Publications by authors named "Vicky MacRae"

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ENPP1 Inhibition: A Promising Oral Therapy for Later-Onset Hypophosphatasia.
Vicky E MacRae

J Bone Miner Res· October 2025

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Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.
Qiyu Tang, Keyi Tang, Greg R Markby, Maciej Parys, Kanchan Phadwal, Vicky E MacRae

Autophagy· July 2025

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Mitochondrial dysfunction and mitophagy blockade contribute to renal osteodystrophy in chronic kidney disease-mineral bone disorder.
Shun-Neng Hsu, Louise A Stephen, Kanchan Phadwal, Scott Dillon, Roderick Carter, Vicky E Macrae

Kidney Int· June 2025

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Rapamycin induced autophagy enhances lipid breakdown and ameliorates lipotoxicity in Atlantic salmon cells.
Kanchan Phadwal, Jennifer Haggarty, Dominic Kurian, Judit Aguilar Martí, Jianxuan Sun, Vicky E MacRae

Biochim Biophys Acta Mol Cell Biol Lipids· June 2025

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The N6-methyladenosine demethylase ALKBH5 is a novel epigenetic regulator of aortic valve calcification.
Yueheng Wang, Shengping He, Lan Lan, Hongjiao Yu, Huan Zhao, Vicky E Macrae

Cardiovasc Res· April 2025

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Sirt7 protects against vascular calcification via modulation of reactive oxygen species and senescence of vascular smooth muscle cells.
Hongjiao Yu, Yuchen Xie, Lan Lan, Siyu Ma, Simon Wing Fai Mok, Vicky E Macrae

Free Radic Biol Med· October 2024

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Mitochondrial Dysfunction as a Potential Mechanism Mediating Cardiac Comorbidities in Parkinson's Disease.
Agustina Salis Torres, Ji-Eun Lee, Andrea Caporali, Robert K Semple, Mathew H Horrocks, Vicky E MacRae

Int J Mol Sci· October 2024

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The Adaptive Immune System: A New Pseudoxanthoma Elasticum Protagonist?
Vicky E MacRae

J Invest Dermatol· August 2024

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PFKFB3-driven vascular smooth muscle cell glycolysis promotes vascular calcification via the altered FoxO3 and lactate production.
Jiaxin Chen, Hongjiao Yu, Xiao Tan, Simon Wing Fai Mok, Yuchen Xie, Vicky E Macrae

FASEB J· October 2023

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TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.
Andrew J McNair, Greg R Markby, Qiyu Tang, Vicky E MacRae, Brendan M Corcoran

Front Vet Sci· October 2023

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TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.
Qiyu Tang, Greg R Markby, Andrew J MacNair, Keyi Tang, Michal Tkacz, Vicky E MacRae

Cell Prolif· June 2023

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Bone mineralisation and glucose metabolism.
Fiona L Roberts, Vicky E MacRae

Curr Opin Endocr Metab Res· April 2023

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Increased PHOSPHO1 and alkaline phosphatase expression during the anabolic bone response to intermittent parathyroid hormone delivery.
Dean A Houston, Louise A Stephen, Soher N Jayash, Katherine Myers, Kirsty Little, Vicky E MacRae

Cell Biochem Funct· March 2023

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p53 Regulates Mitochondrial Dynamics in Vascular Smooth Muscle Cell Calcification.
Kanchan Phadwal, Qi-Yu Tang, Ineke Luijten, Jin-Feng Zhao, Brendan Corcoran, Vicky E MacRae

Int J Mol Sci· January 2023

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Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor.
Kanchan Phadwal, Eve Koo, Ross A Jones, Rachael O Forsythe, Keyi Tang, Vicky E MacRae

J Cell Physiol· November 2022

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Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophy.
Shun-Neng Hsu, Louise A Stephen, Scott Dillon, Elspeth Milne, Behzad Javaheri, Vicky E MacRae

J Endocrinol· September 2022

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Editorial: Vascular smooth muscle cell fate and vascular remodeling: Mechanisms, therapeutic targets, and drugs, volume I.
Qilong Wang, Xiaoyan Dai, Vicky E MacRae, Ping Song

Front Pharmacol· August 2022

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PALMD regulates aortic valve calcification via altered glycolysis and NF-κB-mediated inflammation.
Siying Wang, Hongjiao Yu, Jun Gao, Jiaxin Chen, Pengcheng He, Vicky E Macrae

J Biol Chem· May 2022

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Diagnosing, managing and preventing urinary tract infections in older people with dementia in hospital.
Vicky MacRae, Susan Holland, Rachel MacLeod

Nurs Older People· May 2022

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The Role of Transforming Growth Factor-β Signaling in Myxomatous Mitral Valve Degeneration.
Qiyu Tang, Andrew J McNair, Kanchan Phadwal, Vicky E Macrae, Brendan M Corcoran

Front Cardiovasc Med· May 2022

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Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair.
Shen Li, Tomohiro Yokota, Ping Wang, Johanna Ten Hoeve, Feiyang Ma, Vicky E MacRae

J Clin Invest· January 2022

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Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice.
Fiona L Roberts, Nabil A Rashdan, Kanchan Phadwal, Greg R Markby, Scott Dillon, Vicky E MacRae

J Cell Physiol· June 2021

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Mitochondrial Dysfunction: Cause or Consequence of Vascular Calcification?
Kanchan Phadwal, Christina Vrahnas, Ian G Ganley, Vicky E MacRae

Front Cell Dev Biol· March 2021

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Ex vivo F-fluoride uptake and hydroxyapatite deposition in human coronary atherosclerosis.
Alastair J Moss, Alisia M Sim, Philip D Adamson, Michael A Seidman, Jack P M Andrews, Vicky E MacRae

Sci Rep· November 2020

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Expression of Calcification and Extracellular Matrix Genes in the Cardiovascular System of the Healthy Domestic Sheep ().
Hiu-Gwen Tsang, Emily L Clark, Greg R Markby, Stephen J Bush, David A Hume, Vicky E MacRae

Front Genet· September 2020

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