Publications by authors named "Willard Lew"

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Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Thorsten A Kirschberg, Sammy Metobo, Michael O Clarke, Vangelis Aktoudianakis, Darius Babusis, Willard Lew

Bioorg Med Chem Lett· April 2017

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Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.
Dustin Siegel, Hon C Hui, Edward Doerffler, Michael O Clarke, Kwon Chun, Willard Lew

J Med Chem· March 2017

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Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.
Travis K Warren, Robert Jordan, Michael K Lo, Adrian S Ray, Richard L Mackman, Willard Lew

Nature· March 2016

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Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.
Aesop Cho, Lijun Zhang, Jie Xu, Rick Lee, Thomas Butler, Willard Lew

J Med Chem· March 2014

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Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection.
Scott E Lazerwith, Willard Lew, Jennifer Zhang, Philip Morganelli, Qi Liu

J Med Chem· March 2014

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Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase.
Martijn Fenaux, Stacey Eng, Stephanie A Leavitt, Yu-Jen Lee, Eric M Mabery, Willard Lew

Antimicrob Agents Chemother· February 2013

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2-Aminobenzimidazoles as potent Aurora kinase inhibitors.
Min Zhong, Minna Bui, Wang Shen, Subramanian Baskaran, Darin A Allen, Willard Lew

Bioorg Med Chem Lett· September 2009

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Water-soluble prodrugs of an Aurora kinase inhibitor.
Johan D Oslob, Stacey A Heumann, Chul H Yu, Darin A Allen, Subramanian Baskaran, Willard Lew

Bioorg Med Chem Lett· March 2009

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Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors.
Emily J Hanan, Raymond V Fucini, Michael J Romanowski, Robert A Elling, Willard Lew

Bioorg Med Chem Lett· October 2008

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Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Raymond V Fucini, Emily J Hanan, Michael J Romanowski, Robert A Elling, Willard Lew

Bioorg Med Chem Lett· October 2008

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Discovery of a potent and selective aurora kinase inhibitor.
Johan D Oslob, Michael J Romanowski, Darin A Allen, Subramanian Baskaran, Minna Bui, Willard Lew

Bioorg Med Chem Lett· September 2008

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Identification of potent and novel small-molecule inhibitors of caspase-3.
Darin A Allen, Phuongly Pham, Ingrid C Choong, Bruce Fahr, Matthew T Burdett, Willard Lew

Bioorg Med Chem Lett· November 2003

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Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design.
Ingrid C Choong, Willard Lew, Dennis Lee, Phuongly Pham, Matthew T Burdett

J Med Chem· November 2002

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