Publications by authors named "Wayne W Poon"

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Interplay between CD33 and TREM2 in Alzheimer's Disease: Potential Mechanistic Insights into Microglial Function in Amyloid Pathology.
Elizabeth T Akinluyi, Kei Takahashi-Yamashiro, Meghan G Connolly, Wayne W Poon, Matthew S Macauley

ACS Chem Neurosci· December 2025

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Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.
Farid Rajabli, Penelope Benchek, Giuseppe Tosto, Nicholas Kushch, Jin Sha, Wayne W Poon

Genome Biol· July 2025

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Dissecting the Ability of Siglecs To Antagonize Fcγ Receptors.
Kelli A McCord, Chao Wang, Mirjam Anhalt, Wayne W Poon, Amanda L Gavin

ACS Cent Sci· February 2024

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Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies and nominates ancestry-specific loci , , and as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium.
Farid Rajabli, Penelope Benchek, Giuseppe Tosto, Nicholas Kushch, Jin Sha, Wayne W Poon

medRxiv· July 2023

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Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits.
Andrea M Reyes-Ortiz, Edsel M Abud, Mara S Burns, Jie Wu, Sarah J Hernandez, Wayne W Poon

iScience· January 2023

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Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.
Julia Tcw, Lu Qian, Nina H Pipalia, Michael J Chao, Shuang A Liang, Wayne W Poon

Cell· June 2022

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Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain.
Yang You, Satoshi Muraoka, Mark P Jedrychowski, Jianqiao Hu, Amanda K McQuade, Wayne W Poon

J Extracell Vesicles· January 2022

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Exosomal tau with seeding activity is released from Alzheimer's disease synapses, and seeding potential is associated with amyloid beta.
Emily Miyoshi, Tina Bilousova, Mikhail Melnik, Danyl Fakhrutdinov, Wayne W Poon

Lab Invest· December 2021

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α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy.
Suman Dutta, Simon Hornung, Adira Kruayatidee, Katherine N Maina, Irish Del Rosario, Wayne W Poon

Acta Neuropathol· September 2021

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Correction to: α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy.
Suman Dutta, Simon Hornung, Adira Kruayatidee, Katherine N Maina, Irish Del Rosario, Wayne W Poon

Acta Neuropathol· September 2021

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Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes.
Gloriia Novikova, Manav Kapoor, Julia Tcw, Edsel M Abud, Anastasia G Efthymiou, Wayne W Poon

Nat Commun· March 2021

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Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
Brian W Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C Bis, Vincent Damotte, Wayne W Poon

Nat Genet· September 2019

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Apolipoprotein E/Amyloid-β Complex Accumulates in Alzheimer Disease Cortical Synapses via Apolipoprotein E Receptors and Is Enhanced by APOE4.
Tina Bilousova, Mikhail Melnik, Emily Miyoshi, Bianca L Gonzalez, Wayne W Poon

Am J Pathol· August 2019

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Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
Brian W Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C Bis, Vincent Damotte, Wayne W Poon

Nat Genet· March 2019

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Analysis of shared heritability in common disorders of the brain.

Science· June 2018

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Cerebrovascular pathology in Down syndrome and Alzheimer disease.
Elizabeth Head, Michael J Phelan, Eric Doran, Ronald C Kim, Wayne W Poon

Acta Neuropathol Commun· December 2017

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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
Rebecca Sims, Sven J van der Lee, Adam C Naj, Céline Bellenguez, Nandini Badarinarayan, Wayne W Poon

Nat Genet· September 2017

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Tau Spread, Apolipoprotein E, Inflammation, and More: Rapidly Evolving Basic Science in Alzheimer Disease.
Bianca Gonzalez, Edsel M Abud, Abigail M Abud, Wayne W Poon, Karen H Gylys

Neurol Clin· May 2017

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iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.
Edsel M Abud, Ricardo N Ramirez, Eric S Martinez, Luke M Healy, Cecilia H H Nguyen, Wayne W Poon

Neuron· April 2017

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Nuclear uptake of an amino-terminal fragment of apolipoprotein E4 promotes cell death and localizes within microglia of the Alzheimer's disease brain.
Julia E Love, Ryan J Day, Justin W Gause, Raquel J Brown, Xinzhu Pu, Wayne W Poon

Int J Physiol Pathophysiol Pharmacol· April 2017

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HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer's Disease.
Samuel E Marsh, Stephen T Yeung, Maria Torres, Lydia Lau, Joy L Davis, Wayne W Poon

Stem Cell Reports· February 2017

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Increased tauopathy drives microglia-mediated clearance of beta-amyloid.
Wesley Chen, Edsel A Abud, Stephen T Yeung, Anita Lakatos, Trevor Nassi, Wayne W Poon

Acta Neuropathol Commun· June 2016

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The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function.
Samuel E Marsh, Edsel M Abud, Anita Lakatos, Alborz Karimzadeh, Stephen T Yeung, Wayne W Poon

Proc Natl Acad Sci U S A· March 2016

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Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases.
Tina Bilousova, Carol A Miller, Wayne W Poon, Harry V Vinters, Maria Corrada

Am J Pathol· January 2016

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Altered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease.
Liang Zhang, Sergey Trushin, Trace A Christensen, Benjamin V Bachmeier, Benjamin Gateno, Wayne W Poon

Sci Rep· January 2016

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