Publications by authors named "Wan-Lin Lo"

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Age-dependent Zap70 expression in thymocytes regulates selection of the neonatal regulatory T cell repertoire.
Brian D Stadinski, Elizabeth A Mills, Preston A Humphries, Sarah B Cleveland, Parker Dow, Juan Carlos Zúñiga-Pflücker, Wan-Lin Lo

Nat Immunol· December 2025

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Publisher Correction: Intrinsically disordered domains expand the CAR T cell toolbox.
Tristan Yoder, Elizabeth A Mills, Wan-Lin Lo

Nat Chem Biol· November 2025

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Intrinsically disordered domains expand the CAR T cell toolbox.
Tristan Yoder, Elizabeth A Mills, Wan-Lin Lo

Nat Chem Biol· October 2025

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Aberrant T follicular helper cells generated by T17 cell plasticity in the gut promote extraintestinal autoimmunity.
Tingting Fan, Chi Tai, Kiah C Sleiman, Madeline P Cutcliffe, Haram Kim, Wan-Lin Lo, Randy Longman

Nat Immunol· May 2025

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The partitioning of TCR repertoires by thymic selection.
Wan-Lin Lo, Eric S Huseby

J Exp Med· October 2024

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A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection.
Miriam Bosch, Nina Kallin, Sainitin Donakonda, Jitao David Zhang, Hannah Wintersteller, Carlos Ramirez, Wan-Lin Lo, Souphalone Luangsay

Nature· July 2024

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The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain.
Anne E van Vlimmeren, Rashmi Voleti, Cassandra A Chartier, Ziyuan Jiang, Deepti Karandur, Wan-Lin Lo

Proc Natl Acad Sci U S A· July 2024

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The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain.
Anne E van Vlimmeren, Rashmi Voleti, Cassandra A Chartier, Ziyuan Jiang, Deepti Karandur, Wan-Lin Lo

bioRxiv· April 2024

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A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function.
Wan-Lin Lo, Miriam Kuhlmann, Gabrielle Rizzuto, H Atakan Ekiz, Elizabeth M Kolawole, Monica P Revelo

Nat Immunol· April 2023

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Two CTLA-4 ligands, separate pHates.
Preston A Humphries, Wan-Lin Lo

Nat Immunol· September 2022

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ZAP70, too little, too much can lead to autoimmunity.
Judith F Ashouri, Wan-Lin Lo, Trang T T Nguyen, Lin Shen, Arthur Weiss

Immunol Rev· May 2022

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Adapting T Cell Receptor Ligand Discrimination Capability LAT.
Wan-Lin Lo, Arthur Weiss

Front Immunol· October 2021

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DCision-making in tumors governs T cell anti-tumor immunity.
Francesca Alfei, Ping-Chih Ho, Wan-Lin Lo

Oncogene· August 2021

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Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads.
Enas Hallumi, Rose Shalah, Wan-Lin Lo, Jasmin Corso, Ilana Oz, Deborah Yablonski

J Immunol· May 2021

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How the T cell signaling network processes information to discriminate between self and agonist ligands.
Raman S Ganti, Wan-Lin Lo, Darren B McAffee, Jay T Groves, Arthur Weiss

Proc Natl Acad Sci U S A· October 2020

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Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination.
Wan-Lin Lo, Neel H Shah, Sara A Rubin, Weiguo Zhang, Veronika Horkova

Nat Immunol· November 2019

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CD45 functions as a signaling gatekeeper in T cells.
Adam H Courtney, Alexey A Shvets, Wen Lu, Gloria Griffante, Marianne Mollenauer, Wan-Lin Lo

Sci Signal· October 2019

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Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT.
Wan-Lin Lo, Neel H Shah, Nagib Ahsan, Veronika Horkova, Ondrej Stepanek, Arthur R Salomon

Nat Immunol· July 2018

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TCR Signaling: Mechanisms of Initiation and Propagation.
Adam H Courtney, Wan-Lin Lo, Arthur Weiss

Trends Biochem Sci· February 2018

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Loss of Navβ4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance.
Joseph L Ransdell, Edward Dranoff, Brandon Lau, Wan-Lin Lo, David L Donermeyer

Cell Rep· August 2017

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Loss of Navβ4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance.
Joseph L Ransdell, Edward Dranoff, Brandon Lau, Wan-Lin Lo, David L Donermeyer

Cell Rep· April 2017

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T cell immunodominance is dictated by the positively selecting self-peptide.
Wan-Lin Lo, Benjamin D Solomon, David L Donermeyer, Chyi-Song Hsieh, Paul M Allen

Elife· November 2015

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Self-peptides in TCR repertoire selection and peripheral T cell function.
Wan-Lin Lo, Paul M Allen

Curr Top Microbiol Immunol· July 2014

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Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC.
Stephen P Persaud, Chelsea R Parker, Wan-Lin Lo, K Scott Weber, Paul M Allen

Nat Immunol· March 2014

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Self-awareness: how self-peptide/MHC complexes are essential in the development of T cells.
Wan-Lin Lo, Paul M Allen

Mol Immunol· September 2013

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