Publications by authors named "Won Jin Ho"

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The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities.
Won Jin Ho, Elizabeth M Jaffee, Lei Zheng

Nat Rev Clin Oncol· September 2020

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A phase 2 trial of CXCR4 antagonism and PD1 inhibition in metastatic pancreatic adenocarcinoma reveals recruitment of T cells but also immunosuppressive macrophages.
Katherine M Bever, Sarah M Shin, Jennifer N Durham, Hanfei Qi, Alexei Hernandez, Won Jin Ho

Oncoimmunology· December 2025

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A therapeutic peptide vaccine for fibrolamellar hepatocellular carcinoma: a phase 1 trial.
Marina Baretti, Allison M Kirk, Brian H Ladle, Zeal Kamdar, Kayla J Bendinelli, Won Jin Ho, Nicholas A Clark, Chris Thoburn, Paul G Thomas, Mark Yarchoan

Nat Med· December 2025

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Correction: Nivolumab and Relatlimab for the Treatment of Patients with Unresectable or Metastatic Mismatch Repair-Proficient Colorectal Cancer.
Eric S Christenson, Won Jin Ho, Daniel Shu, Jennifer N Durham, Madelena Brancati, Ross Donehower, Franck Housseau

Clin Cancer Res· December 2025

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Neoadjuvant Immunotherapy Promotes the Formation of Mature Tertiary Lymphoid Structures in a Remodeled Pancreatic Tumor Microenvironment.
Dimitrios N Sidiropoulos, Sarah M Shin, Meredith Wetzel, Alexander A Girgis, Daniel Bergman, Mark Yarchoan, Won Jin Ho

Cancer Immunol Res· November 2025

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DNAJ-PKAc induces metabolic rewiring and enhanced glutamine flux in fibrolamellar HCC.
Zeal Kamdar, Ethan Neumann, Kathryn Howe, Donald Long, Waqar Arif, Paul G Thomas, Won Jin Ho, Mark Yarchoan

J Hepatol· November 2025

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Quantitative Calibration of a Spatial QSP Model Identifies Fibroblast Impact on HCC Immunotherapy.
Shuming Zhang, Hanwen Wang, Yeonju Cho, Wendy Wong, Mark Yarchoan, Won Jin Ho

bioRxiv· November 2025

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Immune Activation Signatures Associated with Fatigue in Cancer Patients Undergoing Immune Checkpoint Inhibitor Therapy.
Howard L Li, Soren Charmsaz, Mari Nakazawa, Stephanie L Alden, Madelena Brancati, Christopher J Thoburn, Jean Hoffman-Censits, Won Jin Ho, Mark Yarchoan

Cancer Res Commun· October 2025

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Neutrophils drive vascular occlusion, tumour necrosis and metastasis.
Jose M Adrover, Xiao Han, Lijuan Sun, Takeo Fujii, Nicole Sivetz, Won Jin Ho

Nature· September 2025

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Nivolumab and Relatlimab for the Treatment of Patients with Unresectable or Metastatic Mismatch Repair-Proficient Colorectal Cancer.
Eric S Christenson, Won Jin Ho, Daniel Shu, Jennifer N Durham, Madelena Brancati, Ross Donehower, Franck Housseau

Clin Cancer Res· August 2025

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Spatial proteomics and transcriptomics reveal early immune cell organization in pancreatic intraepithelial neoplasia.
Melissa R Lyman, Jacob T Mitchell, Sidharth Raghavan, Luciane T Kagohara, Amanda L Huff, Yun Zhou Liu, Elizabeth D Thompson, Won Jin Ho

JCI Insight· August 2025

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Ablating UNG activity in a mouse model inhibits colorectal cancer growth by increasing tumor immunogenicity.
Eric S Christenson, Brandon E Smith, Thanh J Nguyen, Alens Valentin, Soren Charmsaz, Won Jin Ho

JCI Insight· August 2025

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Anti-CTLA4 Therapy Leads to Early Expansion of a Peripheral Th17 Population and Induction of Th1 Cytokines.
Mari Nakazawa, Soren Charmsaz, Elsa Hallab, Mike Fang, Chester Kao, Howard L Li, Christopher J Thoburn, Jean Hoffman-Censits, Won Jin Ho, Mark Yarchoan

Cancer Immunol Res· June 2025

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PIVOT: an open-source tool for multi-omic spatial data registration.
André Forjaz, Valentina Matos Romero, Ian Reucroft, Margaret Eminizer, Donald Kramer, Won Jin Ho

bioRxiv· June 2025

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Modeling cellular influence delineates functionally relevant cellular neighborhoods in primary and metastatic pancreatic ductal adenocarcinoma.
Yeonju Cho, Jae W Lee, Sarah M Shin, Alexei G Hernandez, Xuan Yuan, Jody E Hooper, Won Jin Ho

bioRxiv· June 2025

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Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially control regulatory T cell phenotype and function via CXCL9 and CCL22.
Saumya Y Maru, Meredith Wetzel, Jacob T Mitchell, Nicole E Gross, Lalitya Andaloori, Kathryn Howe, Won Jin Ho

bioRxiv· April 2025

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Age-related divergence of circulating immune responses in patients with solid tumors treated with immune checkpoint inhibitors.
Chester Kao, Soren Charmsaz, Hua-Ling Tsai, Khaled Aziz, Daniel H Shu, Jeannie Hoffman-Censits, Howard L Li, Christopher Thoburn, Won Jin Ho, Mark Yarchoan

Nat Commun· April 2025

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Immune-related events in individuals with solid tumors on immunotherapy associate with Th17 and Th2 signatures.
Chester J Kao, Soren Charmsaz, Stephanie L Alden, Madelena Brancati, Howard L Li, Kathryn Howe, Chris Thoburn, Jean Hoffman-Censits, Won Jin Ho, Mark Yarchoan

J Clin Invest· March 2025

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Targeted dual biologic therapy for erythroderma of unknown etiology guided by high-parameter peripheral blood immunophenotyping.
Hannah L Cornman, Martin P Alphonse, Arbor Dykema, Alexander L Kollhoff, Kevin K Lee, Thomas Pritchard, Won Jin Ho

Sci Rep· January 2025

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CD137 agonism enhances anti-PD1 induced activation of expanded CD8 T cell clones in a neoadjuvant pancreatic cancer clinical trial.
Janelle M Montagne, Jacob T Mitchell, Joseph A Tandurella, Eric S Christenson, Ludmila V Danilova, Won Jin Ho, Wenpin Hou

iScience· January 2025

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Cancer associated fibroblasts drive epithelial to mesenchymal transition and classical to basal change in pancreatic ductal adenocarcinoma cells with loss of IL-8 expression.
Samantha Guinn, Brayan Perez, Joseph A Tandurella, Mili Ramani, Jae W Lee, Nicholas Sun, Yeonju Cho, Won Jin Ho

bioRxiv· January 2025

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Pan-tumor analysis to investigate the obesity paradox in immune checkpoint blockade.
Stephanie L Alden, Soren Charmsaz, Howard L Li, Hua-Ling Tsai, Ludmila Danilova, Kathryn Howe, Chris Thoburn, Jean Hoffman-Censits, Won Jin Ho, Mark Yarchoan

J Immunother Cancer· January 2025

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Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma.
Daniel H Shu, Won Jin Ho, Luciane T Kagohara, Alexander Girgis, Sarah M Shin, Kathryn Howe, Mark Yarchoan

Nat Immunol· November 2024

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Entinostat in combination with nivolumab in metastatic pancreatic ductal adenocarcinoma: a phase 2 clinical trial.
Marina Baretti, Ludmila Danilova, Jennifer N Durham, Courtney B Betts, Leslie Cope, Won Jin Ho, Chris Thoburn, Mark Yarchoan

Nat Commun· November 2024

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Durable Response to Combined Nivolumab, Lenvatinib, and Radiation Therapy Against Oligometastatic Hepatocellular Carcinoma.
Sewoon Chun, Erin M Coyne, Jeffrey Meyer, Won Jin Ho

Cureus· November 2024

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Immune-related events in individuals with solid tumors on immunotherapy associate with Th17 and Th2 signatures.
Chester J Kao, Soren Charmsaz, Stephanie L Alden, Madelena Brancati, Howard L Li, Kathryn Howe, Chris Thoburn, Jean Hoffman-Censits, Won Jin Ho, Mark Yarchoan

J Clin Invest· August 2024

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