Publications by authors named "Julie Charton"

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A new chemotype that opens the S2∗ pocket of the 3CL protease exhibits antiviral activity against SARS-CoV-2.
Laura Mourot, Fatima-Zahra Chaibi, Nour Bou-Karroum, Paul Carré, Alberto Abengozar Munoz, Julie Charton

Eur J Med Chem· January 2026

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N-acylbenzimidazoles as selective Acylators of the catalytic cystein of the coronavirus 3CL protease.
Fatima-Zahra Chaibi, Lucile Brier, Paul Carré, Valérie Landry, Lowiese Desmarets, Julie Charton

Eur J Med Chem· October 2024

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Identification of new correctors for traffic-defective ABCB4 variants by a high-content screening approach.
Mounia Lakli, Julie Dumont, Virginie Vauthier, Julie Charton, Veronica Crespi

Commun Biol· July 2024

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Capillary electrokinetic chromatography for chiral separation of potential SARS-CoV-2 3CL protease inhibitors.
Lucile Brier, Christophe Furman, Julie Charton, Benoit Deprez, Emmanuelle Lipka

Electrophoresis· June 2024

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Discovery, Structure-Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5.
Sylvain Picon, Rajaa Boulahjar, Vanessa Hoguet, Morgane Baron, Isabelle Duplan, Julie Charton

J Med Chem· September 2023

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Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses.
Lucile Brier, Haitham Hassan, Xavier Hanoulle, Valerie Landry, Danai Moschidi, Julie Charton

Eur J Med Chem· March 2023

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Identification of indole-based activators of insulin degrading enzyme.
Nicolas Kraupner, Chau Phi Dinh, Xiaoan Wen, Valérie Landry, Adrien Herledan, Julie Charton

Eur J Med Chem· January 2022

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Farnesoid X Receptor Activation in Brain Alters Brown Adipose Tissue Function via the Sympathetic System.
Benjamin Deckmyn, Dorothée Domenger, Chloé Blondel, Sarah Ducastel, Emilie Nicolas, Julie Charton

Front Mol Neurosci· January 2022

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NMR Spectroscopy of the Main Protease of SARS-CoV-2 and Fragment-Based Screening Identify Three Protein Hotspots and an Antiviral Fragment.
François-Xavier Cantrelle, Emmanuelle Boll, Lucile Brier, Danai Moschidi, Sandrine Belouzard, Julie Charton

Angew Chem Int Ed Engl· November 2021

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Molecular Design in Practice: A Review of Selected Projects in a French Research Institute That Illustrates the Link between Chemical Biology and Medicinal Chemistry.
Benoit Deprez, Damien Bosc, Julie Charton, Cyril Couturier, Rebecca Deprez-Poulain

Molecules· October 2021

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Electrophoretic separation of multiple chiral center analyte with a three cyclodextrins mixture.
Zuo La, Cécile Danel, Gaëlle Grolaux, Julie Charton, Christophe Furman

Electrophoresis· September 2021

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Supercritical fluid chromatography and liquid chromatography for isomeric separation of a multiple chiral centers analyte.
Zuo La, Julie Charton, Lucile Etienne, Julie Bourey, Emmanuelle Lipka

J Chromatogr A· August 2021

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Hypothalamic bile acid-TGR5 signaling protects from obesity.
Ashley Castellanos-Jankiewicz, Omar Guzmán-Quevedo, Valérie S Fénelon, Philippe Zizzari, Carmelo Quarta, Julie Charton

Cell Metab· July 2021

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Modulators of hERAP2 discovered by high-throughput screening.
Medve Laura, Gealageas Ronan, Lam Bao Vy, Guillaume Valentin, Castillo-Aguilera Omar, Charton Julie

Eur J Med Chem· February 2021

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Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor.
Vanessa Hoguet, Manuel Lasalle, Mathieu Maingot, Geoffroy Dequirez, Rajaa Boulahjar, Julie Charton

J Med Chem· February 2021

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Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening.
Florence Leroux, Damien Bosc, Terence Beghyn, Paul Hermant, Sandrine Warenghem, Julie Charton

Eur J Med Chem· October 2019

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Application of tandem coupling of columns in supercritical fluid chromatography for stereoisomeric separation: Optimization and simulation.
Abdeljalil Akchich, Julie Charton, Emmanuelle Lipka

J Chromatogr A· March 2019

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Supercritical fluid chromatography versus high performance liquid chromatography for enantiomeric and diastereoisomeric separations on coated polysaccharides-based stationary phases: Application to dihydropyridone derivatives.
Vanessa Hoguet, Julie Charton, Paul-Emile Hecquet, Chahinaze Lakhmi, Emmanuelle Lipka

J Chromatogr A· May 2018

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Single and dual cyclodextrins systems for the enantiomeric and diastereoisomeric separations of structurally related dihydropyridone analogues.
Thibaut Delplanques, Rajaa Boulahjar, Julie Charton, Corentin Houze, Michael Howsam

Electrophoresis· August 2017

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Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance.
Manuel Lasalle, Vanessa Hoguet, Nathalie Hennuyer, Florence Leroux, Catherine Piveteau, Julie Charton

J Med Chem· May 2017

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Characterization of monoclonal antibodies by a fast and easy liquid chromatography-mass spectrometry time-of-flight analysis on culture supernatant.
Antoine Henninot, Aurelie Terrier, Julie Charton, Rémi Urbain, Alexandre Fontayne

Anal Biochem· December 2015

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The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity.
Evie P M Broeders, Emmani B M Nascimento, Bas Havekes, Boudewijn Brans, Kay H M Roumans, Julie Charton

Cell Metab· September 2015

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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Rebecca Deprez-Poulain, Nathalie Hennuyer, Damien Bosc, Wenguang G Liang, Emmanuelle Enée, Julie Charton

Nat Commun· September 2015

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Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.
Julie Charton, Marion Gauriot, Jane Totobenazara, Nathalie Hennuyer, Julie Dumont

Eur J Med Chem· January 2015

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Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis.
Julie Charton, Marion Gauriot, Qing Guo, Nathalie Hennuyer, Xavier Marechal

Eur J Med Chem· May 2014

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