell Proliferation and Memory-Like Cytotoxicity against Cancer Cells.
Jens H W Pahl, Joachim Koch, Jana-Julia Götz, Annette Arnold, Uwe Reusch

Cancer Immunol Res· May 2018

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Adhesion and Invasion of Breast and Oesophageal Cancer Cells Are Impeded by Anti-LRP/LR-Specific Antibody IgG1-iS18.
Thandokuhle Khumalo, Uwe Reusch, Stefan Knackmuss, Melvyn Little, Robin B Veale

PLoS One· October 2017

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Trispecific antibodies for CD16A-directed NK cell engagement and dual-targeting of tumor cells.
Thorsten Gantke, Michael Weichel, Carmen Herbrecht, Uwe Reusch, Kristina Ellwanger

Protein Eng Des Sel· September 2017

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Highly Specific and Effective Targeting of EGFRvIII-Positive Tumors with TandAb Antibodies.
Kristina Ellwanger, Uwe Reusch, Ivica Fucek, Stefan Knackmuss, Michael Weichel

Front Oncol· May 2017

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Characterization of CD33/CD3 Tetravalent Bispecific Tandem Diabodies (TandAbs) for the Treatment of Acute Myeloid Leukemia.
Uwe Reusch, Kimberly H Harrington, Chelsea J Gudgeon, Ivica Fucek, Kristina Ellwanger

Clin Cancer Res· December 2016

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LRP/LR Antibody Mediated Rescuing of Amyloid-β-Induced Cytotoxicity is Dependent on PrPc in Alzheimer's Disease.
Emma C Pinnock, Katarina Jovanovic, Maxine G Pinto, Eloise Ferreira, Bianca Da Costa Dias, Uwe Reusch

J Alzheimers Dis· November 2016

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Knock-Down of the 37kDa/67kDa Laminin Receptor LRP/LR Impedes Telomerase Activity.
Kerrilyn Naidoo, Sibusiso T Malindisa, Tyrone C Otgaar, Martin Bernert, Bianca Da Costa Dias, Uwe Reusch

PLoS One· June 2016

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A tetravalent bispecific TandAb (CD19/CD3), AFM11, efficiently recruits T cells for the potent lysis of CD19(+) tumor cells.
Uwe Reusch, Johannes Duell, Kristina Ellwanger, Carmen Herbrecht, Stefan Hj Knackmuss

MAbs· March 2016

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Anti-LRP/LR specific antibody IgG1-iS18 impedes adhesion and invasion of liver cancer cells.
Carryn Chetty, Thandokuhle Khumalo, Bianca Da Costa Dias, Uwe Reusch, Stefan Knackmuss

PLoS One· July 2015

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A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells.
Uwe Reusch, Carmen Burkhardt, Ivica Fucek, Fabrice Le Gall, Mikaelle Le Gall

MAbs· May 2015

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The 37kDa/67kDa laminin receptor acts as a receptor for Aβ42 internalization.
Bianca Da Costa Dias, Katarina Jovanovic, Danielle Gonsalves, Kiashanee Moodley, Uwe Reusch

Sci Rep· July 2014

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Anti-LRP/LR specific antibody IgG1-iS18 and knock-down of LRP/LR by shRNAs rescue cells from Aβ42 induced cytotoxicity.
Bianca Da Costa Dias, Katarina Jovanovic, Danielle Gonsalves, Kiashanee Moodley, Uwe Reusch

Sci Rep· June 2014

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Anti-LRP/LR specific antibodies and shRNAs impede amyloid beta shedding in Alzheimer's disease.
Katarina Jovanovic, Danielle Gonsalves, Bianca Da Costa Dias, Kiashanee Moodley, Uwe Reusch

Sci Rep· June 2014

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In vitro inhibition of angiogenesis by antibodies directed against the 37kDa/67kDa laminin receptor.
Raksha Khusal, Bianca Da Costa Dias, Kiashanee Moodley, Clement Penny, Uwe Reusch

PLoS One· October 2013

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Rescue of impaired NK cell activity in hodgkin lymphoma with bispecific antibodies in vitro and in patients.
Katrin S Reiners, Jörg Kessler, Maike Sauer, Achim Rothe, Hinrich P Hansen, Uwe Reusch

Mol Ther· April 2013

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T and NK cells of B cell NHL patients exert cytotoxicity against lymphoma cells following binding of bispecific tetravalent antibody CD19 × CD3 or CD19 × CD16.
Lisa M Pörtner, Kathrin Schönberg, Maryam Hejazi, Daniela Brünnert, Frank Neumann, Uwe Reusch

Cancer Immunol Immunother· October 2012

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WITHDRAWN: Tetravalent Bispecific Single-Chain Fv Antibodies for Lysis of Leukemia Cells by Autologous T Cells.
Fabrice Le Gall, Uwe Reusch, Anastasia Y Bakulina, Sergej M Kiprijanov

J Mol Biol· September 2012

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Anti-LRP/LR-specific antibody IgG1-iS18 significantly reduces adhesion and invasion of metastatic lung, cervix, colon and prostate cancer cells.
Aadilah Omar, Uwe Reusch, Stefan Knackmuss, Melvyn Little, Stefan F T Weiss

J Mol Biol· May 2012

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68Ga-labelled recombinant antibody variants for immuno-PET imaging of solid tumours.
Matthias Eder, Stefan Knackmuss, Fabrice Le Gall, Uwe Reusch, Vladimir Rybin

Eur J Nucl Med Mol Imaging· July 2010

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