Publications by authors named "Xavier Florence"

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Research Advancements on Fluorinated and Non-Fluorinated 4- Phenyl(thio)ureido-Substituted 2,2-Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants.
Bernard Pirotte, Xavier Florence, Eric Goffin, Fabienne Leleux, Philippe Lebrun

Med Chem· June 2022

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2,2-Dimethyl-3,4-dihydro-2-1,4-benzoxazines as isosteres of 2,2-dimethylchromans acting as inhibitors of insulin release and vascular smooth muscle relaxants.
Bernard Pirotte, Xavier Florence, Eric Goffin, Philippe Lebrun

Medchemcomm· March 2019

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Deciphering Structure-Activity Relationships in a Series of 2,2-Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants.
Bernard Pirotte, Xavier Florence, Eric Goffin, Philippe Lebrun

ChemMedChem· November 2017

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4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion.
Bernard Pirotte, Xavier Florence, Eric Goffin, Marlen Borges Medeiros, Pascal de Tullio

Eur J Med Chem· October 2016

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Design and synthesis of new potassium channel activators derived from the ring opening of diazoxide: study of their vasodilatory effect, stimulation of elastin synthesis and inhibitory effect on insulin release.
Nafila Bouider, Wassim Fhayli, Zeinab Ghandour, Marjorie Boyer, Kamel Harrouche, Xavier Florence

Bioorg Med Chem· April 2015

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Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: from potassium channel openers to calcium entry blockers?
Xavier Florence, Vincent Desvaux, Eric Goffin, Pascal de Tullio, Bernard Pirotte

Eur J Med Chem· June 2014

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1,4,2-Benzo/pyridodithiazine 1,1-dioxides structurally related to the ATP-sensitive potassium channel openers 1,2,4-Benzo/pyridothiadiazine 1,1-dioxides exert a myorelaxant activity linked to a distinct mechanism of action.
Bernard Pirotte, Pascal de Tullio, Xavier Florence, Eric Goffin, Fabian Somers

J Med Chem· April 2013

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Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process.
Xavier Florence, Sébastien Dilly, Pascal de Tullio, Bernard Pirotte, Philippe Lebrun

Bioorg Med Chem· July 2011

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Development and validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of a synthetic intermediate of new 3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans using a single-isomer anionic cyclodextrin derivative and an ionic liquid.
Anne Rousseau, Xavier Florence, Bernard Pirotte, Anne Varenne, Pierre Gareil

J Chromatogr A· December 2010

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Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.
Bernard Pirotte, Pascal de Tullio, Quynh-Anh Nguyen, Fabian Somers, Pierre Fraikin, Xavier Florence

J Med Chem· January 2010

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New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as K(ATP) channel openers: modulation of the 4-position.
Xavier Florence, Sophie Sebille, Pascal de Tullio, Philippe Lebrun, Bernard Pirotte

Bioorg Med Chem· November 2009

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Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.
Smail Khelili, Xavier Florence, Mourad Bouhadja, Samia Abdelaziz, Nadia Mechouch

Bioorg Med Chem· June 2008

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New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers.
Sophie Sebille, Pascal de Tullio, Xavier Florence, Bénédicte Becker, Marie-Hélène Antoine

Bioorg Med Chem· May 2008

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Design, synthesis, and pharmacological evaluation of R/S-3,4-dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: toward tissue-selective pancreatic beta-cell KATP channel openers structurally related to (+/-)-cromakalim.
Sophie Sebille, David Gall, Pascal de Tullio, Xavier Florence, Philippe Lebrun

J Med Chem· July 2006

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