Publications by authors named "William Astle"

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Protocol for genetic discovery and fine-mapping of multivariate latent factors from high-dimensional traits.
William J Astle, Adam S Butterworth, Jennifer L Asimit

STAR Protoc· November 2025

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Improved genetic discovery and fine-mapping resolution through multivariate latent factor analysis of high-dimensional traits.
Feng Zhou, William J Astle, Adam S Butterworth, Jennifer L Asimit

Cell Genom· May 2025

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A signature of platelet reactivity in CBC scattergrams reveals genetic predictors of thrombotic disease risk.
Hippolyte Verdier, Patrick Thomas, Joana Batista, Carly Kempster, Harriet McKinney, William J Astle

Blood· November 2023

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Preliminary Results of New Modification of Vertical Muscle Transposition to Enhance Abducting Force in Sixth Nerve Palsy.
Santa Heede, William Astle, Emi Sanders, Irina Kovalevskaya, Sandra Valeina

Biomed Hub· October 2023

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A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.
Parsa Akbari, Dragana Vuckovic, Luca Stefanucci, Tao Jiang, Kousik Kundu, William J Astle

Nat Commun· August 2023

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Incidence of Glaucoma-Related Adverse Events in the First 5 Years After Pediatric Lensectomy.
Erick D Bothun, Michael X Repka, Raymond T Kraker, Rui Wu, David A Leske, William F Astle

JAMA Ophthalmol· April 2023

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Genetic regulation of fetal hemoglobin across global populations.
Liam D Cato, Rick Li, Henry Y Lu, Fulong Yu, Mariel Wissman, William J Astle

medRxiv· March 2023

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On randomized sketching algorithms and the Tracy-Widom law.
Daniel Ahfock, William J Astle, Sylvia Richardson

Stat Comput· January 2023

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Reactive infectious mucocutaneous eruption - repeat etanercept after intravenous immunoglobulin: A case report.
Rochelle Tonkin, Malika Ladha, Nicole Johnson, William F Astle, Ami Britton

SAGE Open Med Case Rep· August 2022

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G protein-coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1.
Kate Downes, Xuefei Zhao, Nicholas S Gleadall, Harriet McKinney, Carly Kempster, William J Astle

Blood Adv· April 2022

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Advances in understanding the pathogenesis of hereditary macrothrombocytopenia.
Janine Collins, William J Astle, Karyn Megy, Andrew D Mumford, Dragana Vuckovic

Br J Haematol· October 2021

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Familial pseudohyperkalemia induces significantly higher levels of extracellular potassium in early storage of red cell concentrates without affecting other standard measures of quality: A case control and allele frequency study.
Athinoula Meli, Margaret McAndrew, Amy Frary, Karola Rehnstrom, Christian J Stevens-Hernandez, William Astle

Transfusion· August 2021

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A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis.
Steven Bell, Andreas S Rigas, Magnus K Magnusson, Egil Ferkingstad, Elias Allara, William J Astle

Commun Biol· February 2021

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Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome.
Matthew C Sims, Louisa Mayer, Janine H Collins, Tadbir K Bariana, Karyn Megy, William J Astle

Blood· October 2020

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Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.
Ming-Huei Chen, Laura M Raffield, Abdou Mousas, Saori Sakaue, Jennifer E Huffman, William J Astle

Cell· September 2020

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The Polygenic and Monogenic Basis of Blood Traits and Diseases.
Dragana Vuckovic, Erik L Bao, Parsa Akbari, Caleb A Lareau, Abdou Mousas, William J Astle

Cell· September 2020

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Development and validation of a universal blood donor genotyping platform: a multinational prospective study.
Nicholas S Gleadall, Barbera Veldhuisen, Jeremy Gollub, Adam S Butterworth, John Ord, William J Astle

Blood Adv· August 2020

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Whole-genome sequencing of patients with rare diseases in a national health system.
Ernest Turro, William J Astle, Karyn Megy, Stefan Gräf, Daniel Greene

Nature· July 2020

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Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status.
Paul A Lyons, James E Peters, Federico Alberici, James Liley, Richard M R Coulson, William Astle

Nat Commun· November 2019

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Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.
Valentina Iotchkova, Jie Huang, John A Morris, Deepti Jain, Caterina Barbieri, William Astle

Nat Genet· December 2018

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Incidental neuroblastoma with bilateral retinoblastoma: what are the chances?
Kelsey Roelofs, Furqan Shaikh, William Astle, Brenda L Gallie, Sameh E Soliman

Ophthalmic Genet· June 2018

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Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies.
Angela M Wood, Stephen Kaptoge, Adam S Butterworth, Peter Willeit, Samantha Warnakula, William Astle

Lancet· April 2018

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Nbeal2 interacts with Dock7, Sec16a, and Vac14.
Louisa Mayer, Maria Jasztal, Mercedes Pardo, Salvadora Aguera de Haro, Janine Collins, William J Astle

Blood· March 2018

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Platelet function is modified by common sequence variation in megakaryocyte super enhancers.
Romina Petersen, John J Lambourne, Biola M Javierre, Luigi Grassi, Roman Kreuzhuber, William J Astle

Nat Commun· July 2017

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