Publications by authors named "William Farrell"

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Predictive design of crystallographic chiral separation.
Rokas Elijošius, Emma King-Smith, Felix A Faber, Louise Bernier, Simon Berritt, William P Farrell

Nat Commun· August 2025

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Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer.
Rebecca A Gallego, Sujin Cho-Schultz, Matthew Del Bel, Anne-Marie Dechert-Schmitt, Joyann S Donaldson, William Farrell

J Med Chem· December 2024

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At the intersection of sulfur redox chemistry, cellular signal transduction and proteostasis: A useful perspective from which to understand and treat neurodegeneration.
Kenneth Hensley, Alexis Danekas, William Farrell, Tiera Garcia, Wafa Mehboob

Free Radic Biol Med· January 2022

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Interactions of Both Pathogenic and Nonpathogenic CUG Clade Species with Macrophages Share a Conserved Transcriptional Landscape.
Andrew W Pountain, John R Collette, William M Farrell, Michael C Lorenz

mBio· December 2021

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High-Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates.
Helen A Clement, Michele Boghi, Rory M McDonald, Louise Bernier, Jotham W Coe, William Farrell

Angew Chem Int Ed Engl· December 2019

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Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies.
Pensee Wu, William E Farrell, Kim E Haworth, Richard D Emes, Mark O Kitchen

Epigenetics· December 2018

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First inter-laboratory study of a Supercritical Fluid Chromatography method for the determination of pharmaceutical impurities.
Amandine Dispas, Roland Marini, Vincent Desfontaine, Jean-Luc Veuthey, Dorina Kotoni, William P Farrell

J Pharm Biomed Anal· November 2018

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Applicability of supercritical fluid chromatography - mass spectrometry to metabolomics. I - Optimization of separation conditions for the simultaneous analysis of hydrophilic and lipophilic substances.
Vincent Desfontaine, Gioacchino Luca Losacco, Yoric Gagnebin, Julian Pezzatti, William P Farrell

J Chromatogr A· August 2018

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Kinetically guided radical-based synthesis of C(sp)-C(sp) linkages on DNA.
Jie Wang, Helena Lundberg, Shota Asai, Pedro Martín-Acosta, Jason S Chen, William Farrell

Proc Natl Acad Sci U S A· July 2018

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Epidrug-induced upregulation of functional somatostatin type 2 receptors in human pancreatic neuroendocrine tumor cells.
Marije J Veenstra, Peter M van Koetsveld, Fadime Dogan, William E Farrell, Richard A Feelders

Oncotarget· March 2018

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A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow.
Damith Perera, Joseph W Tucker, Shalini Brahmbhatt, Christopher J Helal, Ashley Chong, William Farrell

Science· January 2018

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Epigenome-wide association study of rheumatoid arthritis identifies differentially methylated loci in B cells.
Antonio Julià, Devin Absher, María López-Lasanta, Nuria Palau, Andrea Pluma, William E Farrell

Hum Mol Genet· July 2017

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DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis.
John R Glossop, Nicola B Nixon, Richard D Emes, Julius Sim, Jon C Packham, William E Farrell

Epigenomics· April 2017

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Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity.
Justin M Lopchuk, Kasper Fjelbye, Yu Kawamata, Lara R Malins, Chung-Mao Pan, William Farrell

J Am Chem Soc· March 2017

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The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization.
Vasileios A Stamelos, Natalie Fisher, Harnoor Bamrah, Carolyn Voisey, Joshua C Price, William E Farrell

PLoS One· August 2016

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DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS.
John R Glossop, Kim E Haworth, Richard D Emes, Nicola B Nixon, Jon C Packham, William E Farrell

Epigenomics· June 2016

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Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer.
Mark O Kitchen, Richard T Bryan, Kim E Haworth, Richard D Emes, Christopher Luscombe, William E Farrell

PLoS One· May 2016

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Near roadway air pollution across a spatially extensive road and cycling network.
William Farrell, Scott Weichenthal, Mark Goldberg, Marie-France Valois, Maryam Shekarrizfard

Environ Pollut· May 2016

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Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer.
Mark O Kitchen, Richard T Bryan, Richard D Emes, John R Glossop, Christopher Luscombe, William E Farrell

Epigenetics· March 2016

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Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes.
John R Glossop, Richard D Emes, Nicola B Nixon, Jon C Packham, Anthony A Fryer, William E Farrell

Epigenomics· February 2016

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Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells.
Mark O Kitchen, Kiren Yacqub-Usman, Richard D Emes, Alan Richardson, Richard N Clayton, William E Farrell

Pituitary· October 2015

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Methylation of the FGFR2 gene is associated with high birth weight centile in humans.
Kim E Haworth, William E Farrell, Richard D Emes, Khaled M K Ismail, William D Carroll

Epigenomics· July 2015

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Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation.
Giampaolo Trivellin, Adrian F Daly, Fabio R Faucz, Bo Yuan, Liliya Rostomyan, William E Farrell

N Engl J Med· December 2014

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Evaluation of stationary phases packed with superficially porous particles for the analysis of pharmaceutical compounds using supercritical fluid chromatography.
Alexandre Grand-Guillaume Perrenoud, William P Farrell, Christine M Aurigemma, Nicole C Aurigemma, Szabolcs Fekete

J Chromatogr A· September 2014

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Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations.
John R Glossop, Richard D Emes, Nicola B Nixon, Kim E Haworth, Jon C Packham, William E Farrell

Epigenetics· September 2014

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