Publications by authors named "Xavier Legras"

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CRISPR/Cas9 gene therapy increases the risk of tumorigenesis in the mouse model of hereditary tyrosinemia type I.
Tong Chen, Mercedes Barzi, Nika Furey, Hyunjae R Kim, Francis P Pankowicz, Xavier Legras

JHEP Rep· April 2025

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A human liver chimeric mouse model for non-alcoholic fatty liver disease.
Beatrice Bissig-Choisat, Michele Alves-Bezerra, Barry Zorman, Scott A Ochsner, Mercedes Barzi, Xavier Legras

JHEP Rep· June 2021

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A hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome.
Robert L Kruse, Mercedes Barzi, Xavier Legras, Francis P Pankowicz, Nika Furey

JHEP Rep· April 2021

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Cre/LoxP-HBV plasmids generating recombinant covalently closed circular DNA genome upon transfection.
Robert L Kruse, Xavier Legras, Mercedes Barzi

Virus Res· January 2021

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Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing.
Francis P Pankowicz, Mercedes Barzi, Kang Ho Kim, Xavier Legras, Celeste Santos Martins

Gastroenterology· December 2018

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HBsAg-redirected T cells exhibit antiviral activity in HBV-infected human liver chimeric mice.
Robert L Kruse, Thomas Shum, Haruko Tashiro, Mercedes Barzi, Zhongzhen Yi, Xavier Legras

Cytotherapy· May 2018

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In Situ Liver Expression of HBsAg/CD3-Bispecific Antibodies for HBV Immunotherapy.
Robert L Kruse, Thomas Shum, Xavier Legras, Mercedes Barzi, Frank P Pankowicz

Mol Ther Methods Clin Dev· December 2017

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Erratum: A novel humanized mouse lacking murine p450 oxidoreductase for studying human drug metabolism.
Mercedes Barzi, Francis P Pankowicz, Barry Zorman, Xing Liu, Xavier Legras

Nat Commun· October 2017

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Differentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells.
Aaron J Velasquez-Mao, Christopher J M Tsao, Madeline N Monroe, Xavier Legras, Beatrice Bissig-Choisat

PLoS One· September 2017

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A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism.
Mercedes Barzi, Francis P Pankowicz, Barry Zorman, Xing Liu, Xavier Legras

Nat Commun· June 2017

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Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer.
Beatrice Bissig-Choisat, Claudia Kettlun-Leyton, Xavier D Legras, Barry Zorman, Mercedes Barzi

J Hepatol· August 2016

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Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia.
Francis P Pankowicz, Mercedes Barzi, Xavier Legras, Leroy Hubert, Tian Mi

Nat Commun· August 2016

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Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model.
Beatrice Bissig-Choisat, Lili Wang, Xavier Legras, Pradip K Saha, Leon Chen

Nat Commun· June 2015

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Identification of prostate-specific G-protein coupled receptor as a tumor antigen recognized by CD8(+) T cells for cancer immunotherapy.
Satoko Matsueda, Mingjun Wang, Jinsheng Weng, Ying Li, Bingnan Yin, Xavier Legras

PLoS One· February 2013

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NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.
Jun Cui, Liang Zhu, Xiaojun Xia, Helen Y Wang, Xavier Legras

Cell· April 2010

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A type-1 metacaspase from Acanthamoeba castellanii.
Wendy C Trzyna, Xavier D Legras, John S Cordingley

Microbiol Res· September 2008

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