Publications by authors named "Weikai Ge"

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In vivo evaluation of guide-free Cas9-induced safety risks in a pig model.
Weikai Ge, Shixue Gou, Xiaozhu Zhao, Qin Jin, Zhenpeng Zhuang

Signal Transduct Target Ther· July 2024

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Evaluation of guide-free Cas9-induced genomic damage and transcriptome changes in pig embryos.
Weikai Ge, Xiaozhu Zhao, Shixue Gou, Qin Jin, Fangbing Chen

Mol Ther Nucleic Acids· December 2023

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Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation.
Qin Jin, Xiaoyi Liu, Zhenpeng Zhuang, Jiayuan Huang, Shixue Gou, Weikai Ge

Genome Biol· January 2023

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Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression.
Qin Jin, Xiaoyu Yang, Shixue Gou, Xiaoyi Liu, Zhenpeng Zhuang, Weikai Ge

Sci China Life Sci· November 2022

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AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns.
Yanhui Liang, Jingke Xie, Quanjun Zhang, Xiaomin Wang, Shixue Gou, Weikai Ge

Nucleic Acids Res· May 2022

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Correction: Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses.
Wenjing Li, Lei Shi, Zhenpeng Zhuang, Han Wu, Meng Lian, Weikai Ge

J Immunol· November 2021

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CRISPR/Cas9-Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I.
Nan Li, Shixue Gou, Jiaowei Wang, Quanjun Zhang, Xingyun Huang, Weikai Ge

Mol Ther· March 2021

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Improving the Cpf1-mediated base editing system by combining dCas9/dead sgRNA with human APOBEC3A variants.
Meng Lian, Fangbing Chen, Xingyun Huang, Xiaozhu Zhao, Shixue Gou, Weikai Ge

J Genet Genomics· January 2021

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Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses.
Wenjing Li, Lei Shi, Zhenpeng Zhuang, Han Wu, Meng Lian, Weikai Ge

J Immunol· November 2020

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ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems.
Jingke Xie, Xingyun Huang, Xia Wang, Shixue Gou, Yanhui Liang, Weikai Ge

BMC Biol· September 2020

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Efficient base editing for multiple genes and loci in pigs using base editors.
Jingke Xie, Weikai Ge, Nan Li, Qishuai Liu, Fangbing Chen

Nat Commun· June 2019

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Engineering CRISPR/Cpf1 with tRNA promotes genome editing capability in mammalian systems.
Han Wu, Qishuai Liu, Hui Shi, Jingke Xie, Quanjun Zhang, Weikai Ge

Cell Mol Life Sci· October 2018

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XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer.
Degong Ruan, Jiangyun Peng, Xiaoshan Wang, Zhen Ouyang, Qingjian Zou, Weikai Ge

Stem Cell Reports· February 2018

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