Publications by authors named "Vadim Markovtsov"

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UBE2N Is Essential for Maintenance of Skin Homeostasis and Suppression of Inflammation.
Min Jin Lee, Manel Ben Hammouda, Wanying Miao, Arinze E Okafor, Yingai J Jin, Vadim Markovtsov

J Invest Dermatol· December 2024

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Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib.
Nichola Cooper, Waleed Ghanima, Quentin A Hill, Phillip Lr Nicolson, Vadim Markovtsov

Platelets· December 2023

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Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators.
Simon J Shaw, Dane A Goff, Luke A Boralsky, Rajinder Singh, David J Sweeny, Vadim Markovtsov

J Med Chem· December 2023

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UBE2N is essential for maintenance of skin homeostasis and suppression of inflammation.
Min Jin Lee, Manel Ben Hammouda, Wanying Miao, Arinze Okafor, Yingai Jin, Vadim Markovtsov

bioRxiv· December 2023

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Tuning the Reactivity of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Optimal Efficacy.
Vadim Markovtsov, Matthew A J Duncton, Art Bagos, Sothy Yi, Sylvia Braselmann

ACS Med Chem Lett· December 2023

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Structure activity relationships leading to the identification of the indirect activator of AMPK, R419.
Simon J Shaw, Dane A Goff, David C Carroll, Rajinder Singh, David J Sweeny, Vadim Markovtsov

Bioorg Med Chem· October 2022

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Assessment of thrombotic risk during long-term treatment of immune thrombocytopenia with fostamatinib.
Nichola Cooper, Ivy Altomare, Mark R Thomas, Phillip L R Nicolson, Steve P Watson, Vadim Markovtsov

Ther Adv Hematol· April 2021

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Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: Results of two phase 3, randomized, placebo-controlled trials.
James Bussel, Donald M Arnold, Elliot Grossbard, Jiří Mayer, Jacek Treliński, Vadim Markovtsov

Am J Hematol· July 2018

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AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes.
Yonchu Jenkins, Tian-Qiang Sun, Vadim Markovtsov, Marc Foretz, Wei Li

PLoS One· September 2014

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Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective alterations in metabolic pathways.
Yonchu Jenkins, Tian-Qiang Sun, Yingwu Li, Vadim Markovtsov, Gerald Uy

BMC Res Notes· September 2014

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Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice.
Kristen A Baltgalvis, Kathy White, Wei Li, Mark D Claypool, Wayne Lang, Vadim Markovtsov

Am J Physiol Heart Circ Physiol· April 2014

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R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm.
Kotaro Shide, Takuro Kameda, Vadim Markovtsov, Haruko K Shimoda, Elizabeth Tonkin

Blood· June 2011

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The current status and the future of JAK2 inhibitors for the treatment of myeloproliferative diseases.
Yasumichi Hitoshi, Nan Lin, Donald G Payan, Vadim Markovtsov

Int J Hematol· March 2010

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Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen.
John McLaughlin, Vadim Markovtsov, Hui Li, Steve Wong, Marina Gelman

J Cancer Res Clin Oncol· January 2010

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Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth.
Yonchu Jenkins, Vadim Markovtsov, Wayne Lang, Poonam Sharma, Denise Pearsall

Mol Biol Cell· December 2005

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Exon repression by polypyrimidine tract binding protein.
Batoul Amir-Ahmady, Paul L Boutz, Vadim Markovtsov, Martin L Phillips, Douglas L Black

RNA· May 2005

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Strategies and methods of cross-linking of RNA polymerase active center.
Arkadv Mustaev, Eugeny Zaychikov, Mikhail Grachev, Maxim Kozlov, Konstantin Severinov, Vadim Markovtsov

Methods Enzymol· February 2004

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Roles for SR proteins and hnRNP A1 in the regulation of c-src exon N1.
Nanette Rooke, Vadim Markovtsov, Esra Cagavi, Douglas L Black

Mol Cell Biol· March 2003

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Swing-gate model of nucleotide entry into the RNA polymerase active center.
Vitaliy Epshtein, Arkady Mustaev, Vadim Markovtsov, Oxana Bereshchenko, Vadim Nikiforov

Mol Cell· September 2002

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