Publications by authors named "Wayne L Backes"

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Environmentally persistent free radicals lead to selective inhibition of CYP1 monooxygenase activities, and increased production of reactive oxygen species by reaction uncoupling.
J Patrick Connick, Amari A Stepter, George F Cawley, Marilyn K Eyer, Wayne L Backes

Front Public Health· June 2025

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Environmentally persistent free radicals stimulate CYP2E1-mediated generation of reactive oxygen species at the expense of substrate metabolism.
George F Cawley, J Patrick Connick, Marilyn K Eyer, Wayne L Backes

Drug Metab Dispos· January 2025

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Identification of the N-terminal residues responsible for the differential microdomain localization of CYP1A1 and CYP1A2.
Robert M Fuchs, James R Reed, J Patrick Connick, Markéta Paloncýová, Martin Šrejber, Wayne L Backes

J Biol Chem· November 2024

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Functional characterization of CYP1 enzymes: Complex formation, membrane localization and function.
J Patrick Connick, James R Reed, George F Cawley, Aratrika Saha, Wayne L Backes

J Inorg Biochem· October 2023

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The Influence of Lipid Microdomain Heterogeneity on Protein-Protein Interactions: Proteomic Analysis of Co-Immunoprecipitated Binding Partners of P450 1A2 and P450 3A in Rat Liver Microsomes.
James R Reed, Jessie J Guidry, Marilyn Eyer, Wayne L Backes

Drug Metab Dispos· September 2023

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Proteomic and Bioinformatics Analysis of Membrane Lipid Domains after Brij 98 Solubilization of Uninduced and Phenobarbital-Induced Rat Liver Microsomes: Defining the Membrane Localization of the P450 Enzyme System.
James R Reed, Jessie J Guidry, Wayne L Backes

Drug Metab Dispos· April 2022

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Heme oxygenase-1 affects cytochrome P450 function through the formation of heteromeric complexes: Interactions between CYP1A2 and heme oxygenase-1.
J Patrick Connick, James R Reed, George F Cawley, Wayne L Backes

J Biol Chem· August 2021

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Identification of the contact region responsible for the formation of the homomeric CYP1A2•CYP1A2 complex.
Aratrika Saha, J Patrick Connick, James R Reed, Charles S Lott, Wayne L Backes

Biochem J· June 2021

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Heteromeric complex formation between human cytochrome P450 CYP1A1 and heme oxygenase-1.
J Patrick Connick, James R Reed, George F Cawley, Wayne L Backes

Biochem J· January 2021

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Particulate matter containing environmentally persistent free radicals induces AhR-dependent cytokine and reactive oxygen species production in human bronchial epithelial cells.
Ashlyn C Harmon, Valeria Y Hebert, Stephania A Cormier, Balamurugan Subramanian, James R Reed, Wayne L Backes

PLoS One· March 2019

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Characterization of Interactions Among CYP1A2, CYP2B4, and NADPH-cytochrome P450 Reductase: Identification of Specific Protein Complexes.
J Patrick Connick, James R Reed, Wayne L Backes

Drug Metab Dispos· March 2018

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Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function.
Amit V Pandey, Colin J Henderson, Yuji Ishii, Michel Kranendonk, Wayne L Backes

Front Pharmacol· November 2017

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Physical Studies of P450-P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures.
James R Reed, Wayne L Backes

Front Pharmacol· January 2017

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Cytochrome P450 Organization and Function Are Modulated by Endoplasmic Reticulum Phospholipid Heterogeneity.
Lauren M Brignac-Huber, Ji Won Park, James R Reed, Wayne L Backes

Drug Metab Dispos· December 2016

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The functional effects of physical interactions involving cytochromes P450: putative mechanisms of action and the extent of these effects in biological membranes.
James R Reed, Wayne L Backes

Drug Metab Rev· August 2016

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The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function.
Emily E Scott, C Roland Wolf, Michal Otyepka, Sara C Humphreys, James R Reed, Wayne L Backes

Drug Metab Dispos· April 2016

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Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2.
James R Reed, Albert Leo N dela Cruz, Slawo M Lomnicki, Wayne L Backes

Toxicol Appl Pharmacol· December 2015

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The Localization of Cytochrome P450s CYP1A1 and CYP1A2 into Different Lipid Microdomains Is Governed by Their N-terminal and Internal Protein Regions.
Ji Won Park, James R Reed, Wayne L Backes

J Biol Chem· December 2015

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Inhibition of cytochrome P450 2B4 by environmentally persistent free radical-containing particulate matter.
James R Reed, Albert Leo N dela Cruz, Slawo M Lomnicki, Wayne L Backes

Biochem Pharmacol· May 2015

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Cytochrome P450 system proteins reside in different regions of the endoplasmic reticulum.
Ji Won Park, James R Reed, Lauren M Brignac-Huber, Wayne L Backes

Biochem J· December 2014

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Environmentally persistent free radicals inhibit cytochrome P450 activity in rat liver microsomes.
James R Reed, George F Cawley, Taylor G Ardoin, Barry Dellinger, Slawomir M Lomnicki, Wayne L Backes

Toxicol Appl Pharmacol· June 2014

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Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges.
Eric F Johnson, J Patrick Connick, James R Reed, Wayne L Backes, Manoj C Desai

Drug Metab Dispos· January 2014

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Relationship between CYP1A2 localization and lipid microdomain formation as a function of lipid composition.
Lauren M Brignac-Huber, James R Reed, Marilyn K Eyer, Wayne L Backes

Drug Metab Dispos· November 2013

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Interactions between cytochromes P450 2B4 (CYP2B4) and 1A2 (CYP1A2) lead to alterations in toluene disposition and P450 uncoupling.
James R Reed, George F Cawley, Wayne L Backes

Biochemistry· June 2013

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Effect of homomeric P450-P450 complexes on P450 function.
James R Reed, J Patrick Connick, Dongmei Cheng, George F Cawley, Wayne L Backes

Biochem J· September 2012

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