Publications by authors named "Wenle Yang"

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Rational two-round modification for developing isopeptide bond-containing antimicrobial peptide with enhanced stability and potent activity against multidrug-resistant gram-negative bacteria.
Tiantian Yan, Yue Jia, Ruoyan Jiao, Xinyu Cai, Fang Li, Weili Yang, Wenle Yang

Biochem Pharmacol· December 2025

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Correction: Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFR.
Xiao-Wei Zhang, Lin Li, Wen-Qian Hu, Ming-Ning Hu, Yan Tao, Wen-Le Yang

Cell Death Dis· November 2025

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Halogenated Sulfono-γ-AApeptides Modified Cationic AMPs Have Enhanced Stability and Therapeutic Potential against Clinically Important MDR Infections.
Xiaomin Guo, Yingying An, Tiantian Yan, Yue Jia, Ruoyan Jiao, Weili Yang, Wenle Yang

ACS Infect Dis· July 2025

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Iterative Optimization Yields Stapled Peptides with Superior Pharmacokinetics and Potency for Renal Fibrosis Treatment.
Bochuan Deng, Ping Su, Lu Cheng, Jiao Zhang, Xiang Zhang, Wenle Yang

J Med Chem· April 2025

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The novel peptide PEP-Z-2 potentially treats renal fibrosis in vivo and in vitro by regulating TGF-β/Smad/AKT/MAPK signaling.
Xiaocui Feng, Jianfeng Zhang, Runling Yang, Hong Lei, Wanru Chen, Wenle Yang

Eur J Pharmacol· November 2024

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Enhancing the stability and therapeutic potential of the antimicrobial peptide Feleucin-K3 against Multidrug-Resistant a. Baumannii through rational utilization of a D-amino acid substitution strategy.
Yingying An, Xiaomin Guo, Tiantian Yan, Yue Jia, Ruoyan Jiao, Wenle Yang

Biochem Pharmacol· July 2024

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Novel Peptide DR3penA as a Low-Toxicity Antirenal Fibrosis Agent by Suppressing the TGF-β1/miR-212-5p/Low-Density Lipoprotein Receptor Class a Domain Containing 4/Smad Axis.
Bochuan Deng, Jiao Zhang, Xiang Zhang, Dan Wang, Lu Cheng, Wenle Yang

ACS Pharmacol Transl Sci· April 2024

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Novel antimicrobial peptides modified with fluorinated sulfono-γ-AA having high stability and targeting multidrug-resistant bacteria infections.
Xiaomin Guo, Xiaokang Miao, Yingying An, Tiantian Yan, Yue Jia, Wenle Yang

Eur J Med Chem· January 2024

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The Peptide DH-(4-pentenyl)-ANPQIR-NH Exhibits Antifibrotic Activity in Multiple Pulmonary Fibrosis Models Induced by Particulate and Soluble Chemical Fibrogenic Agents.
Jieru Li, Bochuan Deng, Jiao Zhang, Xiang Zhang, Lu Cheng, Wenle Yang

J Pharmacol Exp Ther· January 2024

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The novel peptide DR4penA attenuates the bleomycin- and paraquat-induced pulmonary fibrosis by suppressing the TGF-β/Smad signaling pathway.
Dan Wang, Bochuan Deng, Lu Cheng, Jieru Li, Xiaomin Guo, Wenle Yang

FASEB J· November 2023

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Neurokinin-1 receptor drives PKCɑ-AURKA/N-Myc signaling to facilitate the neuroendocrine progression of prostate cancer.
Xiao-Wei Zhang, Jing-Yi Li, Lin Li, Wen-Qian Hu, Yan Tao, Wen-Le Yang

Cell Death Dis· June 2023

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A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis.
Dan Wang, Bochuan Deng, Lu Cheng, Jieru Li, Jiao Zhang, Wenle Yang

Acta Pharm Sin B· February 2023

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Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFR.
Xiao-Wei Zhang, Lin Li, Wen-Qian Hu, Ming-Ning Hu, Yan Tao, Wen-Le Yang

Cell Death Dis· January 2022

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Inhibition of autophagy by YC-1 promotes gefitinib induced apoptosis by targeting FOXO1 in gefitinib-resistant NSCLC cells.
Hui Hu, Xiao-Wei Zhang, Lin Li, Ming-Ning Hu, Wen-Qian Hu, Wen-Le Yang

Eur J Pharmacol· October 2021

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Potent Antimicrobial and Antibiofilm Activities of Feleucin-K3 Analogs Modified by α-(4-Pentenyl)-Ala against Multidrug-Resistant Bacteria.
Xiaomin Guo, Tiantian Yan, Jing Rao, Xin Yue, Xiong Pei, Wenle Yang

Biomolecules· May 2021

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Feleucin-K3 Analogue with an α-(4-Pentenyl)-Ala Substitution at the Key Site Has More Potent Antimicrobial and Antibiofilm Activities and .
Xiaomin Guo, Jing Rao, Tiantian Yan, Bangzhi Zhang, Wenle Yang

ACS Infect Dis· January 2021

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The antimicrobial peptide YD attenuates inflammation miR-155 targeting CASP12 during liver fibrosis.
Zhibin Yan, Dan Wang, Chunmei An, Hongjiao Xu, Qian Zhao, Wenle Yang

Acta Pharm Sin B· January 2021

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Apoptosis as an underlying mechanism in lymphocytes induced by riboflavin and ultraviolet light.
Hailiang Hu, Fei Xu, Wenle Yang, Jun Ren, Weihao Ge, Peng Yang

Transfus Apher Sci· December 2020

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Peptide DR8 suppresses epithelial-to-mesenchymal transition via the TGF-β/MAPK signaling pathway in renal fibrosis.
Bochuan Deng, Wenle Yang, Dan Wang, Lu Cheng, Lili Bu

Life Sci· November 2020

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CPF-C1 analog with effective antimicrobial and antibiofilm activities against Staphylococcus aureus including MRSA.
Junqiu Xie, Yao Li, Xiaomin Guo, Jing Rao, Tiantian Yan, Wenle Yang

Biochimie· September 2020

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YC-1 potentiates the antitumor activity of gefitinib by inhibiting HIF-1α and promoting the endocytic trafficking and degradation of EGFR in gefitinib-resistant non-small-cell lung cancer cells.
Hui Hu, Xiao-Kang Miao, Jing-Yi Li, Xiao-Wei Zhang, Jing-Jie Xu, Wen-Le Yang

Eur J Pharmacol· May 2020

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Enhanced cell selectivity of hybrid peptides with potential antimicrobial activity and immunomodulatory effect.
Xiaokang Miao, Tianxiong Zhou, Jingying Zhang, Jingjie Xu, Xiaomin Guo, Wenle Yang

Biochim Biophys Acta Gen Subj· April 2020

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Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-κB signaling pathways in diabetic nephropathy.
Mingyan Zhang, Zhibin Yan, Lili Bu, Chunmei An, Dan Wang, Wenle Yang

Drug Des Devel Ther· October 2018

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Potent effects of amino acid scanned antimicrobial peptide Feleucin-K3 analogs against both multidrug-resistant strains and biofilms of Pseudomonas aeruginosa.
Junqiu Xie, Yao Li, Jing Li, Zhibin Yan, Dan Wang, Wenle Yang

Amino Acids· October 2018

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Novel antimicrobial peptide CPF-C1 analogs with superior stabilities and activities against multidrug-resistant bacteria.
Junqiu Xie, Qian Zhao, Sisi Li, Zhibin Yan, Jing Li, Wenle Yang

Chem Biol Drug Des· November 2017

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