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Nat Rev Clin Oncol September 2020 PMID 32398706

The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities.

Won Jin Ho, Elizabeth M Jaffee, Lei Zheng

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Mentions

48
Peak: 33 in May 2020
across 4 sources since May 2020

Extended reach

100,765
potential audience

Total likes

96

Video views

45

Mentions per month

May 2020 – Jul 2025

Where it's discussed

  • X / Twitter40 posts
  • YouTube3 videos
  • Facebook3 posts
  • News2 articles

AI synopsis

What people are saying

The discussions highlight the significance of the article by noting its focus on complex strategies such as combined therapies and biologically targeted approaches, exemplified by phrases like 'clinical challenges and opportunities' and references to multiomics and immunotherapy. The tone and word choices emphasize the review's role in shaping future research directions, indicating a recognition of its potential impact within the scientific community.

AgreementModerate agreement

Most discussions acknowledge the importance and novelty of the review, with some supporting the idea that understanding the TME is crucial for advancing treatments.

InterestHigh interest

Posts show high curiosity, referencing cutting-edge therapies like multiomics and immunotherapy, indicating strong engagement with the subject matter.

EngagementModerate engagement

The comments reflect superficial mentions of the topic, with some referencing conferences and reviews, suggesting moderate but not deep analysis.

ImpactModerate impact

There is an overall sense that this review could influence ongoing research and clinical practices, though the tone remains professional rather than urgent.

Abstract in brief

  • Pancreatic cancer, especially metastatic pancreatic ductal adenocarcinoma (PDAC), remains highly deadly despite intensive chemotherapy, partly because of its complex tumor microenvironment (TME).
  • Efforts to target the TME—such as breaking down the dense stroma or blocking immunosuppressive pathways—have largely been unsuccessful, revealing that the TME is more intricate than initially thought.
  • Current research is exploring advanced, multi-pronged therapies that aim to modify the TME in a more sophisticated way, including combined treatment strategies and biologically targeted approaches, to improve patient outcomes.]
Read the full abstract

Top posts

Most liked on X and Bluesky
NatureRevClinOncol
@NatRevClinOncol · X

New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities' https://t.co/BMTPwFyjO3 #PancSM #camicroenv https://t.co/PLJm7Yeisi

May 13, 2020 · 67 likes · 31 shares · 41,538 followers View post →
Jun Gong
@jgong15 · X

Highlighting seminal work by our #KOL speakers -> 4th Annual @CedarsSinai #GI Tumor Conference (3/18/23): Dr. Lei Zheng @hopkinskimmel TME in #PDAC https://t.co/G7fXKKZ3kP & multiomics #PD-1 #IO in #PDAC https://t.co/csxUQEb5Wr @CSCancerCare Register at: https://t.co/7s8rEqfsBw https://t.co/AegcVWLkJV

Mar 1, 2023 · 9 likes · 4 shares · 1,650 followers View post →
J Controlled Release
@JCRnEDITORS · X

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities. | Nature Reviews Clinical Oncology | https://t.co/pNrVs3w6U6 https://t.co/BxjAj7qS51

May 13, 2020 · 7 likes · 3 shares · 7,786 followers View post →
Ricardo Carvalho
@rcarvalhoonco · X

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities | Nature Reviews Clinical Oncology https://t.co/BbIX7YUtm1

Jun 17, 2020 · 5 likes · 2,266 followers View post →
Garbiñe Lizeaga
@GarbineLizeaga · X

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities https://t.co/RzoDDFx5BU

May 12, 2020 · 3 likes · 1 share · 1,211 followers View post →
GEDEFO
@gedefo_sefh · X

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities #pancreaticcancer https://t.co/dG3cI302Pe

May 13, 2020 · 2 likes · 5,431 followers View post →

All mentions

Dr. Andrew Hendifar
@DrHendifar · X

RT @jgong15: Highlighting seminal work by our #KOL speakers -> 4th Annual @CedarsSinai #GI Tumor Conference (3/18/23): Dr. Lei Zheng @hopki…

Mar 2, 2023 · 4 shares · 901 followers View post →
Richard Ken Suzuki, PhD
@RichardKenSuzu1 · X

RT @jgong15: Highlighting seminal work by our #KOL speakers -> 4th Annual @CedarsSinai #GI Tumor Conference (3/18/23): Dr. Lei Zheng @hopki…

Mar 1, 2023 · 4 shares · 240 followers View post →
Dan Theodorescu
@Dan_Theodorescu · X

RT @jgong15: Highlighting seminal work by our #KOL speakers -> 4th Annual @CedarsSinai #GI Tumor Conference (3/18/23): Dr. Lei Zheng @hopki…

Mar 1, 2023 · 4 shares · 1,093 followers View post →
Cancer at Cedars-Sinai
@CSCancerCenter · X

RT @jgong15: Highlighting seminal work by our #KOL speakers -> 4th Annual @CedarsSinai #GI Tumor Conference (3/18/23): Dr. Lei Zheng @hopki…

Mar 1, 2023 · 4 shares · 1,686 followers View post →
Jun Gong
@jgong15 · X

Highlighting seminal work by our #KOL speakers -> 4th Annual @CedarsSinai #GI Tumor Conference (3/18/23): Dr. Lei Zheng @hopkinskimmel TME in #PDAC https://t.co/G7fXKKZ3kP & multiomics #PD-1 #IO in #PDAC https://t.co/csxUQEb5Wr @CSCancerCare Register at: https://t.co/7s8rEqfsBw https://t.co/AegcVWLkJV

Mar 1, 2023 · 9 likes · 4 shares · 1,650 followers View post →
pulepuboboding
@pulepuboboding · X

The Tumour Microenvironment in Pancreatic Cancer - Clinical Challenges and Opportunities https://t.co/FaNyIf3Zzg

Jun 23, 2020 · 932 followers View post →
Ricardo Carvalho
@rcarvalhoonco · X

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities | Nature Reviews Clinical Oncology https://t.co/BbIX7YUtm1

Jun 17, 2020 · 5 likes · 2,266 followers View post →
Jon Humphries
@JDHL18 · X

The Tumour Microenvironment in Pancreatic Cancer - Clinical Challenges and Opportunities https://t.co/d9eEt4tqmJ

May 18, 2020 · 1 like · 2,505 followers View post →
Dimitri Sidiropoulos
@DNSidiropoulos · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 17, 2020 · 31 shares · 595 followers View post →
James Leatherman
@jleathe3 · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 16, 2020 · 31 shares · 144 followers View post →
S. Chen
@Macro_Tregs · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 16, 2020 · 31 shares · 39 followers View post →
Cancer at Nature Portfolio
@NatResCancer · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 14, 2020 · 31 shares · 6,062 followers View post →
Alberto del Castillo
@Dr_AlCastillo · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 14, 2020 · 31 shares · 152 followers View post →
Siwen Hu-Lieskovan
@SiwenONC · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 14, 2020 · 31 shares · 462 followers View post →
Mark Yarchoan
@MarkYarchoan · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 14, 2020 · 31 shares · 1,905 followers View post →
Victoria Hendry
@HendryVictoria · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 1,318 followers View post →
ICKCHAN KWON
@DoubleParr · X

RT @JCRnEDITORS: The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities. | Nature Reviews Clinical Oncolo…

May 13, 2020 · 3 shares · 1,085 followers View post →
Markus P. Vallaster
@Stigmehaimatine · X

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities | Nature Reviews Clinical Oncology https://t.co/5KmVXJHr1K

May 13, 2020 · 77 followers View post →
Kais Kugasia
@KaisKugasia · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 29 followers View post →
Hashem O Alsaab هاشم الصعب
@hashemalsaab · X

RT @JCRnEDITORS: The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities. | Nature Reviews Clinical Oncolo…

May 13, 2020 · 3 shares · 4,450 followers View post →
J Controlled Release
@JCRnEDITORS · X

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities. | Nature Reviews Clinical Oncology | https://t.co/pNrVs3w6U6 https://t.co/BxjAj7qS51

May 13, 2020 · 7 likes · 3 shares · 7,786 followers View post →
secret-itn
@ItnSecret · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 98 followers View post →
Monica-Amit Mishra
@PancanMonica · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 779 followers View post →
CB
@cebentrena · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 382 followers View post →
Dr. Sawsan Youssef, M.Sc. Ph.D.
@DRSY2000 · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 562 followers View post →
Olivier Elemento
@ElementoLab · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 6,251 followers View post →
Rikejoy Zhang
@77JoyZhang · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 34 followers View post →
GEDEFO
@gedefo_sefh · X

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities #pancreaticcancer https://t.co/dG3cI302Pe

May 13, 2020 · 2 likes · 5,431 followers View post →
Kala Nambiar, PhD MSCE
@dr_kalanambiar · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 414 followers View post →
lbgbox
@lbgbox · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 51 followers View post →
Venkat Addala, PhD
@TheNeoantigen · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 620 followers View post →
Ari E. Marciscano, MD
@AE_MarciscanoMD · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 1,182 followers View post →
Anil K Thotakura
@anil143India · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 147 followers View post →
deniztural
@drdeniztural · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 1,917 followers View post →
Cancer Research KI
@CancerResKI · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 417 followers View post →
Joan Climent
@clibajo · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 109 followers View post →
Rafael Correa Cano MD, MSc.
@Rf_Correa · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 1,008 followers View post →
la lumière de ma vie
@scientistmike35 · X

RT @NatRevClinOncol: New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic can…

May 13, 2020 · 31 shares · 1,521 followers View post →
NatureRevClinOncol
@NatRevClinOncol · X

New Review by Won Jin Ho, Elizabeth Jaffee & Lei Zheng now live online: 'The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities' https://t.co/BMTPwFyjO3 #PancSM #camicroenv https://t.co/PLJm7Yeisi

May 13, 2020 · 67 likes · 31 shares · 41,538 followers View post →
Garbiñe Lizeaga
@GarbineLizeaga · X

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities https://t.co/RzoDDFx5BU

May 12, 2020 · 3 likes · 1 share · 1,211 followers View post →