Publications by authors named "Webster Santos"

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Replication stress increases de novo CNVs across the malaria parasite genome.
Noah Brown, Aleksander Luniewski, Xuanxuan Yu, Michelle Warthan, Shiwei Liu, Webster Santos

bioRxiv· September 2025

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Diverse actions of 15 structurally unrelated mitochondrial uncouplers in cells and mice.
Divya P Shah, Calum S Vancuylenburg, Ellen M Olzomer, Sing-Young Chen, Robert J Grams, Webster L Santos

Mol Metab· September 2025

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Direct long-read visualization reveals hidden variation in GCH1 gene copy number and precise expansion steps.
Shiwei Liu, Julia Zulawinska, Emily R Ebel, Aleksander Luniewski, Charles Danis, Webster Santos

BMC Genomics· July 2025

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Structure-activity relationship study of benserazide derivatives as PilB inhibitors.
Joseph E Quinlan, Ghazal Soleymani, Tori M Shimozono, Zhaomin Yang, Webster L Santos

RSC Adv· June 2025

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Assessment of Spinster homologue 2 (Spns2)-dependent transport of sphingosine-1-phosphate as a therapeutic target.
Yugesh Kharel, Tao Huang, Kyle Dunnavant, Daniel Foster, George M P R Souza, Webster L Santos

Br J Pharmacol· May 2025

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Unsymmetric hydroxylamine and hydrazine BAM15 derivatives as potent mitochondrial uncouplers.
Joseph E Quinlan, Joseph M Salamoun, Christopher J Garcia, Stefan Hargett, Martina Beretta, Webster L Santos

Bioorg Med Chem· February 2025

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Design, synthesis, and biological evaluation of imidazo[4,5-b]pyridine mitochondrial uncouplers for the treatment of metabolic dysfunction-associated steatohepatitis (MASH).
Joseph M Salamoun, Emily L Krinos, Mary A Foutz, Stefan R Hargett, Martina Beretta, Webster L Santos

Eur J Med Chem· December 2024

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Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4-]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis.
Mary A Foutz, Emily L Krinos, Martina Beretta, Stefan R Hargett, Riya Shrestha, Webster L Santos

J Med Chem· December 2024

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Design, synthesis and biological evaluation of glucose metabolism inhibitors as anticancer agents.
Yao Cheng, John Patrick Jones, Tsz Tin Yu, Ellen M Olzomer, Jacky Su, Webster L Santos

Bioorg Chem· October 2024

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Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca channel.
Dragos Andrei Duse, Nathalie Hannelore Schröder, Tanu Srivastava, Marcel Benkhoff, Jens Vogt, Webster Santos

Basic Res Cardiol· October 2024

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Beneficial effects of MGL-3196 and BAM15 combination in a mouse model of fatty liver disease.
Mingyan Zhou, Catherine Li, Frances L Byrne, Calum S Vancuylenburg, Ellen M Olzomer, Webster L Santos

Acta Physiol (Oxf)· October 2024

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Corrigendum to "Design, synthesis and biological evaluation of glucose metabolism inhibitors as anticancer agents" [Bioorg. Chem. 151 (2024) 107665].
Yao Cheng, John Patrick Jones, Tsz Tin Yu, Ellen M Olzomer, Jacky Su, Webster L Santos

Bioorg Chem· October 2024

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Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors.
Daniel J Foster, Kyle Dunnavant, Christopher W Shrader, Marion LoPresti, Sarah Seay, Webster L Santos

J Med Chem· July 2024

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Chemo-, Regio-, and Stereoselective -Hydroboration of 1,3-Enynes: Copper-Catalyzed Access to ()- and ()-2-Boryl-1,3-dienes.
Nicklas W Buchbinder, Long H Nguyen, Owen N Beck, Andrew D Bage, Carla Slebodnick, Webster L Santos

Org Lett· July 2024

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Phosphine-Catalyzed 1,2-cis-Diboration of 1,3-Butadiynes.
Weipeng Li, Robert Ricker, Ka Lok Chan, Pak Fung Lau, Nicklas W Buchbinder, Webster L Santos

Chemistry· June 2024

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Correction to "The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology".
R Justin Grams, Webster L Santos, Ion Romulus Scorei, Antonio Abad-García, Carol Ann Rosenblum

Chem Rev· June 2024

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Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice.
Martina Beretta, Yumin Dai, Ellen M Olzomer, Calum S Vancuylenburg, José A Santiago-Rivera, Webster L Santos

Diabetes· March 2024

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The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology.
R Justin Grams, Webster L Santos, Ion Romulus Scorei, Antonio Abad-García, Carol Ann Rosenblum

Chem Rev· March 2024

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Design, Synthesis, and Antifungal Activity of 3-Substituted-2()-Oxaboroles.
Rose Campbell, Nicklas W Buchbinder, Connor Szwetkowski, Yumeng Zhu, Karla Piedl, Webster L Santos

ACS Med Chem Lett· March 2024

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Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice.
Sing-Young Chen, Aiden J Telfser, Ellen M Olzomer, Calum S Vancuylenberg, Mingyan Zhou, Webster L Santos

Clin Sci (Lond)· February 2024

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Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice.
Sing-Young Chen, Martina Beretta, Ellen M Olzomer, Stephanie J Alexopoulos, Divya P Shah, Webster L Santos

Biochim Biophys Acta Mol Basis Dis· January 2024

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Correction: Mechanism of sphingosine 1-phosphate clearance from blood.
Yugesh Kharel, Tao Huang, Anita Salamon, Thurl E Harris, Webster L Santos

Biochem J· December 2023

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Imidazole-based sphingosine-1-phosphate transporter Spns2 inhibitors.
Christopher W Shrader, Daniel Foster, Yugesh Kharel, Tao Huang, Kevin R Lynch, Webster L Santos

Bioorg Med Chem Lett· November 2023

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Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors.
Yugesh Kharel, Tao Huang, Webster L Santos, Kevin R Lynch

SLAS Discov· September 2023

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Regio- and Stereoselective Copper-Catalyzed Borylation-Protodeboronation of 1,3-Diynes: Access to ()-1,3-Enynes.
Ariel L Burgio, Nicklas W Buchbinder, Webster L Santos

Org Lett· April 2023

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