Publications by authors named "Witold Gladkowski"

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Novel Halolactones Derived from Vanillin: Design, Synthesis, Structural Characterization, and Evaluation of Antiproliferative and Hemolytic Activities.
Anna Dunal, Witold Gładkowski, Ewa Dejnaka, Joanna Sulecka-Zadka, Aleksandra Pawlak

Molecules· October 2025

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Biophysical and molecular interactions of enantiomeric piperonal-derived trans β-aryl-δ-iodo-γ-lactones with cancer cell membranes, protein and DNA: Implications for anticancer activity.
Aleksandra Włoch, Priti Sengupta, Natalia Szulc, Teresa Kral, Aleksandra Pawlak

Int J Biol Macromol· April 2025

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Novel Lipid-Based Carriers of Provitamin D: Synthesis and Spectroscopic Characterization of Acylglycerol Conjugated with 7-Dehydrocholesterol Residue and Its Glycerophospholipid Analogue.
Witold Gładkowski, Susanna Ortlieb, Natalia Niezgoda, Anna Chojnacka, Paulina Fortuna

Molecules· December 2024

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Conjugates of 1,3- and 1,2-Acylglycerols with Stigmasterol: Synthesis, NMR Characterization, and Impact on Lipid Bilayers.
Witold Gładkowski, Anna Chojnacka, Aleksandra Włoch, Hanna Pruchnik, Aleksandra Grudniewska

Chempluschem· May 2023

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Chalcone-Derived Lactones: Synthesis, Whole-Cell Biotransformation, and Evaluation of Their Antibacterial and Antifungal Activity.
Witold Gładkowski, Monika Siepka, Barbara Żarowska, Agata Białońska, Barbara Gawdzik

Molecules· April 2023

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Effect of Distigmasterol-Modified Acylglycerols on the Fluidity and Phase Transition of Lipid Model Membranes.
Hanna Pruchnik, Aleksandra Włoch, Witold Gładkowski, Aleksandra Grudniewska, Anna Chojnacka

Membranes (Basel)· October 2022

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Lipase-mediated Baeyer-Villiger oxidation of benzylcyclopentanones in ester solvents and deep eutectic solvents.
Marcelina Mazur, Tomasz Janeczko, Witold Gładkowski

Sci Rep· August 2022

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Acylglycerols of Myristic Acid as New Candidates for Effective Stigmasterol Delivery-Design, Synthesis, and the Influence on Physicochemical Properties of Liposomes.
Witold Gładkowski, Aleksandra Włoch, Hanna Pruchnik, Anna Chojnacka, Aleksandra Grudniewska

Molecules· May 2022

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Distigmasterol-Modified Acylglycerols as New Structured Lipids-Synthesis, Identification and Cytotoxicity.
Magdalena Rudzińska, Aleksandra Grudniewska, Anna Chojnacka, Witold Gładkowski, Gabriela Maciejewska

Molecules· November 2021

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Methoxy-Substituted γ-Oxa-ε-Lactones Derived from Flavanones-Comparison of Their Anti-Tumor Activity In Vitro.
Aleksandra Pawlak, Marta Henklewska, Beatriz Hernández-Suárez, Monika Siepka, Witold Gładkowski

Molecules· October 2021

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Antiproliferative, Antimicrobial and Antiviral Activity of β-Aryl-δ-iodo-γ-lactones, Their Effect on Cellular Oxidative Stress Markers and Biological Membranes.
Aleksandra Włoch, Dominika Stygar, Fouad Bahri, Barbara Bażanów, Piotr Kuropka

Biomolecules· November 2020

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Free and Immobilized Lecitase™ Ultra as the Biocatalyst in the Kinetic Resolution of ()-4-Arylbut-3-en-2-yl Esters.
Aleksandra Leśniarek, Anna Chojnacka, Radosław Drozd, Magdalena Szymańska, Witold Gładkowski

Molecules· February 2020

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Chemoenzymatic Synthesis of Enantiomeric, Bicyclic δ-Halo-γ-lactones with a Cyclohexane Ring, Their Biological Activity and Interaction with Biological Membranes.
Marcelina Mazur, Aleksandra Włoch, Fouad Bahri, Hanna Pruchnik, Aleksandra Pawlak

Biomolecules· January 2020

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Synthesis and Antimicrobial Activity of Methoxy- Substituted γ-Oxa-ε-lactones Derived from Flavanones.
Witold Gładkowski, Monika Siepka, Tomasz Janeczko, Edyta Kostrzewa-Susłow, Jarosław Popłoński

Molecules· November 2019

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Microbial Asymmetric Functionalization of β-Cyclocitral-Derived Tetramethyl-Substituted γ-Lactone.
Marcelina Mazur, Witold Gładkowski, Aleksandra Pawlak, Bożena Obmińska-Mrukowicz, Gabriela Maciejewska

Molecules· February 2019

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Preparation of Enantiomeric β-(2',5'-Dimethylphenyl)Bromolactones, Their Antiproliferative Activity and Effect on Biological Membranes.
Witold Gładkowski, Aleksandra Włoch, Aleksandra Pawlak, Angelika Sysak, Agata Białońska

Molecules· November 2018

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Microbial Hydrolysis of Racemic β-Aryl-γ-ethylidene-γ-lactones and Antifeedant Activity of the Products against Panzer.
Andrzej Skrobiszewski, Witold Gładkowski, Marcelina Mazur, Maryla Szczepanik, Gabriela Maciejewska

Molecules· June 2018

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Enantiomeric trans β-aryl-δ-iodo-γ-lactones derived from 2,5-dimethylbenzaldehyde induce apoptosis in canine lymphoma cell lines by downregulation of anti-apoptotic Bcl-2 family members Bcl-xL and Bcl-2.
Aleksandra Pawlak, Witold Gładkowski, Justyna Kutkowska, Marcelina Mazur, Bożena Obmińska-Mrukowicz

Bioorg Med Chem Lett· April 2018

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Regio- and enantioselective microbial hydroxylation and evaluation of cytotoxic activity of β-cyclocitral-derived halolactones.
Marcelina Mazur, Witold Gładkowski, Višnja Gaurina Srček, Kristina Radošević, Gabriela Maciejewska

PLoS One· October 2017

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Lipase-Catalyzed Transesterification of Egg-Yolk Phophatidylcholine with Concentrate of n-3 Polyunsaturated Fatty Acids from Cod Liver Oil.
Anna Chojnacka, Witold Gładkowski, Aleksandra Grudniewska

Molecules· October 2017

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Isoprenoid-phospholipid conjugates as potential therapeutic agents: Synthesis, characterization and antiproliferative studies.
Anna Gliszczyńska, Natalia Niezgoda, Witold Gładkowski, Marta Świtalska, Joanna Wietrzyk

PLoS One· August 2017

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Synthesis and Biological Evaluation of Novel Phosphatidylcholine Analogues Containing Monoterpene Acids as Potent Antiproliferative Agents.
Anna Gliszczyńska, Natalia Niezgoda, Witold Gładkowski, Marta Czarnecka, Marta Świtalska

PLoS One· July 2017

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Optically active stereoisomers of 5-(1-iodoethyl)-4-(4'-isopropylphenyl)dihydrofuran-2-one: The effect of the configuration of stereocenters on apoptosis induction in canine cancer cell lines.
Aleksandra Pawlak, Witold Gładkowski, Marcelina Mazur, Marta Henklewska, Bożena Obmińska-Mrukowicz

Chem Biol Interact· January 2017

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Chemoenzymatic Synthesis of trans-β-Aryl-δ-hydroxy-γ-lactones and Enzymatic Kinetic Resolution of Their Racemic Mixtures.
Andrzej Skrobiszewski, Witold Gładkowski, Gabriela Maciejewska, Czesław Wawrzeńczyk

Molecules· November 2016

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Dehalogenation Activity of Selected Fungi Toward δ-Iodo-γ-Lactone Derived from trans,trans-Farnesol.
Anna Gliszczyńska, Witold Gładkowski, Marta Świtalska, Joanna Wietrzyk, Antoni Szumny

Chem Biodivers· April 2016

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