Publications by authors named "Valerie Sim"

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Perceptions and experiences of pain management and opioid use among orthopaedic patients and health professionals: Insights from a qualitative study in a metropolitan tertiary hospital.
Sally B Marotti, Jonathan Beacham, Jennifer Collins, Valerie Sim, Peter White

SAGE Open Med· December 2025

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Gangliosides modulate the secretion of extracellular vesicles and their misfolded protein cargo.
John Monyror, Vaibhavi Kadam, Luis Carlos Morales, Diego Ordóñez, Jeremies Ibanga, Valerie L Sim, Simonetta Sipione

Sci Adv· September 2025

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Temperature-Dependent Aggregation of Tau Protein Is Attenuated by Native PLGA Nanoparticles Under in vitro Conditions.
Pallabi Sil Paul, Mallesh Rathnam, Aria Khalili, Leonardo M Cortez, Mahalashmi Srinivasan, Valerie L Sim

Int J Nanomedicine· May 2025

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Distinct patterns of prion strain deposition and toxicity in a novel whole brain organotypic slice culture system.
Hailey Pineau, Valerie L Sim

Sci Rep· February 2025

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PrP is cleaved from the surface of mast cells by ADAM10 and proteases released during degranulation.
Steven D Willows, Harissios Vliagoftis, Valerie L Sim, Marianna Kulka

J Leukoc Biol· October 2024

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Histamine stimulates human microglia to alter cellular prion protein expression via the HRH2 histamine receptor.
Marcus Pehar, Melissa Hewitt, Ashley Wagner, Jagdeep K Sandhu, Aria Khalili, Valerie L Sim

Sci Rep· October 2024

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Rational design of structure-based vaccines targeting misfolded alpha-synuclein conformers of Parkinson's disease and related disorders.
Jose Miguel Flores-Fernandez, Verena Pesch, Aishwarya Sriraman, Enrique Chimal-Juarez, Sara Amidian, Valerie L Sim

Bioeng Transl Med· July 2024

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Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice.
Ghazaleh Eskandari-Sedighi, Madeline Crichton, Sameera Zia, Erik Gomez-Cardona, Leonardo M Cortez, Valerie L Sim

Mol Neurodegener· May 2024

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In Vitro and In Vivo Evidence towards Fibronectin's Protective Effects against Prion Infection.
M Carmen Garza, Sang-Gyun Kang, Chiye Kim, Eva Monleón, Jacques van der Merwe, Valerie L Sim

Int J Mol Sci· December 2023

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Mast Cell Proteases Cleave Prion Proteins and a Recombinant Ig against PrP Can Activate Human Mast Cells.
Steven D Willows, Valentyna Semenchenko, Grant Norman, Michael T Woodside, Valerie L Sim

J Immunol· May 2023

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Probing the origin of prion protein misfolding via reconstruction of ancestral proteins.
Leonardo M Cortez, Anneliese J Morrison, Craig R Garen, Sawyer Patterson, Toshi Uyesugi, Valerie L Sim

Protein Sci· December 2022

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Visual Disturbances and Headache as Presenting Symptoms of Creutzfeldt-Jakob Disease.
Natalia M Binczyk, Meghan J Smith, Nabeela Nathoo, Valerie L Sim, Dean Jeffery

J Neuroophthalmol· June 2022

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Creutzfeldt-Jakob disease in pregnancy: the use of modified RT-QuIC to determine infectivity in placental tissues.
Collin C Luk, Candace K Mathiason, Christina D Orrù, Gerard H Jansen, Allison Thiele, Valerie L Sim

Prion· December 2021

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Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology.
Qi Wu, Leonardo Cortez, Razieh Kamali-Jamil, Valerie Sim, Holger Wille

Dis Model Mech· October 2021

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TREM2 expression in the brain and biological fluids in prion diseases.
Daniela Diaz-Lucena, Niels Kruse, Katrin Thüne, Matthias Schmitz, Anna Villar-Piqué, Valerie Sim

Acta Neuropathol· June 2021

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Asymmetric-flow field-flow fractionation of prions reveals a strain-specific continuum of quaternary structures with protease resistance developing at a hydrodynamic radius of 15 nm.
Leonardo M Cortez, Satish K Nemani, Camilo Duque Velásquez, Aishwarya Sriraman, YongLiang Wang, Valerie L Sim

PLoS Pathog· June 2021

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Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice.
Tahir Ali, Samia Hannaoui, Satish Nemani, Waqas Tahir, Irina Zemlyankina, Valerie Sim

Acta Neuropathol Commun· April 2021

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Quaternary Structure Changes for PrP Predate PrP Downregulation and Neuronal Death During Progression of Experimental Scrapie Disease.
Ghazaleh Eskandari-Sedighi, Leonardo M Cortez, Jing Yang, Nathalie Daude, Klinton Shmeit, Valerie Sim

Mol Neurobiol· January 2021

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From Cell Culture to Organoids-Model Systems for Investigating Prion Strain Characteristics.
Hailey Pineau, Valerie L Sim

Biomolecules· January 2021

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Creutzfeldt-Jakob Disease with a Five-Year Clinical Course, Multicentric Cerebellar Prion Plaques and Prior History of Biopsy-Proven Primary Angiitis of the Central Nervous System: A Case for Iatrogenic Exposure?
Kristina Jeon, Jeffrey T Joseph, Gerard H Jansen, Anne Peterson, J David Knox, Valerie L Sim

Viruses· December 2020

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Exposure Risk of Chronic Wasting Disease in Humans.
Satish K Nemani, Jennifer L Myskiw, Lise Lamoureux, Stephanie A Booth, Valerie L Sim

Viruses· December 2020

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Effectiveness of multimedia interventions in the provision of patient education on anticoagulation therapy: A review.
Valerie Sim, Kirsten Galbraith

Patient Educ Couns· October 2020

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POSCAbilities: The Application of the Prion Organotypic Slice Culture Assay to Neurodegenerative Disease Research.
Hailey Pineau, Valerie Sim

Biomolecules· July 2020

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Native nanodiscs formed by styrene maleic acid copolymer derivatives help recover infectious prion multimers bound to brain-derived lipids.
Mansoore Esmaili, Brian P Tancowny, Xiongyao Wang, Audric Moses, Leonardo M Cortez, Valerie L Sim

J Biol Chem· June 2020

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A novel mechanism of phenotypic heterogeneity in Creutzfeldt-Jakob disease.
Satish K Nemani, Xiangzhu Xiao, Ignazio Cali, Laura Cracco, Gianfranco Puoti, Massimiliano Nigro, Valerie L Sim

Acta Neuropathol Commun· June 2020

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