Publications by authors named "Vojtech Vyklicky"

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Subtype-specific conformational landscape of NMDA receptor gating.
Julia Bleier, Philipe Ribeiro Furtado de Mendonca, Chris H Habrian, Cherise Stanley, Vojtech Vyklicky

Cell Rep· August 2024

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Conformational basis of subtype-specific allosteric control of NMDA receptor gating.
Julia Bleier, Philipe Ribeiro Furtado de Mendonca, Chris Habrian, Cherise Stanley, Vojtech Vyklicky

bioRxiv· February 2024

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Effects of Pregnanolone Glutamate and Its Metabolites on GABA and NMDA Receptors and Zebrafish Behavior.
Vera Abramova, Vanessa Leal Alvarado, Martin Hill, Tereza Smejkalova, Michal Maly, Vojtech Vyklicky, Ladislav Vyklicky

ACS Chem Neurosci· May 2023

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Pregnane-based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss-of-function disease-associated GRIN mutations.
Bohdan Kysilov, Barbora Hrcka Krausova, Vojtech Vyklicky, Tereza Smejkalova, Miloslav Korinek, Ladislav Vyklicky

Br J Pharmacol· August 2022

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Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia.
Kristina Holubova, Marketa Chvojkova, Barbora Hrcka Krausova, Vojtech Vyklicky, Eva Kudova, Ladislav Vyklicky

Biomolecules· July 2021

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Conformational rearrangement of the NMDA receptor amino-terminal domain during activation and allosteric modulation.
Vojtech Vyklicky, Cherise Stanley, Chris Habrian, Ehud Y Isacoff

Nat Commun· May 2021

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Palmitoylation Controls NMDA Receptor Function and Steroid Sensitivity.
Pavla Hubalkova, Marek Ladislav, Vojtech Vyklicky, Tereza Smejkalova, Barbora Hrcka Krausova, Ladislav Vyklicky

J Neurosci· March 2021

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Site of Action of Brain Neurosteroid Pregnenolone Sulfate at the N-Methyl-D-Aspartate Receptor.
Barbora Hrcka Krausova, Bohdan Kysilov, Jiri Cerny, Vojtech Vyklicky, Tereza Smejkalova, Ladislav Vyklicky

J Neurosci· July 2020

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Conformational pathway provides unique sensitivity to a synaptic mGluR.
Chris H Habrian, Joshua Levitz, Vojtech Vyklicky, Zhu Fu, Adam Hoagland

Nat Commun· December 2019

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Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor.
Prashant C Donthamsetti, Johannes Broichhagen, Vojtech Vyklicky, Cherise Stanley, Zhu Fu

J Am Chem Soc· July 2019

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Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of -Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif.
Santosh Kumar Adla, Barbora Slavikova, Hana Chodounska, Vojtech Vyklicky, Marek Ladislav, Ladislav Vyklicky

Front Pharmacol· November 2018

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Positive Modulators of the N-Methyl-d-aspartate Receptor: Structure-Activity Relationship Study of Steroidal 3-Hemiesters.
Barbora Krausova, Barbora Slavikova, Michaela Nekardova, Pavla Hubalkova, Vojtech Vyklicky, Ladislav Vyklicky

J Med Chem· May 2018

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Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit.
Vojtech Vyklicky, Barbora Krausova, Jiri Cerny, Marek Ladislav, Tereza Smejkalova, Ladislav Vyklicky

Front Mol Neurosci· April 2018

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Total Synthesis of ent-Pregnanolone Sulfate and Its Biological Investigation at the NMDA Receptor.
Vojtech Kapras, Vojtech Vyklicky, Milos Budesinsky, Ivana Cisarova, Ladislav Vyklicky

Org Lett· February 2018

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Physicochemical and biological properties of novel amide-based steroidal inhibitors of NMDA receptors.
Santosh Kumar Adla, Barbora Slavikova, Marketa Smidkova, Eva Tloustova, Martin Svoboda, Vojtech Vyklicky, Ladislav Vyklicky

Steroids· January 2017

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Neurosteroid-like Inhibitors of N-Methyl-d-aspartate Receptor: Substituted 2-Sulfates and 2-Hemisuccinates of Perhydrophenanthrene.
Barbora Slavikova, Hana Chodounska, Michaela Nekardova, Vojtech Vyklicky, Marek Ladislav, Ladislav Vyklicky

J Med Chem· May 2016

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Preferential Inhibition of Tonically over Phasically Activated NMDA Receptors by Pregnane Derivatives.
Vojtech Vyklicky, Tereza Smejkalova, Barbora Krausova, Ales Balik, Miloslav Korinek, Ladislav Vyklicky

J Neurosci· February 2016

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A New Class of Potent N-Methyl-D-Aspartate Receptor Inhibitors: Sulfated Neuroactive Steroids with Lipophilic D-Ring Modifications.
Eva Kudova, Hana Chodounska, Barbora Slavikova, Milos Budesinsky, Michaela Nekardova, Vojtech Vyklicky, Ladislav Vyklicky

J Med Chem· August 2015

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Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule.
Vojtech Vyklicky, Barbora Krausova, Jiri Cerny, Ales Balik, Martin Zapotocky, Ladislav Vyklicky

Sci Rep· June 2015

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Cholesterol modulates open probability and desensitization of NMDA receptors.
Miloslav Korinek, Vojtech Vyklicky, Jirina Borovska, Katarina Lichnerova, Martina Kaniakova, Ladislav Vyklicky

J Physiol· May 2015

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Neuroactive steroids with perfluorobenzoyl group.
Ivan Cerný, Miloš Buděšínský, Vladimír Pouzar, Vojtěch Vyklický, Barbora Krausová

Steroids· October 2012

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Key amino acid residues within the third membrane domains of NR1 and NR2 subunits contribute to the regulation of the surface delivery of N-methyl-D-aspartate receptors.
Martina Kaniakova, Barbora Krausova, Vojtech Vyklicky, Miloslav Korinek, Katarina Lichnerova, Ladislav Vyklicky

J Biol Chem· July 2012

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Access of inhibitory neurosteroids to the NMDA receptor.
Jirina Borovska, Vojtech Vyklicky, Eva Stastna, Vojtech Kapras, Barbora Slavikova, Ladislav Vyklicky

Br J Pharmacol· June 2012

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Neurosteroid modulation of N-methyl-D-aspartate receptors: molecular mechanism and behavioral effects.
Miloslav Korinek, Vojtech Kapras, Vojtech Vyklicky, Eva Adamusova, Jirina Borovska, Ladislav Vyklicky

Steroids· December 2011

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Azido analogs of neuroactive steroids.
Lukáš Vidrna, Ivan Černý, Vladimír Pouzar, Jiřina Borovská, Vojtěch Vyklický

Steroids· November 2011

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