Publications by authors named "Wei Jen Tang"

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Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity.
Jordan M Mancl, Wenguang G Liang, Nicholas L Bayhi, Hui Wei, William Budell, Wei-Jen Tang

bioRxiv· December 2025

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Dimerization and dynamics of human angiotensin-I converting enzyme revealed by cryo-EM and MD simulations.
Jordan M Mancl, Xiaoyang Wu, Minglei Zhao, Wei-Jen Tang

Elife· September 2025

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Dimerization and dynamics of angiotensin-I converting enzyme revealed by cryo-EM and MD simulations.
Jordan M Mancl, Xiaoyang Wu, Minglei Zhao, Wei-Jen Tang

bioRxiv· July 2025

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Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
Wenguang G Liang, Juwina Wijaya, Hui Wei, Alex J Noble, Jordan M Mancl, Wei-Jen Tang

Nat Commun· April 2022

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Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states.
Wenguang G Liang, Jordan M Mancl, Minglei Zhao, Wei-Jen Tang

Structure· July 2021

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Degradation of Alzheimer's Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme.
Bikash R Sahoo, Pritam Kumar Panda, Wenguang Liang, Wei-Jen Tang, Rajeev Ahuja

J Mol Biol· June 2021

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exoenzyme Y directly bundles actin filaments.
Jordan M Mancl, Cristian Suarez, Wenguang G Liang, David R Kovar, Wei-Jen Tang

J Biol Chem· March 2020

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Reinvestigating the synthesis and efficacy of small benzimidazole derivatives as presequence protease enhancers.
Nan-Sheng Li, Wenguang Liang, Joseph A Piccirilli, Wei-Jen Tang

Eur J Med Chem· December 2019

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Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening.
Florence Leroux, Damien Bosc, Terence Beghyn, Paul Hermant, Sandrine Warenghem, Wei-Jen Tang

Eur J Med Chem· October 2019

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Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin.
Mara Farcasanu, Andrew G Wang, Tomasz Uchański, Lucas J Bailey, Jiping Yue, Wei-Jen Tang

Biochemistry· July 2019

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Catalytic Mechanism of Amyloid-β Peptide Degradation by Insulin Degrading Enzyme: Insights from Quantum Mechanics and Molecular Mechanics Style Møller-Plesset Second Order Perturbation Theory Calculation.
Rui Lai, Wei-Jen Tang, Hui Li

J Chem Inf Model· September 2018

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Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Zhening Zhang, Wenguang G Liang, Lucas J Bailey, Yong Zi Tan, Hui Wei, Wei-Jen Tang

Elife· March 2018

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Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
Lucas J Bailey, Kimberly M Sheehy, Pawel K Dominik, Wenguang G Liang, Huan Rui, Wei-Jen Tang

J Mol Biol· February 2018

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Erratum: ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics.
Yanlei Ma, Jiping Yue, Yao Zhang, Chenzhang Shi, Matt Odenwald, Wei-Jen Tang

Nat Commun· July 2017

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ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics.
Yanlei Ma, Jiping Yue, Yao Zhang, Chenzhang Shi, Matt Odenwald, Wei-Jen Tang

Nat Commun· May 2017

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Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL.
Shruti Sharma, Natalie Galanina, Ailin Guo, Jimmy Lee, Sabah Kadri, Wei-Jen Tang

Oncotarget· October 2016

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Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Wenguang G Liang, Catherine G Triandafillou, Teng-Yi Huang, Medel Manuel L Zulueta, Shiladitya Banerjee, Wei-Jen Tang

Proc Natl Acad Sci U S A· May 2016

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In vivo epidermal migration requires focal adhesion targeting of ACF7.
Jiping Yue, Yao Zhang, Wenguang G Liang, Xuewen Gou, Philbert Lee, Wei-Jen Tang

Nat Commun· May 2016

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Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus.
Wei-Jen Tang

Trends Endocrinol Metab· January 2016

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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Rebecca Deprez-Poulain, Nathalie Hennuyer, Damien Bosc, Wenguang G Liang, Emmanuelle Enée, Wei-Jen Tang

Nat Commun· September 2015

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Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor.
Carolin Lübker, Stefan Dove, Wei-Jen Tang, Ramona J Bieber Urbauer, Jackob Moskovitz

Toxins (Basel)· July 2015

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Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
Wenguang G Liang, Min Ren, Fan Zhao, Wei-Jen Tang

J Mol Biol· March 2015

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Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.
Julie Charton, Marion Gauriot, Jane Totobenazara, Nathalie Hennuyer, Julie Dumont, Wei-Jen Tang

Eur J Med Chem· January 2015

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Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation.
Miho Tanaka-Matakatsu, John Miller, Daniel Borger, Wei-Jen Tang, Wei Du

Dev Biol· August 2014

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Molecular basis of substrate recognition and degradation by human presequence protease.
John V King, Wenguang G Liang, Kathryn P Scherpelz, Alexander B Schilling, Stephen C Meredith, Wei-Jen Tang

Structure· July 2014

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