Publications by authors named "William J Netzer"

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Stretching the structural envelope of imatinib to reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP.
William J Netzer, Anjana Sinha, Mondana Ghias, Emily Chang, Katherina Gindinova

Front Chem· October 2024

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Development of Kinase Inactive PD173955 Analogues for Reducing Production of Aβ Peptides.
Anjana Sinha, Katherina Gindinova, Emily Mui, William J Netzer, Subhash C Sinha

ACS Med Chem Lett· October 2019

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Development of Gleevec Analogues for Reducing Production of β-Amyloid Peptides through Shifting β-Cleavage of Amyloid Precursor Proteins.
Weilin Sun, William J Netzer, Anjana Sinha, Katherina Gindinova, Emily Chang

J Med Chem· March 2019

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Nose-to-brain transport of imatinib mesylate: A pharmacokinetic evaluation.
Nobuko Hada, William Joseph Netzer, Fanny Belhassan, Lawrence Paul Wennogle, Sveinbjörn Gizurarson

Eur J Pharm Sci· May 2017

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Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage.
William J Netzer, Karima Bettayeb, Subhash C Sinha, Marc Flajolet, Paul Greengard

Proc Natl Acad Sci U S A· February 2017

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δ-COP modulates Aβ peptide formation via retrograde trafficking of APP.
Karima Bettayeb, Jerry C Chang, Wenjie Luo, Suvekshya Aryal, Dante Varotsis, William J Netzer

Proc Natl Acad Sci U S A· May 2016

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Dynamin 1 regulates amyloid generation through modulation of BACE-1.
Li Zhu, Meng Su, Louise Lucast, Lijuan Liu, William J Netzer

PLoS One· February 2013

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Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.
Gen He, Wenjie Luo, Peng Li, Christine Remmers, William J Netzer

Nature· September 2010

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Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model.
William J Netzer, Craig Powell, Yi Nong, Jacqueline Blundell, Lili Wong

PLoS One· June 2010

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A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation.
Yun-wu Zhang, Shijie Liu, Xue Zhang, Wu-Bo Li, Yaomin Chen, William J Netzer

Neuron· November 2009

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Beta-amyloid modulation of synaptic transmission and plasticity.
Deepa V Venkitaramani, Jeannie Chin, William J Netzer, Gunnar K Gouras, Sylvain Lesne

J Neurosci· October 2007

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Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.
Dongming Cai, Minghao Zhong, Runsheng Wang, William J Netzer, Dennis Shields

Proc Natl Acad Sci U S A· February 2006

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Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.
Dongming Cai, William J Netzer, Minghao Zhong, Yixin Lin, Guangwei Du

Proc Natl Acad Sci U S A· February 2006

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Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory.
Shi Jie Liu, Ai Hong Zhang, Hong Lian Li, Qun Wang, Heng Mei Deng, William J Netzer

J Neurochem· December 2003

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Gleevec inhibits beta-amyloid production but not Notch cleavage.
William J Netzer, Fei Dou, Dongming Cai, Darren Veach, Stephanie Jean

Proc Natl Acad Sci U S A· October 2003

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Chaperones increase association of tau protein with microtubules.
Fei Dou, William J Netzer, Kentaro Tanemura, Feng Li, F Ulrich Hartl

Proc Natl Acad Sci U S A· January 2003

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Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761.
Yuan Luo, Julie V Smith, Vijaykumar Paramasivam, Adam Burdick, Kenneth J Curry, William J Netzer

Proc Natl Acad Sci U S A· September 2002

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Does insulin dysfunction play a role in Alzheimer's disease?
Laura Gasparini, William J Netzer, Paul Greengard, Huaxi Xu

Trends Pharmacol Sci· June 2002

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