Publications by authors named "William Fitch"

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Complex Metabolism of the Novel Neurosteroid, Ganaxolone, in Humans: A Unique Challenge for Metabolites in Safety Testing Assessment.
William L Fitch, Steven Smith, Michael Saporito, Gregory Busse, Mingbao Zhang

Drug Metab Dispos· June 2023

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Corrigendum to 'The evolution of the British Journal of Anaesthesia: the first 100 years' [Br J Anaesth 2023; 130: 3-7].
William Fitch, Graham Smith, Jennifer M Hunter, Charles S Reilly, Ravi P Mahajan

Br J Anaesth· April 2023

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The evolution of the British Journal of Anaesthesia: the first 100 years.
William Fitch, Graham Smith, Jennifer M Hunter, Charles S Reilly, Ravi P Mahajan

Br J Anaesth· January 2023

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Discovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy.
Robert K Leśniak, R Jeremy Nichols, Marcus Schonemann, Jing Zhao, Chandresh R Gajera, William L Fitch

Eur J Med Chem· February 2022

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Selection on vocal output affects laryngeal morphology in rats.
Raffaela Lesch, Thomas Schwaha, Andrea Orozco, Margaret Shilling, Susan Brunelli, William Tecumseh Fitch

J Anat· May 2021

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Using LC Retention Times in Organic Structure Determination: Drug Metabolite Identification.
William L Fitch, Cyrus Khojasteh, Ignacio Aliagas, Kevin Johnson

Drug Metab Lett· June 2019

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Tunable Enzymatic Synthesis of the Immunomodulator Lipid IV To Enable Structure-Activity Analysis.
Karthik Sankaranarayanan, Xirui X Antaris, Brad A Palanski, Abrahim El Gamal, Camilla M Kao, William L Fitch

J Am Chem Soc· June 2019

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In vitro and in vivo metabolite identification of a novel benzimidazole compound ZLN005 by liquid chromatography/tandem mass spectrometry.
Wenchao Sun, Khoa Dinh Nguyen, William L Fitch, Samuel D Banister, Hongxiang Tang

Rapid Commun Mass Spectrom· March 2018

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Small-Volume Injections: Evaluation of Volume Administration Deviation From Intended Injection Volumes.
Matthew K Muffly, Michael I Chen, Rebecca E Claure, David R Drover, Bradley Efron, William L Fitch

Anesth Analg· October 2017

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RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials.
Bryan Oronsky, Ramasamy Paulmurugan, Kira Foygel, Jan Scicinski, Susan J Knox, William L Fitch

Expert Opin Investig Drugs· January 2017

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Take the long way home: Behaviour of a neotropical frog, Allobates femoralis, in a detour task.
Alexandru Marian Munteanu, Iris Starnberger, Andrius Pašukonis, Thomas Bugnyar, Walter Hödl, William Tecumseh Fitch

Behav Processes· May 2016

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Novel Series of Dihydropyridinone P2X7 Receptor Antagonists.
Francisco Lopez-Tapia, Keith A M Walker, Christine Brotherton-Pleiss, Joanie Caroon, Dov Nitzan, William L Fitch

J Med Chem· November 2015

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Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study.
Tony Reid, Bryan Oronsky, Jan Scicinski, Curt L Scribner, Susan J Knox, William L Fitch

Lancet Oncol· September 2015

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Development of methods for the bioanalysis of RRx-001 and metabolites.
Jan Scicinski, Bryan Oronsky, Vance Cooper, Michael Taylor, Mike Alexander, William L Fitch

Bioanalysis· April 2014

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Liquid chromatography/mass spectrometry methods for measuring dipeptide abundance in non-small-cell lung cancer.
Manhong Wu, Yue Xu, William L Fitch, Ming Zheng, Robert E Merritt

Rapid Commun Mass Spectrom· September 2013

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Metabolomic-derived novel cyst fluid biomarkers for pancreatic cysts: glucose and kynurenine.
Walter G Park, Manhong Wu, Raffick Bowen, Ming Zheng, William L Fitch

Gastrointest Endosc· August 2013

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Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction.
Toshihiko Nishimura, Yajing Hu, Manhong Wu, Edward Pham, Hiroshi Suemizu, William L Fitch

J Pharmacol Exp Ther· February 2013

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A three-parameter model for classifying anurans into four genera based on advertisement calls.
Bruno Gingras, William Tecumseh Fitch

J Acoust Soc Am· January 2013

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Identification of drug targets by chemogenomic and metabolomic profiling in yeast.
Manhong Wu, Ming Zheng, Weiruo Zhang, Sundari Suresh, Ulrich Schlecht, William L Fitch

Pharmacogenet Genomics· December 2012

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Preclinical evaluation of the metabolism and disposition of RRx-001, a novel investigative anticancer agent.
Jan Scicinski, Bryan Oronsky, Michael Taylor, Gang Luo, Timothy Musick, William L Fitch

Drug Metab Dispos· September 2012

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Identification of metabolites in Withania sominfera fruits by liquid chromatography and high-resolution mass spectrometry.
Jayaprakasam Bolleddula, William Fitch, Shaiju K Vareed, Muraleedharan G Nair

Rapid Commun Mass Spectrom· June 2012

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Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses.
Guozhi Tang, Denis J Kertesz, Minmin Yang, Xianfeng Lin, Zhanguo Wang, William L Fitch

Bioorg Med Chem Lett· October 2010

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Application of modern drug metabolism structure determination tools and assays to the in vitro metabolism of imiloxan.
William L Fitch, Yuan Chen, Liling Liu, Axel Paehler, May Young

Drug Metab Lett· April 2010

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Revisiting the metabolism of ketoconazole using accurate mass.
William L Fitch, Thuy Tran, May Young, Liling Liu, Yuan Chen

Drug Metab Lett· August 2009

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Comparison of in vitro bioactivation of flutamide and its cyano analogue: evidence for reductive activation by human NADPH:cytochrome P450 reductase.
Bo Wen, Kevin J Coe, Peter Rademacher, William L Fitch, Mario Monshouwer

Chem Res Toxicol· December 2008

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